A5011327984- Essential Oils and Antimicrobial Activity
- Phytochemistry and Biological Activities
- Bee Products Chemical Analysis
- Natural product bioactivities and synthesis
- Piperaceae Chemical and Biological Studies
- Medicinal Plant Extracts Effects
- Phytochemistry Medicinal Plant Applications
- Advancements in Transdermal Drug Delivery
- Insect and Pesticide Research
- Pharmacological Effects of Natural Compounds
- Research on Leishmaniasis Studies
- Insect Pest Control Strategies
- Parasites and Host Interactions
- Helminth infection and control
- Medicinal Plants and Neuroprotection
- Wound Healing and Treatments
- Polysaccharides Composition and Applications
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Electrospun Nanofibers in Biomedical Applications
- Carbon Nanotubes in Composites
- Phytochemicals and Medicinal Plants
- Parasite Biology and Host Interactions
- Olfactory and Sensory Function Studies
- Antimicrobial agents and applications
Universidade Federal de Sergipe
2014-2024
Nanomed (Brazil)
2018-2023
Instituto de Tecnologia e Pesquisa
2018-2022
Universidade Tiradentes
2018-2020
Universidade de Sorocaba
2020
Polymer hydrogels have been suggested as dressing materials for the treatment of cutaneous wounds and tissue revitalization. In this work, we report development a hydrogel composed natural polymers (sodium alginate gelatin) silver nanoparticles (AgNPs) with recognized antimicrobial activity healing lesions. For hydrogel, different ratios sodium gelatin tested, while concentrations AgNO3 precursor (1.0, 2.0, 4.0 mM) were assayed production AgNPs. The obtained AgNPs exhibited characteristic...
Propolis is known for its biological properties and preparations have been continuously investigated in an attempt to solve the problem of their standardization, issue that limits use propolis food pharmaceutical industries. The aim this study was evaluate vitro antioxidant, antimicrobial, antiparasitic, cytotoxic effects extracts red, green, brown from different regions Brazil, obtained by ethanolic supercritical extraction methods. We found both these methods showed concentration-dependent...
Propolis is a complex mixture of resinous and balsamic material collected from the exudates plants, shoots, leaves by bees. This study evaluated red propolis extracts obtained conventional (ethanolic) extraction ultrasound-assisted six samples different regions northeastern Brazil. The total phenolic compounds flavonoids, in vitro antioxidant activity, concentration formononetin kaempferol cytotoxicity against four human tumor cell lines were determined for all twelve extracts. Significant...
In this work, we developed a solid lipid nanoparticle (SLN) formulation with (+)-limonene 1,2-epoxide and glycerol monostearate (Lim-SLNs), stabilized Poloxamer® 188 in aqueous dispersion to modify the release profile of loaded monoterpene derivative. We also evaluated role SLNs peroxidation cytotoxicity spontaneously transformed aneuploid immortal keratinocyte cell line from adult human skin (the HaCaT line). For viability assay, colorimetric...
This review is aimed at presenting relevant information on the therapeutic potential of essential oil sesquiterpenes with anti-inflammatory activity. The data reviewed provide a basis for seeking new drugs from natural products that do not exhibit undesirable side effects often displayed by drugs. In this experimental models, possible mechanisms action, and chemical structures 12 are presented.
Mucoadhesive membranes were proposed in this study as drug delivery system for betamethasone-17-valerate (BMV) the treatment of recurrent aphthous stomatitis (RAS). The obtained by using polymers chitosan (CHI) both presence and absence polyvinilpyrrolidone (PVP), following solvent evaporation method. PVP causes significant modifications its thermal properties. Changes events at 114 193 °C (related to BMV melting point), losses mass (39.38 30.68% CH:PVP CH:PVP-B, respectively), suggests...
Brazilian red propolis has been proposed as a new source of compounds with cytotoxic activity. Red is resinous material vegetal origin, synthesized from the bees Appis mellifera family, recognized biological properties. To obtain actives low polarity and high profile propolis, in this work, we solvent accelerated extraction method. A complete 23 factorial design was carried out to evaluate influence independent variables or factors (e.g., temperature, number cycles, time) on dependent...
Medicinal plants have been commonly associated with chemotherapeutic treatments, as an approach to reduce the toxicological risks of classical anticancer drugs. The objective this study was evaluate effects combining antineoplastic drug 5-fluorouracil (5-FU) Matricaria recutita flowers extract (MRFE) treat mice transplanted sarcoma 180. Tumor inhibition, body and visceral mass variation, biochemical, hematological, histopathological parameters were evaluated. isolated 5-FU, 5-FU+MRFE 100...
Solid lipid nanoparticles (SLNs) can be produced by various methods, but most of them are difficult to scale up. Supercritical fluid (SCF) is an important tool produce micro/nanoparticles with a narrow size distribution and high encapsulation efficiency. The aim this work was cetyl palmitate SLNs using SCF loaded praziquantel (PZQ) as insoluble model drug. mean particle (nm), polydispersity index (PdI), zeta potential, efficiency (EE) were determined on the freshly prepared samples, which...
We have developed a new cationic solid lipid nanoparticle (SLN) formulation, composed of Compritol ATO 888, poloxamer 188 and cetyltrimethylammonium bromide (CTAB), to load perillaldehyde 1,2-epoxide, surface-tailored with monoclonal antibody for site-specific targeting human epithelial growth receptor 2 (HER2). Perillaldehyde 1,2-epoxide-loaded SLN (cPa-SLN), mean particle size (z-Ave) 275.31 ± 4.78 nm polydispersity index (PI) 0.303 0.081, were produced by high shear homogenization. An...
Introdução: As fraturas representam uma condição clínica significativa que demanda atenção médica e cuidados especializados, sendo das principais causas de morbidade mortalidade em todo o mundo. Objetivo: Investigar perfil dos pacientes deram entrada no Hospital Regional Lagarto com setor trauma-ortopédico, a fim compreender suas características demográficas, tipos fraturas, mecanismos lesão outros aspectos relevantes. Metodologia: Este estudo é caráter transversal observacional...
Compounds isolated from essential oils play an important role in the prevention and treatment of cancer. Monoterpenes are natural products, principal constituents many oils. The aim this study was to investigate cytotoxic potential p-menthane derivatives. Additionally, analogues perillyl alcohol, a monoterpene with known anticancer activity, were evaluated identify molecular characteristics which contribute their cytotoxicity, tested against OVCAR-8, HCT-116, SF-295 human tumor cell lines,...
Passiflora alata or passion fruit is a native flowering plant from Amazon, geographically spread Peru to Brazil. The has long been used in folks medicine for its pharmacological properties and included the Brazilian Pharmacopoeia since 1929. aim of this study was evaluate potential cytotoxic antitumor activities leaf extract (PaLE) S180-tumor bearing mice. percentage cell proliferation inhibition (% CPI) IC50 relation 4 tumor lines were determined PC3, K-562, HepG2 S180 using MTT assay. PaLE...
Recent studies have revealed the high cytotoxicity of p-menthane derivatives against human tumor cells. In this study, substance perillaldehyde 8,9-epoxide, a class derivative obtained from (S)-(−)-perillyl alcohol, was selected in order to assess antitumor activity experimental sarcoma 180 tumors. Toxicological effects related liver, spleen, kidneys and hematology were evaluated mice submitted treatment. The growth inhibition rate 38.4%, 58.7%, 35.3%, 45.4% 68.1% at doses 100 200 mg/kg/day...
Abstract Rotundifolone, a monoterpene isolated from the essential oil of leaves Mentha x villosa, is constituent several oils and known to have spasmolytic activity. The present study aimed investigate correlation between structure activity rotundifolone its analogues in ileum guinea-pig. Five seven tested were found effect more potent than itself, except for pulegone (+)-limonene. comparison limonene oxide showed that absence keto group did not decrease relaxant effect. Comparison...
Context: Toxicological screening of natural compounds for medicinal purposes.Objectives: The objective this study is to evaluate the toxicity methyl ferulate (MF), p-coumarate (MpC), and pulegone 1,2-epoxide (PE) with in vitro vivo assays.Materials methods: MF, MpC, PE was assessed at a concentration 10 mg/ml Ames assay using two strains Salmonella typhimurium TA98 TA100. Human red blood cells (RBC) were used determine hemolytic activity these compounds. cytotoxicity above determined brine...