A5051891398- Electronic Health Records Systems
- Advanced Drug Delivery Systems
- Medical Coding and Health Information
- Healthcare Systems and Technology
- biodegradable polymer synthesis and properties
- Advancements in Transdermal Drug Delivery
- Essential Oils and Antimicrobial Activity
- Pomegranate: compositions and health benefits
- Bone Tissue Engineering Materials
- Nanoparticle-Based Drug Delivery
- Proteins in Food Systems
- Natural Compound Pharmacology Studies
- Nanoparticles: synthesis and applications
- Lipid Membrane Structure and Behavior
- Botulinum Toxin and Related Neurological Disorders
- Electrospun Nanofibers in Biomedical Applications
- Plant Growth Enhancement Techniques
- Catalytic Processes in Materials Science
- Appendicitis Diagnosis and Management
- Pesticide Exposure and Toxicity
- Research on Leishmaniasis Studies
- Microencapsulation and Drying Processes
- Biochemical Analysis and Sensing Techniques
- Graphene and Nanomaterials Applications
- Collagen: Extraction and Characterization
Universidade de Sorocaba
2019-2024
University of Edinburgh
2010-2014
Hull and East Yorkshire Hospitals NHS Trust
2001
Hull Royal Infirmary
2001
Royal Liverpool and Broadgreen University Hospital NHS Trust
2001
Erasmus University Rotterdam
2001
<b>Objectives</b> To evaluate the implementation and adoption of NHS detailed care records service in "early adopter" hospitals England. <b>Design</b> Theoretically informed, longitudinal qualitative evaluation based on case studies. <b>Setting</b> 12 acute specialist settings studied over two a half years. <b>Data sources</b> Data were collected through depth interviews, observations, relevant documents relating directly to study sites wider national developments that perceived impact...
To describe and evaluate the implementation adoption of detailed electronic health records in secondary care England thereby provide early feedback for ongoing local national rollout NHS Care Records Service.A mixed methods, longitudinal, multisite, socio-technical case study.Five acute hospital mental trusts that have been focus efforts at which interim data collection analysis are complete. Data sources Dataset evaluation consists semi-structured interviews, documents field notes,...
Cosmetics composed of synthetic and/or semi-synthetic polymers, associated or not with natural exhibit a dashing design, thermal and chemo-sensitive properties. Cosmetic polymers are also used for the preparation nanoparticles delivery of, e.g., fragrances, purpose to modify their release profile reducing risk evaporation. Besides, other cosmetically active nutrients, dermal permeation enhancers, have been loaded into improve bioactivities on skin. The use in cosmetic formulations is...
Abstract Objectives Nanotechnology-based nasal delivery systems have gained interest as a way of overcoming low drug bioavailability, limited brain exposure, fast metabolism and elimination, high doses unwanted side effects. The main benefits intranasal (IN) administration include the non-invasive method, easy accessibility, porous epithelial barrier highly vascularized tissue. However, it is imperative to identify interactions between materials used biological environment ensure proper...
The therapeutic use of peptides has increasingly recognized in the development new therapies. However, susceptible enzymatic cleavage is a barrier that needs to overcome. Nose-to-brain delivery associated with liposomes can protect against biodegradation and improve accessibility brain targets. aim was develop liposomal formulation as ghrelin carrier. quality by design (QbD) approach used strategy for method development. initial risk assessments were carried out using fishbone diagram. A...
The aim of this study was to investigate the influence extraction method on dry extract yield guava leaves, correlating total phenolic content (TPC) with antioxidant activity. extracts were obtained from hydroethanolic (50 and 70%) using ultrasound-assisted method. Folin-Ciocalteau reagent used determine TPC. DPPH (2,2-diphenyl-1-picrylhydrazyl) in vitro assay ability scavenge free radicals. results analyses demonstrated that produced a higher both (11%), contrast conventional 50% solvent...
The aim of this study was to develop a dense lamellar scaffolding composed by collagen (COL), silk fibroin (SF) and polyethylene glycol 400 (PEG 400) evaluate the influence freezing parameters (−80, −50, −18 °C) associated with its plastic compression. physicochemical characterization developed scaffolds done mechanical morphological properties. Fourier Transform Infrared Spectroscopy (FTIR) Differential scanning calorimetry (DSC) showed crosslinking between PEG polymers, change in COL...
Regenerative medicine is an emerging field that aims in healing damaged tissue. The choice of the crosslinking agent one most critical requirements for development three-dimensional scaffold devices. This study aimed to investigate effects proanthocyanidins (PA) and glutaraldehyde (GA) associated with plastic compression method on properties dense lamellar. physiomechanical physical–chemical scaffolds were evaluated. antioxidant activity was investigated by 2,2-diphenyl-1-picrylhydrazyl...
The retina is a highly organized structure that considered to be "an approachable part of the brain." It attracting interest development scientists, as it provides model neurovascular system. Over last few years, we have been witnessing significant in knowledge mechanisms induce shape retinal vascular system, well disease processes lead degeneration. Knowledge and understanding how our vision works are crucial creating hardware-adaptive computational can replicate behavior. neuronal system...
The chemical processing of polymeric mixtures is a promising alternative for designing materials with new characteristics biomedical applications. This work proposed to produce and characterize obtained using polyethylene glycol (PEG400 or PEG4000) poly (L-co-D, L lactic acid)/PLDLA use. were prepared by the casting method. Characterizations performed Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), mechanical properties (perforation, resilience,...
<title>Abstract</title> Ulvan belongs to the class of sulfated heteropolysaccharide and is main component seaweed <italic>Ulva ohnoi</italic> (<italic>U. ohnoi</italic>). has a chemical structure similar fucoidan, chondroitin sulfate, hyaluronic acid, which are commonly used develop drug delivery systems. Due potential biomedical applications non-sulfated polysaccharides, this work aimed an environmentally friendly method for extracting ulvan from U. ohnoi with high yield purity. A novel...
A crescente valorização da aparência tem impulsionado a expansão área saúde estética, onde toxina botulínica (TxB) se destaca como uma alternativa eficaz aos procedimentos cirúrgicos para tratar rugas e linhas de expressão faciais. Este estudo revisou literatura sobre reconstituição TxB, utilizando bases dados PubMed, Scielo Google Acadêmico. TxB-A, disponível pó liofilizado, é reconstituída com diluentes estéreis, solução salina 0,9%, influenciando diretamente eficácia do tratamento. As...
Burns injuries induce a state of immunodepression that predisposes to bacterial infectious complication leads several comorbid diseases and high mortality rate. Previous studies about anti-inflammatory, antimicrobial antioxidant properties <em>Aloe vera</em> (L.) Burm., <em>Calendula officinalis</em> L. <em>Matricaria recutita</em> are acknowledge by effects.
A simple, fast, and selective HPLC method is presented to quantified amphotericin B (AmB) in a nose-to-brain nanoliposomal pharmaceutical formulation. The development was based on the design of experiments (DoE) approach. chromatographic analysis validated C18 Zorbax reversed-phase column (250 mm x 4,6 I.D.) with 5 µm particle size using mobile phase, consisting binary mixture ultra-purified water an organic composition acetonitrile, methanol, tetrahydrofuran (75:17:8, v/v). isocratic flow...
This study has been undertaken to investigate the influence of copolymers poly-L-co-D, L-lactic acid (PLDLA) 70:30 and Poly (ethylene glycol)-block-poly (propylene glycol) (P407) in transmural transport 3'-azido-3'-deoxythymidine (azidothymidine (AZT), zidovudine).Based on anterior studies we use proximal duodenum evaluate, vitro, apparent intestinal permeability.The binary solid dispersion (SD) was prepared with, AZT, PLDLA, P407.The supercritical antisolvent (SAS) technique used obtain SD,...
Pomegranate ( Punica granatum L .) is a polyphenols source, such as anthocyanins, punicalagin, ellagitannins and tannins. Polyphenols are antioxidant compounds present in foods cereals, fruits (peels, seeds juice), vegetables, wine, among others. responsible to protect cells limit the risks of degenerative tumoral diseases, well as, prevent cardiovascular neuronal important anti-inflammatory effects. The purpose this study was isolate from pomegranate juice using solvents without heating....