A5085686025- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Insurance, Mortality, Demography, Risk Management
- Autism Spectrum Disorder Research
- Mental Health Research Topics
- Neonatal and fetal brain pathology
- Cognitive Abilities and Testing
- Neural and Behavioral Psychology Studies
- Single-cell and spatial transcriptomics
- Neuroinflammation and Neurodegeneration Mechanisms
- Aging and Gerontology Research
- Genetic Associations and Epidemiology
- Neural dynamics and brain function
- Attention Deficit Hyperactivity Disorder
- Morphological variations and asymmetry
- Schizophrenia research and treatment
- Genetics and Neurodevelopmental Disorders
- Cognitive Science and Education Research
- Stress Responses and Cortisol
- Intensive Care Unit Cognitive Disorders
- EEG and Brain-Computer Interfaces
Hospital General Universitario Gregorio Marañón
2017-2022
Centro de Investigación Biomédica en Red de Salud Mental
2017-2022
Universidad Autónoma de Madrid
2020-2022
Neural oscillations are critical for brain function and cognition. Thus, identifying the typical or natural oscillatory frequencies of is an important first step understanding its functional architecture. Recently, a data-driven algorithm has been developed mapping brain′s throughout whole cortex, free anatomical frequency-band constraints. However, limitation this methodology that it yields robust results only at group level. Here, we aimed to adapt improve quality single-subject maps...
Abstract Schizophrenia is a biologically complex disorder with multiple regional deficits in cortical brain morphology. In addition, interindividual heterogeneity of morphological metrics larger patients schizophrenia when compared to healthy controls. Exploiting differences the severity instead focusing on group averages may aid detecting informed homogeneous subgroups. The person-based similarity index (PBSI) morphology indexes an individual’s morphometric across numerous regions amongst...
Sex differences in the development and aging of human sulcal morphology have been understudied. We charted sex trajectories inter-individual variability global depth, width, length, pial surface area, exposed (hull) gyral unexposed cortical thickness, span, cortex volume across lifespan a longitudinal sample (700 scans, 194 participants 2 104 three age range: 16-70 years) neurotypical males females. After adjusting for brain volume, females had thicker steeper thickness decline until 40...
Abstract Autism spectrum disorders (ASD) and early‐onset psychosis (EOP) are neurodevelopmental that share genetic, clinical cognitive facets; it is unclear if these also spatially overlapping cortical thickness (CT) surface area (SA) abnormalities. MRI scans of 30 ASD, 29 patients with first‐episode (EO‐FEP) 26 typically developing controls (TD) (age range 10–18 years) were analyzed by the FreeSurfer suite to calculate vertex‐wise estimates CT, SA, volume. Two publicly available datasets...
First-episode psychosis (FEP) patients show structural brain abnormalities at the first episode. Whether cortical changes that follow a FEP are progressive and whether age onset modulates these remains unclear. This is multicenter MRI study in deeply phenotyped sample of 74 with wide range (15-35 years) 64 neurotypical healthy controls (HC). All participants underwent two scans 2-year follow-up interval. We computed longitudinal percentage change (PC) for thickness (CT), surface area (CSA)...
Scaling between subcomponents of folding and total brain volume (TBV) in healthy individuals (HIs) is allometric. It unclear whether this true schizophrenia (SZ) or first-episode psychosis (FEP). This study confirmed normative allometric scaling norms HIs using discovery replication samples. Cross-sectional longitudinal diagnostic differences were then assessed an framework. Structural imaging from a (Sample 1: HI SZ, n Baseline = 298, SZ 169, Follow-up 293, 168, totaling 1087 images, all ≥...
Abstract Schizophrenia is a biologically complex disorder with multiple regional deficits in cortical brain morphology. In addition, interindividual heterogeneity of morphological metrics larger patients schizophrenia when compared to healthy controls. Exploiting differences severity instead focusing on group averages may aid detecting informed homogeneous subgroups. The Person-Based Similarity Index (PBSI) morphology indexes an individual’s morphometric similarity across numerous regions...
Background Early-onset first-episode psychosis (FEP) and high functioning autism spectrum disorders (ASD) are complex neuro–developmental that share symptomatology but it is not clear if they also neurobiological abnormalities (Chisholm et al., 2015). We examined thickness, surface area volume in a direct comparison of children adolescents with FEP (onset before 18 years), high-functioning ASD, healthy subjects. Methods Magnetic resonance imaging scans 85 participants (30 29 FEP, 26...
Abstract Background In a unique deeply phenotyped longitudinal dataset consisting of first-episode psychosis (FEP) patients with wide age at FEP onset (15 to 35 years) and healthy controls, we aimed determine whether cortical abnormalities are already present FEP, they progress further over the first two years illness, and, if so, change patterns associated episode. Methods Multicenter (four-site) two-year follow-up case-control brain magnetic resonance imaging study; 74 less than 12 months’...
Abstract Sex differences in development and aging of human sulcal morphology have been understudied. We charted sex trajectories inter-individual variability global depth, width, length, pial surface area, exposed (hull) gyral unexposed cortical thickness, cortex volume across the lifespan a longitudinal sample (700 scans, 194 participants two 104 three age range: 16-70 years) neurotypical males females. After adjusting for brain volume, females had thicker steeper thickness decline until 40...
ABSTRACT The archetypical folded shape of the human cortex has been a long-standing topic for neuroscientific research. Nevertheless, accurate neuroanatomical segmentation sulci remains challenge. Part problem is uncertainty where sulcus transitions into gyrus and vice versa. This can be avoided by focusing on sulcal fundi gyral crowns which represent topological opposites cortical folding. We present Automated Brain Lines Extraction (ABLE), method based Laplacian surface collapse to segment...
Abstract Scaling between subcomponents of cortical folding and total brain volume (TBV) in healthy individuals (HI) is allometric, i.e. non-linear. It unclear whether this also true with schizophrenia (SZ) or first-episode psychosis (FEP). The current study first confirmed normative allometric scaling norms HI using discovery replication samples. Cross-sectional longitudinal diagnostic differences were then assessed an analytic framework. Structural imaging from a (sample 1: SZ, n Baseline =...