A5014493410- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Syphilis Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Reproductive tract infections research
- HIV-related health complications and treatments
- Sex work and related issues
- HIV, TB, and STIs Epidemiology
- Hepatitis C virus research
- Cardiac Valve Diseases and Treatments
- Adolescent Sexual and Reproductive Health
- Pregnancy and Medication Impact
- Trauma and Emergency Care Studies
- Breastfeeding Practices and Influences
- Health Services Management and Policy
- Homelessness and Social Issues
- Hepatitis Viruses Studies and Epidemiology
- Disaster Response and Management
- Herpesvirus Infections and Treatments
- Cardiac and Coronary Surgery Techniques
- Genital Health and Disease
- Antiplatelet Therapy and Cardiovascular Diseases
- Poxvirus research and outbreaks
Health Service Executive
2017-2024
St. James's Hospital
2013-2023
National Institute of Standards and Technology
2016
Guy's and St Thomas' NHS Foundation Trust
2006-2008
St Thomas' Hospital
2006-2007
King's College London
2006
Pitié-Salpêtrière Hospital
2005
Sorbonne Université
2005
Papworth Hospital
2005
Hospital Universitari Germans Trias i Pujol
2005
The use of antiretroviral therapy during pregnancy is important for control maternal human immunodeficiency virus (HIV) disease and the prevention perinatal HIV transmission. Physiological changes can reduce exposure. We studied pharmacokinetics rilpivirine 25 mg once daily in HIV-1-infected women late pregnancy.We conducted a nonrandomized, open-label, multicenter, phase 4 study. HIV-infected pregnant receiving were included. Intensive 24-hour pharmacokinetic sampling was performed third...
In February 2015, an outbreak of recently acquired HIV infections among people who inject drugs (PWID) was identified in Dublin, following similar outbreaks Greece and Romania 2011. We compared drug risk behaviours 15 cases 39 controls. Injecting a synthetic cathinone, snow blow, associated with recent infection (AOR: 49; p=0.003). Prevention control efforts are underway PWID but may also be needed elsewhere Europe.
BackgroundMpox, caused by monkeypox virus (MPXV), was considered a rare zoonotic disease before May 2022, when global epidemic of cases in non-endemic countries led to the declaration Public Health Emergency International Concern. Cases mpox Ireland, country without previous reports, could reflect extended local transmission or multiple epidemiological introductions.AimTo elucidate origins and molecular characteristics MPXV circulating Ireland between 2022 October 2023.MethodsWhole genome...
Antenatal antiretroviral therapy is integral to preventing vertical transmission of HIV-1. The impact temporary triple in pregnancy on the emergence resistance has not been studied.To determine resistance.Pregnant HIV-1 infected women with a pre-treatment CD4 cell count >300 x 10(6)/l initiated third trimester and discontinued postpartum. Genotypic testing was performed after cessation pretreatment samples when postpartum showed primary mutations.In cohort 50 who pregnancy, 39 (78%) had...
Objectives To describe the maternal tolerability of nevirapine as part combination antiretroviral therapy in pregnancy at three HIV centres Dublin, Ireland and to determine risk factors for development significant hepatotoxicity. Methods A retrospective study was carried out all women prescribed (October 2000 February 2003). Toxicities experienced were graded according Division AIDS toxicity guidelines adults. Statistical analysis performed whether there differences between those that did...
ObjectivesTo describe the pharmacokinetics of darunavir in pregnant HIV-infected women third trimester and post-partum.
Pharmacokinetic and efficacy data on dolutegravir in pregnant women living with human immunodeficiency virus (HIV) are still limited but needed to support its use as one of the preferred antiretroviral agents. Within multicenter Pharmacokinetics ANtiretroviral agents HIV-infected pregNAnt (PANNA) study, HIV using once daily (50 mg, food) underwent 24-hour pharmacokinetic profiling their third trimester postpartum. Dolutegravir exposure was considered adequate if geometric mean unbound,...
In 2000, a syphilis outbreak was identified in Ireland.A prospective enhanced database established 2000. Crude incidence rates for the general population, men who have sex with (MSM), and HIV-positive MSM were calculated.Three hundred fifty-six cases of infectious diagnosed at 1 center. Eighty-five percent as MSM. MSM, ranging age between 20 44 years, peaked 2001 719 per 100000 population. A total 17.4% occurred HIV-infected individuals. center increased to 7280 100000. Similar percentages...
The aim was to summarize national prevention of mother-to-child transmission (PMTCT) guidelines across Europe and identify differences between these.A survey conducted using a structured questionnaire sent experts in 25 European countries from January March 2012, requesting copy the guidelines. Responses were received 23 countries.Twenty-two (96%) supported policy recommend antenatal HIV screening for all pregnant women (15: opt-out strategy; 8: opt-in strategy). For HIV-positive whom only...
Abstract The objectives of this prospective multicentre international cohort study are to describe the characteristics a HIV‐1 positive women and determine best management system by comparing cervical pathology according results cytology, colposcopy human papillomavirus (HPV) testing at baseline throughout follow‐up. A. Cohorts known HIV‐positive were recruited from 6 hospital‐based European centres community‐based South African centre. Following registration, reviewed every months undergo...
The aim of the paper is to evaluate alcohol misuse among an inner city adult HIV clinic population with AUDIT (Alcohol Use Disorders Identification Test). A cross-sectional outpatient analysis between 28 February 2011 and 11 March was carried out. AUDIT, demographic clinical data were collected. Univariate performed look for associations variables. Backward stepwise multivariate analyses on significant variables from univariate assess predictors dependence. In total, 111 patients included...
We model Mode 2 direct discovery in Device-to- Device (D2D) Long Term Evolution (LTE) networks and derive the optimal value of message transmission probability that minimizes mean number periods required for a successful transmission. use Monte Carlo simulations to validate our analytical results show optimizing produces nearly performance with respect time all members group User Equipments (UEs) discover each other.
To investigate health-related quality of life in HIV-infected intravenous drug users registered but not engaged HIV outpatient care (missing ≥2 appointments over 1 year or non-attendance for ≥6 months) we conducted a cross-sectional study to examine at an inner city unit. EQ-5D, SF-36, SF-6D, mood disorder, clinical and substance misuse data were collected. Mean scores preference derived utility calculated. Statistical relationships between other variables explored using univariate...
Abstract Introduction Antiretroviral therapy (ART) is integral to HIV prevention, including averting vertical transmission. The World Health Organization (WHO) recommends ART and breastfeeding for all women living with at least 12 months post‐partum [1, 2]. Much of the data on transmission through comes from low‐resource settings, a paucity breastfeeding‐related in other settings. Women Against Viruses Europe (WAVE), part European AIDS Clinical Society (EACS), aims improve standard care...
Objectives To determine whether mutations conferring drug resistance are detectable after zidovudine monotherapy (ZDVm) in pregnancy, using both standard genotyping and more sensitive cloning assays. Methods Post‐delivery samples from women meeting the British HIV Association guidelines criteria for use of ZDVm prevention mother‐to‐child transmission (MTCT) who received were analysed Trugene HIV‐1 assay. In order to detect drug‐resistant minority species, a sub‐group 14 evaluated variants....
In the midst of COVID-19 pandemic, health care providers have had to rapidly change how they deliver patients. We discuss we are delivering a virtual HIV pre-exposure prophylaxis (PrEP) service during this time; challenges faced; expected and goals for coming months.
No cerebrospinal fluid (CSF) abnormalities are found in HIV-positive patients long-term follow-up after standard syphilis treatment. Syphilis has been reported to have immunological effects on HIV infection and is known modulate both the manifestations of serological response therapy. who had diagnosed with treated for prior 2007 were identified. Patients consented lumbar puncture. Serum viral load, CD4 count CSF recorded. Thirty-five previously underwent Thirty-four a normal neurological...
Injecting drug users (IDUs) represent 41.6% of the total cohort HIV-infected patients in Ireland. Between January 1999 and December 2000, referrals to largest tertiary centre for HIV infection Dublin have increased dramatically. This has occurred on a background reduction overall incidence Ireland between 1990 1998. Here we describe changing epidemiology disease IDUs explore potential aetiological factors.This is retrospective study, collecting all data relating new diagnoses occurring IDUs,...
We describe a case of aseptic meningitis following the administration moxifloxacin in 45-year-old man with human immunodeficiency virus (HIV). At presentation he was receiving tuberculosis treatment on modified regimen severe hepatotoxicity; this included moxifloxacin, started 8 days previously. Initial cerebrospinal fluid (CSF) analysis grossly abnormal. Anti-viral and -bacterial treatments were started. All microbiological tests proved negative his withheld resulting complete normalisation...