Patrícia Severino

ORCID: 0000-0001-6527-6612
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About
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Research Areas
  • Advancements in Transdermal Drug Delivery
  • Essential Oils and Antimicrobial Activity
  • Advanced Drug Delivery Systems
  • Bee Products Chemical Analysis
  • biodegradable polymer synthesis and properties
  • Nanoparticle-Based Drug Delivery
  • Drug Solubulity and Delivery Systems
  • Nanoparticles: synthesis and applications
  • Electrospun Nanofibers in Biomedical Applications
  • Lipid Membrane Structure and Behavior
  • Graphene and Nanomaterials Applications
  • Wound Healing and Treatments
  • Nanocomposite Films for Food Packaging
  • Phytochemistry Medicinal Plant Applications
  • Research on Leishmaniasis Studies
  • Bone Tissue Engineering Materials
  • Hydrogels: synthesis, properties, applications
  • Insect Pest Control Strategies
  • RNA Interference and Gene Delivery
  • Agricultural and Food Sciences
  • Skin Protection and Aging
  • Tissue Engineering and Regenerative Medicine
  • Phytochemicals and Antioxidant Activities
  • Analytical Chemistry and Chromatography
  • Insect and Pesticide Research

Universidade Tiradentes
2016-2025

Instituto de Tecnologia e Pesquisa
2015-2024

Nanomed (Brazil)
2016-2024

Universidade Federal do Rio de Janeiro
2024

Instituto Tecnológico de Santo Domingo
2024

MCPHS University
2023-2024

Biotech (Brazil)
2020-2023

Brigham and Women's Hospital
2020-2022

Harvard University
2020-2022

Universidad de Granada
2022

Lipids and lipid nanoparticles are extensively employed as oral-delivery systems for drugs other active ingredients. These have been exploited many features in the field of pharmaceutical technology. usually enhance drug absorption gastrointestinal tract (GIT), when formulated nanoparticles, these molecules improve mucosal adhesion due to small particle size increasing their GIT residence time. In addition, may also protect loaded from chemical enzymatic degradation gradually release matrix...

10.1155/2012/750891 article EN cc-by Journal of Drug Delivery 2011-11-24

Polymer hydrogels have been suggested as dressing materials for the treatment of cutaneous wounds and tissue revitalization. In this work, we report development a hydrogel composed natural polymers (sodium alginate gelatin) silver nanoparticles (AgNPs) with recognized antimicrobial activity healing lesions. For hydrogel, different ratios sodium gelatin tested, while concentrations AgNO3 precursor (1.0, 2.0, 4.0 mM) were assayed production AgNPs. The obtained AgNPs exhibited characteristic...

10.3390/nano10020390 article EN cc-by Nanomaterials 2020-02-23

This analysis explores the principal regulatory concerns linked to nanomedicines and gene vaccines, including complexities involved perspectives on how navigate them. In realm of nanomedicines, ensuring safety nanomaterials is paramount due their unique characteristics potential interactions with biological systems. Regulatory bodies are actively formulating guidelines standards assess risks associated nanomedicine products, emphasizing need for standardized characterization techniques...

10.1016/j.actbio.2024.04.010 article EN cc-by Acta Biomaterialia 2024-04-10

Cosmetics composed of synthetic and/or semi-synthetic polymers, associated or not with natural exhibit a dashing design, thermal and chemo-sensitive properties. Cosmetic polymers are also used for the preparation nanoparticles delivery of, e.g., fragrances, purpose to modify their release profile reducing risk evaporation. Besides, other cosmetically active nutrients, dermal permeation enhancers, have been loaded into improve bioactivities on skin. The use in cosmetic formulations is...

10.3390/cosmetics7040075 article EN cc-by Cosmetics 2020-09-25

Essential oils are odorant liquid oily products consisting of a complex mixture volatile compounds obtained from plant raw material. They have been increasingly proven to act as potential natural agents in the treatment several human conditions, including diabetes mellitus (DM). DM is metabolic disorder characterized by chronic hyperglycemia closely related carbohydrate, protein and fat metabolism disturbances. In order explore novel approaches for management our group proposes encapsulation...

10.3390/molecules25030685 article EN cc-by Molecules 2020-02-06

In this work, we developed a solid lipid nanoparticle (SLN) formulation with (+)-limonene 1,2-epoxide and glycerol monostearate (Lim-SLNs), stabilized Poloxamer® 188 in aqueous dispersion to modify the release profile of loaded monoterpene derivative. We also evaluated role SLNs peroxidation cytotoxicity spontaneously transformed aneuploid immortal keratinocyte cell line from adult human skin (the HaCaT line). For viability assay, colorimetric...

10.3390/ijms21041449 article EN International Journal of Molecular Sciences 2020-02-20

Medicinal plants, many of which are wild, have recently been under the spotlight worldwide due to growing requests for natural and sustainable eco-compatible remedies pathological conditions with beneficial health effects that able support/supplement a daily diet or support and/or replace conventional pharmacological therapy. The main these products are: safety, minimum adverse unwanted effects, better efficacy, greater bioavailability, lower cost when compared synthetic medications...

10.3390/f11050564 article EN Forests 2020-05-18

Chitosan films are commonly used for wound dressing, provided that this polymer has healing, mucoadhesiveness and antimicrobial properties. These properties can be further reinforced by the combination of chitosan with polysaccharides glycoproteins present in aloe vera, together copaiba oleoresin's pharmacological activity attributed to sesquiterpenes. In work, we developed containing either oil or both, casting technique, evaluated their microbial permeation, activity, cytotoxicity, vivo...

10.1016/j.ijpharm.2023.122648 article EN cc-by International Journal of Pharmaceutics 2023-01-26
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