A5020830083- Plant-Microbe Interactions and Immunity
- Plant Virus Research Studies
- Plant Parasitism and Resistance
- Transgenic Plants and Applications
- Plant Pathogens and Fungal Diseases
- Plant Stress Responses and Tolerance
- Insect-Plant Interactions and Control
- Plant Molecular Biology Research
- Plant Pathogenic Bacteria Studies
- Mycotoxins in Agriculture and Food
- Immune Cell Function and Interaction
- Genomics, phytochemicals, and oxidative stress
- Immune Response and Inflammation
- Animal Virus Infections Studies
- Phytochemical compounds biological activities
- Insect behavior and control techniques
- Herbal Medicine Research Studies
- Wheat and Barley Genetics and Pathology
- Photosynthetic Processes and Mechanisms
- Legume Nitrogen Fixing Symbiosis
- Circadian rhythm and melatonin
- Plant-derived Lignans Synthesis and Bioactivity
- Chromosomal and Genetic Variations
- Toxin Mechanisms and Immunotoxins
- Diabetes and associated disorders
University of British Columbia
2016-2025
Canada's Michael Smith Genome Sciences Centre
2016-2025
University of California, Los Angeles
2023
Howard Hughes Medical Institute
2023
Northwest A&F University
2013-2014
University of Minnesota
2005
Twin Cities Orthopedics
2005
Summary Higher plants utilize nucleotide‐binding leucine‐rich repeat domain proteins ( NLR s) as intracellular immune receptors to recognize pathogen‐derived effectors and trigger a robust defense. The Activated Disease Resistance 1 ADR 1) family of coiled‐coil s CNL have evolved helper that function downstream many TIR ‐type sensor TNL s). Close homologs 1s form the N REQUIREMENT GENE NRG in Arabidopsis , which is unclear. Through CRISPR /Cas9 gene editing methods, we discovered tandemly...
Sexual reproduction plays a critical role in the infection cycle of Fusarium graminearum because ascospores are primary inoculum. As homothallic ascomycete, F. contains both MAT1-1 and MAT1-2-1 loci genome. To better understand their functions regulations sexual pathogenesis, this study we assayed expression, interactions, mutant phenotypes individual MAT locus genes. Whereas expression MAT1-1-1 MAT12-1 rapidly increased after perithecial induction began to decline 1 day post-perithecial...
SYSTEMIC ACQUIRED RESISTANCE DEFICIENT 1 (SARD1) and CALMODULIN-BINDING PROTEIN 60g (CBP60g) are two master transcription factors that regulate many defense-related genes in plant immunity. They required for immunity downstream of the receptor-like protein SUPPRESSOR OF NPR1-1, CONSTITUTIVE 2 (SNC2). Constitutive defense responses gain-of-function autoimmune
The rice blast fungus Magnaporthe oryzae is a model for studying fungal–plant interactions. Although it produces two types of spores (microconidia and macroconidia), previous infection studies have exclusively dealt with macroconidia. Germination microconidia has not been reported, their role in plant defined. Here we show that approximately 10% germinate on surfaces, colonies derived from germinated are normal growth pathogenesis. In assays barley seedlings, fail to infect intact plants,...
Both plants and animals utilize nucleotide-binding leucine-rich repeat immune receptors (NLRs) to perceive the presence of pathogen-derived molecules induce responses. NLR genes are far more abundant diverse in vascular than animals. Truncated NLRs, which lack one or canonical domains, also commonly encoded plant genomes. However, little is known about their functions, especially N-terminally truncated ones. Here, we show that Arabidopsis thaliana helper (hNLR) gene N REQUIREMENT GENE1...
Plant immunity is tightly regulated to ensure proper defense against surrounding microbial pathogens without triggering autoimmunity, which negatively impacts plant growth and development. Immune receptor levels are intricately controlled by RNA processing post-translational modification events, such as ubiquitination. It remains unknown whether, if yes, how, immune homeostasis at the translational level. From a mutant, snc1-enhancing (muse) forward genetic screen, we identified MUSE11/EXA1,...
Abstract Plant immune responses are mainly activated by two types of receptors. Plasma membrane-localized pattern recognition receptors (PRRs) recognize conserved features microbes, and intracellular nucleotide-binding leucine rich repeat (NLRs) effector proteins from pathogens. NLRs possessing N-terminal Toll/interleukin-1 receptor (TIR) domains (TNLs) activate parallel signaling pathways via the EDS1/PAD4/ADR1s EDS1/SAG101/NRG1s modules. The relationship between PRR-mediated...
In humans and plants, 40% of the proteome is cotranslationally acetylated at N-terminus by a single Nα-acetyltransferase (Nat) termed NatA. The core NatA complex comprised catalytic subunit 10 (NAA10) ribosome-anchoring NAA15. regulatory Huntingtin Yeast Partner K (HYPK) acetyltransferase NAA50 join this in humans. Even though both are conserved Arabidopsis (Arabidopsis thaliana), only AtHYPK known to interact with AtNatA. Here we uncover AtNAA50 interactome provide evidence for association...
Abstract The H3 methyltransferases ATXR5 and ATXR6 deposit H3.1K27me1 to heterochromatin prevent genomic instability transposon re-activation. Here, we report that atxr5 atxr6 mutants display robust resistance Geminivirus. viral is correlated with activation of DNA repair pathways, but not re-activation or amplification. We identify RAD51 RPA1A as partners virus-encoded Rep protein. two proteins show increased binding heterochromatic regions defense-related genes in vs wild-type plants....
Abstract Both plants and animals use nucleotide-binding leucine-rich repeat (NLR) immune receptors to perceive pathogens trigger immunity. Toll/interleukin-1 receptor (TIR)-type plant NLRs (TNLs) require the lipase-like protein family members Enhanced Disease Susceptibility 1 (EDS1)/ Phytoalexin Deficient 4 (PAD4)/ Senescence-Associated Gene 101 (SAG101) helper (hNLRs) for downstream signaling, biochemical mechanisms of which remain unclear. Here, we report that TIR signaling promotes...
Abstract Both animals and plants utilize nucleotide-binding leucine-rich repeat immune receptors (NLRs) to perceive the presence of pathogen-derived molecules induce responses. NLR genes are far more abundant diverse in higher plants. Interestingly, truncated NLRs, which lack one or canonical domains, also commonly encoded plant genomes. However, little is known about their functions, especially regarding N-terminally ones. Here, we show that Arabidopsis thaliana ( A. ) helper gene NRG1C N...
Stringent modulation of immune signaling in plants is necessary to enable a rapid response pathogen attack without spurious defense activation. To identify genes involved plant immunity, forward genetic screen for enhancers the autoimmune snc1 (suppressor npr1, constitutive 1) mutant was conducted. The contains gain-of-function mutation gene encoding NOD-like receptor (NLR) protein. isolated muse7 (mutant, snc1-enhancing, 7) shown confer reversion phenotypes wild-type-like mos4 (modifier...
Abstract Arabidopsis SYSTEMIC ACQUIRED RESISTANCE DEFICIENT 1 (SARD1) and CALMODULIN-BINDING PROTEIN 60g (CBP60g) are two master transcription factors that regulate many defense-related genes in plant immunity. They required for immunity downstream of the receptor-like protein SUPPRESSOR OF NPR1-1, CONSTITUTIVE 2 (SNC2). Constitutive defense responses gain-of-function autoimmune snc2-1D mutant modestly affected by either sard1 or cbp60g single mutants, but completely suppressed double...