A5084417081- Advanced Drug Delivery Systems
- SARS-CoV-2 and COVID-19 Research
- Pomegranate: compositions and health benefits
- Advancements in Transdermal Drug Delivery
- COVID-19 Clinical Research Studies
- Analytical Chemistry and Chromatography
- Antimicrobial Peptides and Activities
- Seaweed-derived Bioactive Compounds
- Proteins in Food Systems
- Ocular Surface and Contact Lens
- Biochemical and Structural Characterization
- Biochemical Analysis and Sensing Techniques
- Medication Adherence and Compliance
- Liquid Crystal Research Advancements
- Advanced biosensing and bioanalysis techniques
- Conducting polymers and applications
- Nuclear Receptors and Signaling
- Heart rate and cardiovascular health
- Graphene research and applications
- Long-Term Effects of COVID-19
- Advanced Sensor and Energy Harvesting Materials
- COVID-19 Impact on Reproduction
- Biochemical effects in animals
- Regulation of Appetite and Obesity
- Drug Solubulity and Delivery Systems
Universidade de Sorocaba
2018-2024
Pontifícia Universidade Católica de São Paulo
2024
Universidade de São Paulo
2024
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2024
Abstract Objectives Nanotechnology-based nasal delivery systems have gained interest as a way of overcoming low drug bioavailability, limited brain exposure, fast metabolism and elimination, high doses unwanted side effects. The main benefits intranasal (IN) administration include the non-invasive method, easy accessibility, porous epithelial barrier highly vascularized tissue. However, it is imperative to identify interactions between materials used biological environment ensure proper...
The therapeutic use of peptides has increasingly recognized in the development new therapies. However, susceptible enzymatic cleavage is a barrier that needs to overcome. Nose-to-brain delivery associated with liposomes can protect against biodegradation and improve accessibility brain targets. aim was develop liposomal formulation as ghrelin carrier. quality by design (QbD) approach used strategy for method development. initial risk assessments were carried out using fishbone diagram. A...
Abstract Graphene is a two-dimensional carbon material with unique properties, such as high thermal and electrical conductivity, mechanical strength, elasticity, biocompatibility. The methods used to synthesize graphene affect its structural including flaws, layer count, crystalline domain size, impurities, ultimately affecting the properties performance of graphene-based materials. This review aims analyze characterize graphene, using both ISO/IEC standards current literature references....
The aim of this study was to investigate the influence extraction method on dry extract yield guava leaves, correlating total phenolic content (TPC) with antioxidant activity. extracts were obtained from hydroethanolic (50 and 70%) using ultrasound-assisted method. Folin-Ciocalteau reagent used determine TPC. DPPH (2,2-diphenyl-1-picrylhydrazyl) in vitro assay ability scavenge free radicals. results analyses demonstrated that produced a higher both (11%), contrast conventional 50% solvent...
The aim of the present study was to improve solubility and dissolution rate ibuprofen evaluate, ex vivo, intestinal permeation. Solid dispersions (SD) were prepared with Kollicoat IR® by solvent evaporation technique in different drug:carrier ratios. permeation evaluated inverted sac method. SD characterized equilibrium, FT-IR, DSC, PXRD, SEM, rate. solubility, rate, permeability significantly greater for 1:2. SEM DSC indicated a partial change crystalline state ibuprofen. equilibrium (1:2)...
<title>Abstract</title> Ulvan belongs to the class of sulfated heteropolysaccharide and is main component seaweed <italic>Ulva ohnoi</italic> (<italic>U. ohnoi</italic>). has a chemical structure similar fucoidan, chondroitin sulfate, hyaluronic acid, which are commonly used develop drug delivery systems. Due potential biomedical applications non-sulfated polysaccharides, this work aimed an environmentally friendly method for extracting ulvan from U. ohnoi with high yield purity. A novel...
Abstract Background Cancer therapy-related cardiac dysfunction frequently occurs in patients receiving anthracycline. Ivabradine reduces the heart rate without affecting contractility and has shown anti-inflammatory, antioxidant, antiapoptotic effects experimental models of cardiotoxicity. This study aims to evaluate effect ivabradine on cancer incidence with lymphoma or sarcoma treated Methods was a prospective, randomized, triple-blind trial. Patients starting anthracycline therapy were...
Objective: To evaluate the efficacy of pharmaceutical care in improving outcomes Brazilian outpatients with type 2 diabetes mellitus. Methods: In this single-blind, controlled trial, 71 were randomized into two groups: intervention (managed using pharmacotherapy follow-up protocol); and control standard dispensing procedures). Outcomes included hospitalization, severe complication (retinopathy, renal insufficiency, hypoglycemia, coronaropathy or foot lesion), values A1c hemoglobin (HbA1c),...
A simple, fast, and selective HPLC method is presented to quantified amphotericin B (AmB) in a nose-to-brain nanoliposomal pharmaceutical formulation. The development was based on the design of experiments (DoE) approach. chromatographic analysis validated C18 Zorbax reversed-phase column (250 mm x 4,6 I.D.) with 5 µm particle size using mobile phase, consisting binary mixture ultra-purified water an organic composition acetonitrile, methanol, tetrahydrofuran (75:17:8, v/v). isocratic flow...
Pomegranate ( Punica granatum L .) is a polyphenols source, such as anthocyanins, punicalagin, ellagitannins and tannins. Polyphenols are antioxidant compounds present in foods cereals, fruits (peels, seeds juice), vegetables, wine, among others. responsible to protect cells limit the risks of degenerative tumoral diseases, well as, prevent cardiovascular neuronal important anti-inflammatory effects. The purpose this study was isolate from pomegranate juice using solvents without heating....