A5050992259- Neonatal and fetal brain pathology
- Advanced Neuroimaging Techniques and Applications
- EEG and Brain-Computer Interfaces
- Vascular Malformations Diagnosis and Treatment
- Synthesis and biological activity
- Electron Spin Resonance Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disorders and Treatments
- Diet, Metabolism, and Disease
- Synthesis of Organic Compounds
- T-cell and Retrovirus Studies
- IgG4-Related and Inflammatory Diseases
- Glioma Diagnosis and Treatment
- Photoreceptor and optogenetics research
- Esophageal Cancer Research and Treatment
- Neuroscience of respiration and sleep
- Neurological disorders and treatments
- Nuclear Receptors and Signaling
- RNA regulation and disease
- Cerebral Venous Sinus Thrombosis
- Click Chemistry and Applications
- Lung Cancer Diagnosis and Treatment
- Nerve injury and regeneration
- Macrophage Migration Inhibitory Factor
- Biological Activity of Diterpenoids and Biflavonoids
Presbyterian Medical Center
2024
Gwangju Institute of Science and Technology
2016-2020
Seoul National University Bundang Hospital
2020
Glucose hypometabolism in cortical structures after functional disconnection is frequently reported patients with white matter diseases such as subcortical stroke. However, the molecular and cellular mechanisms have been poorly elucidated. Here we show, an animal model of internal capsular infarct, that GABA-synthesizing reactive astrocytes distant areas cause glucose via tonic inhibition neighboring neurons. We find reversal aberrant astrocytic GABA synthesis, by pharmacological...
(Cell Reports 32, 107861-1–14.e1–e7; July 7, 2020) In the originally published version of this article, author name Jung Moo Lee was spelled incorrectly. This has now been corrected online. The authors regret error. Excessive Astrocytic GABA Causes Cortical Hypometabolism and Impedes Functional Recovery after Subcortical StrokeNam et al.Cell ReportsJuly 07, 2020In BriefNam al. demonstrate that excessive from reactive astrocytes accounts for cortical glucose hypometabolism followed by...
Subcortical capsular stroke has a poor prognosis, and it is not yet fully understood how under what circumstances reach training contributes to motor recovery. Objective This study was performed investigate changes in neuronal circuits recovery chronic model the presence or absence of training.We generated photothrombotic lesions 42 Sprague-Dawley rats evaluated with without daily single-pellet reaching task (SPRT). We used 2-deoxy-2-[18F]-fluoro-D-glucose-microPET (positron emission...
Recently, several capsular stroke models have been reported with different targets of destruction. This study was performed to establish an accurate internal capsule (IC) target for modeling in rats. We injected adeno-associated virus serotype 5 (AAV)-CaMKII-EYFP into forelimb motor cortex and AAV-CaMKII-mCherry hindlimb (n = 9) anterogradely trace the pyramidal fibers map their somatotopic distribution IC. On basis neural tracing results, we created photothrombotic infarct lesions rat fiber...
Recent increase in the prevalence rate of white matter stroke demands specific research field. However, lack a pertinent animal model for has hampered investigations. Here, we describe novel method creating circumscribed capsular infarct that minimizes damage to neighboring gray structures. We used pre-surgery neural tracing with adeno-associated virus-green fluorescent protein (AAV-GFP) identify somatotopic organization forelimb area within internal capsule. The adjustment light intensity...
Mediastinal vascular malformations are rare and their diagnosis can be challenging. Imaging is vital for diagnosing mediastinal help avoid unnecessary invasive procedures. Herein, we report the detailed CT MRI findings of a low-flow malformation in an asymptomatic 63-year-old male.
The brain grows with age in non-human primates (NHPs). Therefore, atlas-based stereotactic coordinates cannot be used directly to target subcortical structures if the size of animal's differs from that atlas. Furthermore, growth is non-uniform across different cortical regions, making it difficult simply apply a single brain-expansion ratio. We determined skull reference lines best reflect changes along X, Y, and Z axes plotted reference-line length against body weight. had linear...
Vascular endothelial cells are essential to vascular function and maintenance. Dysfunction of these can lead the development cardiovascular disease or contribute tumorigenesis. As such, therapeutic modulation monitoring significant clinical interest, several endothelial-specific ligands have been developed for drug delivery function. However, application has limited by their high cost tendency induce immune responses, highlighting a need alternate methods targeting cells. In present study,...
Recent increase in the prevalence rate of white matter stroke demands specific research field. However, lack a pertinent animal model for has hampered investigations. Here, we describe novel method creating circumscribed capsular infarct that minimizes damage to neighboring gray structures. We used pre-surgery neural tracing with adeno-associated virus-green fluorescent protein (AAV-GFP) identify somatotopic organization forelimb area within internal capsule. The adjustment light intensity...
Traditional pyramidotomy models have a high mortality rate from breathing difficulties and show early recovery the induced motor deficits. This study establishes novel technique in Sprague Dawley rats that generates persistent deficits has reduced rate. We used viral neural tracing to identify course relative distribution of forelimb hindlimb fibers (n = 9). On basis data, medullary pyramid was targeted dorsally cerebellar cortex for photothrombotic infarct lesioning 18). The selectively...
Aims Endoscopic ultrasound (EUS) is a suitable device for staging of esophageal cancers. However, chest computed tomography (CT) has traditionally been the standard diagnostic modality malignancies. This study aimed was to compare accuracies EUS and CT in T N