A5021569070- interferon and immune responses
- Immune Cell Function and Interaction
- Neuropeptides and Animal Physiology
- Chemical Synthesis and Analysis
- Peptidase Inhibition and Analysis
- Ubiquitin and proteasome pathways
- Glycosylation and Glycoproteins Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Genetics, Bioinformatics, and Biomedical Research
- Phagocytosis and Immune Regulation
- Galectins and Cancer Biology
- Immune Response and Inflammation
- Inflammasome and immune disorders
- vaccines and immunoinformatics approaches
- Click Chemistry and Applications
- CAR-T cell therapy research
- Pain Mechanisms and Treatments
- Biomedical Research and Pathophysiology
- Health, Environment, Cognitive Aging
- Carbohydrate Chemistry and Synthesis
- Cytomegalovirus and herpesvirus research
- Respiratory viral infections research
- Cancer therapeutics and mechanisms
- Mast cells and histamine
- Animal Genetics and Reproduction
The Ohio State University
2021-2024
Yuxian People's Hospital
2017
Nanjing University
2015
Allen Institute
2008
Allen Institute for Brain Science
2008
Amgen (United States)
2007-2008
Array BioPharma (United States)
2007
Merck & Co., Inc., Rahway, NJ, USA (United States)
2004-2005
Mitochondria, a highly metabolically active organelle, have been shown to play an essential role in regulating innate immune function. Mitochondrial Ca
The O -GlcNAc transferase (OGT) is an essential enzyme that mediates protein -GlcNAcylation, a unique form of posttranslational modification many nuclear and cytosolic proteins. Recent studies observed increased OGT -GlcNAcylation levels in broad range human cancer tissues compared to adjacent normal tissues, indicating universal effect promoting tumorigenesis. Here, we show for tumor growth immunocompetent mice by repressing the cyclic GMP-AMP synthase (cGAS)-dependent DNA sensing pathway....
The O -GlcNAc transferase (OGT) is an essential enzyme that mediates protein -GlcNAcylation, a unique form of posttranslational modification many nuclear and cytosolic proteins. Recent studies observed increased OGT -GlcNAcylation levels in broad range human cancer tissues compared to adjacent normal tissues, indicating universal effect promoting tumorigenesis. Here, we show for tumor growth immunocompetent mice by repressing the cyclic GMP-AMP synthase (cGAS)-dependent DNA sensing pathway....
The bradykinin B1 receptor is induced following tissue injury and/or inflammation. Antagonists of this have been studied as promising candidates for treatment chronic pain. We identified aryl sulfonamides containing a chiral chroman diamine moiety that are potent antagonists the human receptor. Our previously communicated lead, compound 2, served proof-of-concept molecule, but suffered from poor pharmacokinetic properties. With guidance metabolic profiling, we performed structure−activity...
Abstract The uptake of Ca 2+ into and extrusion calcium from the mitochondrial matrix, regulated by uniporter (MCU), is a fundamental biological process that has crucial impacts on cellular metabolism, signaling, growth survival. Herein, we report embryonic lethality Mcu -deficient mice fully rescued orally supplementing ferroptosis inhibitor lipophilic antioxidant vitamin E ubiquinol. Mechanistically, found MCU promotes acetyl-CoA-mediated GPX4 acetylation at K90 residue, K90R mutation...
Abstract The O -GlcNAc transferase (OGT) is an essential enzyme that mediates protein -GlcNAcylation, a unique form of posttranslational modification many nuclear and cytosolic proteins. Recent studies observed increased OGT -GlcNAcylation levels in broad range human cancer tissues compared to adjacent normal tissues, indicating universal effect promoting tumorigenesis. Here, we show for tumor growth immunocompetent hosts by repressing the cyclic GMP-AMP synthase (cGAS)-dependent DNA sensing...
The O -GlcNAc transferase (OGT) is an essential enzyme that mediates protein -GlcNAcylation, a unique form of posttranslational modification many nuclear and cytosolic proteins. Recent studies observed increased OGT -GlcNAcylation levels in broad range human cancer tissues compared to adjacent normal tissues, indicating universal effect promoting tumorigenesis. Here, we show for tumor growth immunocompetent hosts by repressing the cyclic GMP-AMP synthase (cGAS)-dependent DNA sensing pathway....
The O -GlcNAc transferase (OGT) is an essential enzyme that mediates protein -GlcNAcylation, a unique form of posttranslational modification many nuclear and cytosolic proteins. Recent studies observed increased OGT -GlcNAcylation levels in broad range human cancer tissues compared to adjacent normal tissues, indicating universal effect promoting tumorigenesis. Here, we show for tumor growth immunocompetent hosts by repressing the cyclic GMP-AMP synthase (cGAS)-dependent DNA sensing pathway....
Abstract Challenge of host cells with viral pathogens induces robust metabolic reprogramming; however, whether component(s) is detected by enzyme remains completely unknown. Our previous study identified the O-GlcNAc transferase (OGT), an important glucose enzyme, as a crucial mediator MAVS-dependent antiviral response. Here, studying mouse model enzyme-inactive OGT, we demonstrate enzyme-independent function OGT in limiting influenza A virus (IAV) infection, addition to its enzyme-dependent...
Objective To assess the efficacy and safety of nebulized hypertonic saline solution in infant with bronchiolitis. Methods From January 2014 to 2016, 95 patients at 3-13 months old our hospital who diagnosed as bronchiolitis were randomly divided into three groups.On basis conventional suit support treatment, observation group A was given 3% (n=32), B salbutamol control C normal saline(0.9%) (n=31), this therapy repeated every 6 hours until discharge.The Lowell score, clinical symptoms...