A5041481890- Cellular transport and secretion
- Lipid Membrane Structure and Behavior
- Planetary Science and Exploration
- Robotics and Sensor-Based Localization
- Spacecraft Dynamics and Control
- Gaussian Processes and Bayesian Inference
- Autonomous Vehicle Technology and Safety
- Medical Imaging Techniques and Applications
- Force Microscopy Techniques and Applications
- Target Tracking and Data Fusion in Sensor Networks
- Space Exploration and Technology
- Inertial Sensor and Navigation
- Aortic Disease and Treatment Approaches
- Soil Moisture and Remote Sensing
- Cardiac Valve Diseases and Treatments
- Synthetic Aperture Radar (SAR) Applications and Techniques
- Advanced MRI Techniques and Applications
- Precipitation Measurement and Analysis
- Space Satellite Systems and Control
- Protein Structure and Dynamics
- Blockchain Technology Applications and Security
- Real-Time Systems Scheduling
- Gaze Tracking and Assistive Technology
- Cardiac Structural Anomalies and Repair
- Advanced biosensing and bioanalysis techniques
Chongqing Medical University
2025
Children's Hospital of Chongqing Medical University
2025
Columbia University Irving Medical Center
2021-2024
University of Pennsylvania
2021-2024
Manhattan College
2022-2024
California University of Pennsylvania
2024
Raytheon Technologies (Netherlands)
2022
Terra
2022
Stanford University
2021
Columbia University
2021
Abstract A specific group of transmembrane receptors, including the β1-adrenergic receptor (β1-AR), is internalized through a non-clathrin pathway known as Fast Endophilin Mediated Endocytosis (FEME). key question is: how does endocytic machinery assemble and it modulated by activated receptors during FEME. Here we show that endophilin, major regulator FEME, undergoes phase transition into liquid-like condensates, which facilitates formation multi-protein assemblies enabling partitioning...
Simulating blockchain technology within the IoT has never been as important. Along with this comes need to find suitable simulators capable of simulating networks an environment. Despite there being a wide variety simulators, not all are environment and for every This article will review previously published works present list well few untested that have potential simulate A total 18 presented discussed in paper. In addition, comprehensive advantages limitations each simulator is demonstrate...
View Video Presentation: https://doi.org/10.2514/6.2022-1214.vid The Mars 2020 Entry Descent and Landing (EDL) system delivered the Perseverance rover to surface of on February 18th, 2021. A large fraction Jezero Crater landing site was covered with hazards including cliffs, inescapable dune fields rocks. These were identified or inferred using orbital imagery before launch so that they could be avoided Terrain Relative Navigation (TRN) which composed two parts: Lander Vision System (LVS)...
Bayesian tomographic reconstruction algorithms generally require the efficient optimization of a functional many variables. In this setting, as well in other tasks, substitution (FS) has been widely applied to simplify each step iterative process. The function be minimized is replaced locally by an approximation having more easily manipulated form, e.g., quadratic, but which maintains sufficient similarity descend true while computing only substitute. We provide two new applications FS...
Since 2011, the Autonomous Descent and Ascent Powered-Flight Testbed (ADAPT) has been used to demonstrate advanced descent landing technologies onboard Masten Space Systems (MSS) Xombie vertical-takeoff, vertical-landing suborbital rocket. The current instantiation of ADAPT is a stand-alone payload comprising sensing avionics for terrain-relative navigation fuel-optimal planning large divert trajectories, thus providing complete pin-point capabilities needed planetary landers. To this end,...
Niemann-Pick Type C1 (NPC1) disease is a fatal neurovisceral disorder caused by dysfunction of NPC1 protein, which plays role in intracellular cholesterol trafficking. The cholesterol-chelating agent, 2-hydroxypropyl-β-cyclodextrin (HPβCD), currently undergoing clinical trials for treatment this disease. Though promising alleviating neurological symptoms, HPβCD causes irreversible hearing loss patients and outer hair cell (OHC) death animal models. We recently found that HPβCD-induced OHC...
Abstract Actin polymerization is essential in several clathrin-independent endocytic pathways including fast endophilin mediated endocytosis (FEME), however the actin machinery involved FEME has been elusive. Here, we show that polymerase VASP colocalizes and interacts directly with priming complex. We identify (EDP) as a binding partner establish novel non-canonical interactions between EDP EVH1 EVH2 domains of VASP. The major regulators lamellipodin (LPD) interact multivalently undergoing...
ISAAC is a highly capable, reusable, modular, and integrated FPGA-based common instrument control computing platform for wide range of needs as defined in the Earth Science National Research Council (NRC) Decadal Survey Report. This paper presents its motivation, technical approach, infrastructure elements. It also describes first prototype, I, application design SMAP L-band radar digital filter.
View Video Presentation: https://doi.org/10.2514/6.2022-0746.vid On February 18, 2021, the Perseverance Rover safely landed on Mars at Jezero Crater. Part of successful landing was due to Lander Vision System (LVS), which takes descent images from LVS Camera (LCAM) and IMU measurements estimates lander position relative a map site. The Simulation LCAM (LVSS LCAM) model is an image rendering program developed test in variety scenarios ensure performance amid uncertainty. LVSS includes...
The intracellular pH (pH<sub>i</sub>) of basilar artery rings was determined with 2’,7’-bis-(carboxyethyl)-5,(6)-carboxyfluorescein (BCECF) by measuring the ratio emitted (540 nm) fluorescence intensities (FI) at excitation wavelengths 500 and 440 nm. There a dye loss from in 90 min (39.3 ± 3.6%; p < 0.001). We found that does not adequately correct for loss; hence, we derived method to during pHi determinations. Calibration curves versus pH, were constructed rings. slope...
Statistical tomographic reconstruction algorithms generally require the efficient optimization of a functional. An algorithm known as iterative coordinate descent with Newton-Raphson updates (ICD/NR) has been shown to be much more computationally than indirect approaches based on EM algorithm. However, while ICD/NR experimentally converge stably, no theoretical proof convergence is known. We prove that modified algorithm, which we call ICD functional substitution (ICD/FS), guaranteed global...
Historically, computationally-intensive data processing for space-borne instruments has heavily relied on ground-based computing resources. But with recent advances in functional densities of Field-Programmable Gate-Arrays (FPGAs), there been an increasing desire to shift more on-board; therefore relaxing the downlink bandwidth requirements. Fast Fourier Transforms (FFTs) are commonly-used building blocks applications, a growing need increase FFT block size. Many existing architectures have...
We proposed a Client Server Based Plastic Fiber Optic Network for an Elderly Support system in smart home environment. The network will incorporate multimodal dialogue systems (MDS) and Artificial Intelligence (AI) systems. Existing AI models like GPT Vicuna be used further trained to support the elderly home. MDS systems, Whisper Lavis, act as intermediaries between POF of sensors convert video audio files into information that can process respond to. network, consisting client-server...
Abstract Kidney anomalies (KA) are developmental disorders that commonly cause pediatric chronic kidney disease and mortality. We examined rare coding variants in 248 KA trios 1,742 singleton cases compared them to 22,258 controls. Diagnostic candidate diagnostic were detected 14.1% of cases. a significant enrichment damaging constrained genes expressed during development associated with other disorders, suggesting phenotype expansion. Consistent these data, 18% patients had...
Geographic location, environmental properties, and altitude are factors that contribute to the increase or decrease of pedestrians ultraviolet (UV) exposure. Over-exposure can cause severe skin damage, possibly leading cancer. This work proposes an algorithm for estimating UVA UVB exposure along a path in urban environment before stepping outdoors. The is incorporated into our UV Guardian (UVG) system. For all pedestrian walk experiments conducted, results show proposed estimates with 94%...
Abstract A specific group of transmembrane receptors, including the β1-adrenergic receptor (β1-AR), is internalized through a non-clathrin pathway known as Fast Endophilin Mediated Endocytosis (FEME). key question is: how does endocytic machinery assemble and it modulated by activated receptors during FEME. Here we show that endophilin, major regulator FEME, undergoes phase transition into liquid-like condensates, which facilitates formation multi-protein assemblies enabling partitioning...
Future urban transportation concepts include a mixture of ground and air vehicles with varying degrees autonomy in congested environment. In such dynamic environments, occupancy maps alone are not sufficient for safe path planning. Safe efficient requires reasoning about the 3D flow traffic properly modeling uncertainty. Several different approaches can be taken developing velocity maps. This paper explores Bayesian approach that captures our uncertainty map given training data. The involves...
An approach for algorithm specifications and development is described SMAP's radar onboard processor with multi-stage demodulation decimation bandpass digital filter. Point target simulation used to verify validate the filter design usual performance parameters. Preliminary FPGA implementation also discussed.