A5072321835- Kawasaki Disease and Coronary Complications
- Phytoestrogen effects and research
- Food Quality and Safety Studies
- Coronary Artery Anomalies
- Mechanical Circulatory Support Devices
- Natural product bioactivities and synthesis
- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Natural Antidiabetic Agents Studies
- Phytochemicals and Antioxidant Activities
- Viral Infections and Immunology Research
- Pharmacological Effects of Natural Compounds
- Cardiac Arrest and Resuscitation
- Wound Healing and Treatments
- Probiotics and Fermented Foods
- Tracheal and airway disorders
- Cardiac Arrhythmias and Treatments
- Cardiac Valve Diseases and Treatments
- Phytochemistry and Bioactive Compounds
- NF-κB Signaling Pathways
- Respiratory and Cough-Related Research
- Asthma and respiratory diseases
- Congenital heart defects research
- Ethics and Legal Issues in Pediatric Healthcare
- Natural Products and Biological Research
Kyungpook National University
2016-2024
Kyungpook National University Hospital
2017-2024
Kyung Hee University
2016-2021
Pukyong National University
2017
Hanyang University
2017
Gachon University
2012-2016
Daegu University
2012
National Academy of Agricultural Science
2012
Kangwon National University
2012
Arizona State University
2009
The aim of this study was to develop docetaxel-incorporated lipid nanoparticles (DTX-NPs) improve the pharmacokinetic behaviour docetaxel (DTX) after oral and parenteral administration via sustained release. DTX-NPs were prepared by nanotemplate engineering technique with palmityl alcohol as a solid Tween-40/Span-40/Myrj S40 surfactants mixture. Spherical below 100 nm successfully narrow particle size distribution, 96% incorporation efficiency 686 times increase in DTX solubility. showed...
This report describes the synthesis of analogues 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (1), commonly known as bexarotene, and their analysis in acting retinoid X receptor (RXR)-specific agonists. Compound 1 has FDA approval to treat cutaneous T-cell lymphoma (CTCL); however, its use can cause side effects such hypothyroidism increased triglyceride concentrations, presumably by disruption RXR heterodimerization with other nuclear receptors. The novel...
Kawasaki disease, also known as mucocutaneous lymph node syndrome, is a common form of vasculitis in childhood. Among the recent trends it notable that prevalence rate increasing, and proportion “incomplete” disease increasing. A delayed diagnosis with prolonged fever can cause complications, such coronary artery aneurysm decreased myocardial contractility. These complications might lead to significant morbidity mortality. diagnosed when patient meets principal criteria for clinical...
Osteoarthritis (OA) is a degenerative chronic disease that affects various tissues surrounding the joints, such as subchondral bone and articular cartilage. The onset of OA associated with uncontrolled catabolic anabolic remodeling processes including cartilage bone, to adapt local biological biochemical signals. In this study, we determined whether 70% ethanolic (EtOH) extract Litsea japonica fruit (LJFE) had beneficial effects on cartilage, structural changes in tibial matrix degradation,...
Abstract: Three new large hexanuclear metalla-prisms 9–11 incorporating 1,3,5-tris(pyridin-4-ylethynyl)benzene (tpeb) 4 and one of the dinuclear arene ruthenium clips [Ru 2 ( p - i PrC 6 H Me) (OO∩OO)][CF 3 SO ] (OO∩OO =2,5-dioxydo-1,4-benzoquinonato [dobq] 1 , 5,8-dihydroxy-1,4-naphthaquinonato (donq) 6,11-dihydroxy-5,12-naphthacenedionato [dotq] ), which encapsulate guest molecule ellagic acid (2,3,7,8-tetrahydroxy-chromeno[5,4,3-cde]chromene-5,10-dione, 5) were prepared. All complexes...
Abstract: Nano-sized multinuclear ruthenium complexes have rapidly emerged as promising therapeutic candidates with unique anticancer activities. Here, we describe the coordination-driven self-assembly and activities of a set three organometallic tetranuclear Ru(II) molecular bowls. [2+2] Coordination-driven 3,6-bis(pyridin-3-ylethynyl)phenanthrene (bpep) ( 1 ) one dinuclear arene clips, [(ƞ 6 - p -iPrC H 4 Me) 2 Ru -(OO\OO)][OTf] (OO\OO =2,5-dioxido-1,4-benzoquinonato, OTf = triflate) ),...
Over the last decade, extracorporeal membrane oxygenation (ECMO) use in critically ill children has increased and is associated with favorable outcomes. Our study aims to evaluate current status of pediatric ECMO Korea, a specific focus on its volume changes survival rates based diagnostic indications.
본 연구에서는 까마귀쪽나무 잎과 열매 추출물의 항염증 활성을 비교하고자 마우스 대식세포주인 RAW 264.7 cell에서 LPS에 의해 유도된 COX-2/PGE2와 iNOS/NO 및 염증성 cytokine 인 TNF-<TEX>${\alpha}$</TEX>, IL-<TEX>$1{\beta}$</TEX>, IL-6의 생성 억제 정도를 확인하였다. 그 결과, 동일한 농도 조건(<TEX>$10{\mu}g/ml$</TEX>)에서 까마귀쪽나무의 추출물이 잎 추출물에 비해 NO, <TEX>$PGE_2$</TEX>, iNOS, cytokine인 생성량 모두에서 효능이 우수하게 나타났다. 따라서 까마귀쪽나무가 보여주는 효과적 측면과 안전성의 두가지 측면을 고려할 때, 저농도에서 추출물보다 효과가 우수하거나 동등하며, 안전성이 크다고 판단됨으로 열매추출물이 효능을 가진 기능성 식품 소재로써 개발 가능성이 있음을 제시한다. The present study aimed to investigate...
Purpose The present study aimed to evaluate progression and prognosis according the palliation method used in neonates early infants aged 3 months or younger who were diagnosed with pulmonary atresia ventricular septal defect (PA VSD) tetralogy of Fallot (TOF) severe stenosis (PS) a single tertiary hospital over period 12 years. Methods Twenty PA VSD 9 TOF PS needed initial palliation. Reintervention after palliation, complete repair, progress reviewed retrospectively. Results Among 29...
We aimed to evaluate the utility of serum ferritin level as an early screening test Kawasaki disease with macrophage activation syndrome (KD-MAS). analyzed levels on first day admission and clinical progress patients diagnosed complete or incomplete KD. Of 158 patients, 5 were KD-MAS. Conjunctival injection was significantly more frequent in KD group (p = 0.035), although there no significant differences other features. On admission, KD-MAS >500 ng/mL, which higher than that 0.001). In...
Context Diabetes is a common metabolic disease with long-term complications. Prunus mume Sieb. et Zucc. (Rosaceae) fruits have shown to ameliorate glucose intolerance. However, the antidiabetic effects of P. leaves not been investigated.Objective This study evaluated leaf 70% ethanol extract (PMLE) on alleviating diabetes in vivo and vitro.Materials methods PMLE was fractionated into n-hexane, dichloromethane (CH2Cl2), ethyl acetate (EtOAc), n-butanol (BuOH) water. Polyphenol flavonoid...
Supraventricular tachycardia (SVT) is one of the arrhythmias that can occur in newborns. Most SVT incidents neonatal period are spontaneously resolved around first year life, but since frequently before complete resolution, appropriate medication use required. However, no clear guidelines or consensus on treatment have been established yet.From January 2011 to December 2021, demographic data and antiarrhythmic medications used were retrospectively analyzed for 18 newborns diagnosed with at a...
Pueraria lobata is a perennial legume plant, widely distributed in the countries of East Asia. It medicinally important leguminous plant and produces various isoflavones such as puerarin, daidzein etc which have potential for preventing several chronic diseases including osteoporosis, cardiovascular disease cancer. In this study, we tried to induce hairy roots vitro from Korean wild arrowroot P. investigated effects hormones light conditions. Initially leaf stem segments were infected with...
Background and Objectives:The purpose of the present study was to investigate advantages disadvantages verifying genetic abnormalities using array comparative genomic hybridization (a-CGH) immediately after diagnosis congenital heart disease (CHD).Methods: Among neonates under age 28 days who underwent echocardiography from January 1, 2014 April 30, 2016, whose chromosomal were tested a-CGH in cases an abnormal finding on enrolled.Results: Of 166 patients diagnosed with CHD, 81 11 (11/81,...
Acetylsalicylic acid (ASA) is part of the recommended treatment Kawasaki disease (KD). Controversies remain regarding optimal dose ASA. We aimed to evaluate impact different doses ASA on inflammation control while minimizing adverse effects in acute phase KD.The enrolled 323 patients with KD were divided into three groups according dose: moderate-dose (30-50 mg/kg/day), high-dose (80-100 and non-ASA.High-dose group showed a significantly shorter duration fever from start remission than other...
고지혈증은 체내 지질대사에 이상이 생겨 혈중의 지질이 비정상적으로 높아진 상태로서, 필요 이상으로 혈액내 존재하게 되면 혈관벽에 쌓이고 굳어지게 되면서 동맥경화증, 고혈압, 뇌졸중 등의 심혈관계 질환을 일으키기도 한다. 본 연구에서는 고콜레스테롤 식이로 고지혈증을 유도한 생쥐의 동물모델에서 복분자 추출물의 유효성분인 protocatechuic acid(PCA)를 경구 투여하여 PCA의 간손상 보호 효과와 지질 대사함량 변화를 분석함으로써 고지혈증 치료에 대한 유의적인 임상 효과를 제시하였다. 투여는 식이에 의한 간무게 증가, 비장무게의 흉선의 위축, 신장의 위축 등 장기무게변화에 대하여 회복 보였고, 혈청 내 간세포 손상 마커 GPT 및 GOT의 나타내었으며, 총콜레스테롤, 중성지방, HDL, LDL의 지질대사산물의 profile에서도 회복효과를 보였다. 특히, 투여군에서는 혈중 HDL의 농도를 정상식이군 수준으로 높이고, 크게 낮추는 나타냄으로써 HDL/LDL의 균형유지에...
Background: The decision to use transannular patching (TAP) during tetralogy of Fallot (TOF) repair depends on the pulmonary valve annulus size; <i>z</i> score is most commonly used predictor. However, definitive results are not obtained with scores as different data sets for parameters.Purpose: This study aimed identify echocardiographic and other key factors that warranted a change in surgical method TOF surgery.Methods: Sixty-two patients were enrolled divided into (PV)...
As adolescents started to be vaccinated against coronavirus disease 2019 (COVID-19), suspected myocarditis and pericarditis related the vaccine were reported in adolescents. According Korea Disease Control Prevention Agency (KDCA), 2,796,270 persons aged 12−18 years fully by December 8. Among these, 9223 adverse events (0.33%). We aimed elucidate clinical courses short-term outcomes for with cardiac symptoms myo- or peri-carditis COVID-19 vaccination South Korea. Methods: retrospectively...
Herb extracts commercially used in Korea were screened for PPAR-<TEX>${\gamma}$</TEX> agonist test and <TEX>${\alpha}$</TEX>-glucosidase inhibition assay. Total 16 herb plants had a activity. Specially, Alisma orientale Juz (108.41%), Ephedra sinica (98.22%), Sasa japonica Makino var. purpurascens Nakai (140.68%), Astragalus membranaceus Bunge (106.79%) Cnidium officinale (113.00%) showed high activity rate compared with rosiglitazone's (167.46%). And Cornus officinalis S. et Z. (90.3%),...