A5024201826- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Immunotherapy and Immune Responses
- Mesenchymal stem cell research
- Neuroinflammation and Neurodegeneration Mechanisms
- Nanoplatforms for cancer theranostics
- Botulinum Toxin and Related Neurological Disorders
- Nuclear Receptors and Signaling
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Transcranial Magnetic Stimulation Studies
- Cancer Research and Treatments
- Autism Spectrum Disorder Research
- Circular RNAs in diseases
- Traumatic Brain Injury Research
- Pituitary Gland Disorders and Treatments
- Vascular Malformations Diagnosis and Treatment
- Electrospun Nanofibers in Biomedical Applications
- Neuroscience and Neural Engineering
- Genomics, phytochemicals, and oxidative stress
- Barrier Structure and Function Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Connexins and lens biology
Nanchang University
2015-2025
First Affiliated Hospital of Jiangxi Medical College
2024-2025
First Affiliated Hospital of Nanchang University
2014-2024
University of South Carolina
2018
The University of Texas MD Anderson Cancer Center
2018
Southern Medical University
2010-2014
Zhujiang Hospital
2011-2014
UConn Health
1993
Abstract Parkinson's disease (PD) is the most prevalent neurodegenerative disorder. Neuroinflammation mediated by activated microglia and apoptosis of dopaminergic (DA) neurons in midbrain are its primary pathological manifestations. Leucine‐rich repeat protein kinase 2 (LRRK2) has been observed to increase expression during neuroinflammation, however, effect LRRK2 on activation remains poorly understood. In this study, we have established lipopolysaccharide (LPS) treated BV2 cells...
To explore the causal relationship between physical activity (PA) and progression of Parkinson's disease (PD), we conducted a two-sample Mendelian randomization (MR) analysis. Genetic variants were obtained from publicly available genome-wide association study (GWAS) summary statistics for PA (N = 377,000), age at onset 28,568), PD 4093). Causal estimates calculated using inverse variance weighted (IVW) method, with MR-Egger median analyses performed to assess robustness results. Genetically...
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder worldwide, characterized by progressive degeneration of dopaminergic neurons in substantia nigra pars compacta and abnormal aggregation α-synuclein (α-syn). Despite extensive research, mechanisms underlying microglial-mediated neuroinflammation ferroptosis PD remain inadequately understood. In particular, role leucine-rich repeat kinase 2 (LRRK2) microglial cells its modulation p62-Keap1-Nrf2 signaling pathway...
Parkinson’s disease (PD) is one of the most prevalent neurodegenerative disorders characterized by motor and nonmotor symptoms due to selective loss midbrain dopaminergic neurons. Pharmacological surgical interventions have not been possible cure PD; however, cause neurodegeneration remains unclear. Here, we performed tested a multitiered bioinformatic analysis using GEO Proteinexchange database investigate gene expression involved in pathogenesis PD. Then further validated individual...
Glioma is the most common malignant primary brain tumor, and it has a poor prognosis. Studies have shown that cryoablation can activate antitumor immunoeffects by promoting augmentation of dendritic cells (DCs). Granulocyte macrophage colony-stimulating factor (GM-CSF) been to be useful for immunotherapy against glioma because stimulate DCs present tumor antigen. Previous studies GM-CSF exert effects. To test hypothesis combined therapy with could synergistically improve specific antiglioma...
Background. The relationship between the levodopa challenge test (LDCT) and postoperative subthalamic nucleus-deep brain stimulation (STN-DBS) benefits is controversial in patients with Parkinson’s disease (PD). We aim to evaluate value of total response (TLR) symptom (SLR) predicting improvement different PD motor subtypes. Methods. Studies were split into a training set (147 patients) validation (304 patients). retrospectively collected data from 147 who received Unified Disease Rating...
Parkinson's disease is a neurodegenerative disorder with an inflammatory response as the core pathogenic mechanism. Previous human genetics findings support view that loss of TREM2 function will aggravate neurodegeneration, and one most highly expressed receptors in microglia. However, role mechanism PD not clear. In our study, it was found both
Abstract Background Gap junctions are involved in the development of cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH). However, specific roles and regulatory functions related connexin isoforms remain unknown. The aim this study was to investigate importance 43 (Cx43) CVS determine whether Cx43 alterations modulated via protein kinase C (PKC) signaling transduction pathway. Methods Oxyhemoglobin (OxyHb)-induced smooth muscle cells basilar arterial second-injection model rat were...
Dendritic cells (DCs) are highly specialized antigen-presenting that play a key role in the activation of naive T cells. With an aim to explore whether in-situ administration DCs following argon-helium cryosurgery could enhance specific antiglioma immunity mice, we evaluated validity this approach murine subcutaneous GL261 glioma model. C57BL/6 mice models bearing were established and then divided into four groups, namely, no-treatment group (n=14), DC (n=15), cryosurgery+DC (n=15). Compared...
Dendritic cells (DCs) are potent antigen-presenting that play a critical role in priming tumor immune responses. We investigated the mechanisms of antitumor efficacy DCs pulsed with argon–helium-cryotreated glioma cells. There was significant upregulation maturation markers (CD80, CD86, MHC-I, and MHC-II) argon–helium freeze–thawed lysate-pulsed DCs. The concentration interleukin-6 (IL-6), IL-1β, necrosis factor-α, IL-12 secreted by increased. interferon-γ T stimulated cytotoxicity assay...