Antimicrobial peptides (AMPs) are primarily known for their innate immune defense against invading microorganisms, including viruses. In addition, recent research has suggested modulatory activity in induction. Given that most subunit vaccines require an adjuvant to achieve effective induction through the activation of immunity, AMPs plausible candidate molecules stimulating not only but also adaptive responses.In this study, we investigated ability human β-defensin (HBD) 2 promote antiviral...

Abstract Predicting the risk of metastasis before starting prostate cancer (PCa) treatment can minimize overtreatment indolent cases and help choosing appropriate treatment. The levels circulating microRNAs (miRNAs) from body fluids be used as noninvasive prognostic biomarkers. In this study, urinary exosomal miRNA expression profiles 149 PCas were determined miRNAs associated with identified: miR-21, miR-16, miR-142-3p, miR-451, miR-636. When evaluating clinical factors together, miR-636,...

Abstract Oral mucosal vaccination is an alternative method to overcome the pitfalls of current injection-based vaccines, such as pain and high cost vaccination. It a feasible economic vaccine application, especially in developing countries. However, achieving effective antigen delivery into lymphoid organs efficient immune stimulation are prerequisites successful oral One promising approach for development exploring potential M cells via M-cell-targeting ligands that have deliver...

Silk peptide, the hydrolysate of silk protein derived from cocoons, has been employed as a biomedical material and is believed to be safe for human use.Silk peptide display various bioactivities, including anti-inflammatory, immune-regulatory, anti-tumor, anti-viral, anti-bacterial.Although earlier investigations demonstrated that stimulates macrophages production pro-inflammatory cytokines, its effect on natural killer (NK) cell function not yet explored.In this study, we initially...

Context: Ginkgo biloba L. (Ginkgoaceae) leaves have been used as an herbal medicine that has a complex range of biological activities. However, when we consider activity plant extracts is highly variable according to the source, location, and harvest season, technology obtain natural products with homogeneity extremely important.Objective: We established cambial meristematic cells (CMCs) biloba, which were expanded in vitro through suspension culture then determined anti-inflammatory...

Context: Silk peptide from cocoons of silkworm (Bombyx mori L., Bombycidae) has been employed as a biomedical material and exhibits various bioactivities, including immune-modulating activity.Objective: We analyzed whether silk exerts direct modulating effects on NK cells using an cell line in vitro ex vivo splenocytes. also attempted to delineate the mechanism underlying modulation.Material methods: In activity was determined by measurement cytolytic against K562 at effector-to-target ratio...

Ginkgo biloba leaves are traditionally ascribed a wide range of therapeutic attributes, including anti-oxidant, anti-cancer, and anti-inflammatory properties. We previously reported success in establishing expanding suspension cultures of G. biloba cambial meristematic cells (CMCs) in vitro, while maintaining genetic stability physiological homogeneity. In the present study, we tested anti-oxidant activities biloba CMCs using in vitro and in vivo assay systems. Results showed that ethanol...

Protein-calorie malnutrition is a common complication in cirrhosis. Protein restriction for the treatment of hepatic encephalopathy (HE) may cause disease progression and poor prognosis. Therefore, we evaluated important clinical parameters nutritional state cirrhotic patients with or without HE to predict development HE.Twenty-two were divided into two groups; group A-13 B-9 HE. Clinical biochemical parameters, serum proteins {serum albumin, insulin-like growth factor-1 (IGF-1),...

Ulcerative colitis (UC) is difficult to eradicate as it leads chronic inflammation in the digestive tract due immune system malfunction. The present study demonstrated protective effect of 7S,15R‑dihydroxy‑16S,17S‑epoxy‑docosapentaenoic acid (diHEP‑DPA), which had been previously synthesized, on a dextran sulfate sodium (DSS)‑induced BALB/c mouse model UC. UC was induced with 4% DSS drinking water for 7 days. Initially, anti‑inflammatory diHEP‑DPA confirmed by demonstrating that...

We have previously shown that SNU-1103, which is a latency type III Epstein-Barr virus (EBV)-transformed lymphoblastoid cell line (LCL) was developed from Korean cancer patient, resists serum starvation-induced G(1) arrest. In this study, we examined the role of latent membrane protein-1 (LMP-1) in starvation resistance, since LMP-1 known to be essential for EBV-mediated immortalization human B lymphocytes. The gene SNU-1103 introduced into EBV-negative BJAB line, and associated with...

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ABSTRACT Objectives Few studies have examined factors affecting steroid-free remission (SFR) in patients with immunoglobulin G4–related disease (IgG4-RD). The aim of this study was to investigate clinical SFR IgG4-RD. Methods medical records 68 who met the 2020 revised comprehensive diagnostic criteria for IgG4-RD were reviewed retrospectively. defined as maintained at least 6 months without corticosteroids. Cox regression analysis performed examine associations between and various factors....

Abstract Due to increasing concerns on the use of antibiotics in animal production system, development alternative strategies for disease control livestock and poultry is becoming important. Avian coccidiosis caused by several distinct species Eimeria which undergo intracellular different parts gut reducing significant nutrient absorption. Our previous studies have shown protection against using recombinant vaccines laboratory models. This study was carried out investigate effect immunizing...