A5079862709- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Genetic Associations and Epidemiology
- Cardiac electrophysiology and arrhythmias
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- RNA modifications and cancer
- Cryptography and Data Security
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Tracheal and airway disorders
- Security and Verification in Computing
- Sentiment Analysis and Opinion Mining
- Lung Cancer Diagnosis and Treatment
- Immune Cell Function and Interaction
- Spam and Phishing Detection
- RNA Research and Splicing
- Cloud Data Security Solutions
- Colorectal Cancer Treatments and Studies
- Epigenetics and DNA Methylation
- Image Enhancement Techniques
- Advanced Text Analysis Techniques
- Growth Hormone and Insulin-like Growth Factors
Zhejiang University
2019-2025
Xi'an Medical University
2020-2025
Huaian First People’s Hospital
2013-2024
Nanjing Medical University
2011-2024
Xuzhou Medical College
2019-2024
Second People’s Hospital of Huai’an
2019-2024
University of Chinese Academy of Sciences
2024
Fujian Institute of Research on the Structure of Matter
2024
Chinese Academy of Sciences
2024
Zhejiang Chinese Medical University
2024
Twitter sentiment analysis offers organizations an ability to monitor public feeling towards the products and events related them in real time. Most existing researches identify are focused on extraction of new features apply pre-processing before selection, although ignore role tweet pre-processing. In this paper, we discuss effects classification performance. We evaluated URL, stopword, repeated letters, negation, acronym number performance using two feature models four classifiers five...
Micro-blog services have become popular tools in the social networks. Online users discuss various topics micro-blog and some influential can affect opinions, attitudes, behaviors, or emotions of others. This paper proposes a user influence rank (UIRank) algorithm to identify through interaction information flow relationships among micro-blog. The UIRank considers contribution user's tweet characteristics dissemination networks calculates score iteratively by follower graph. Experimental...
Abstract Background This study investigates the relationship between triglyceride-glucose (TyG) index trajectories and results of ablation in patients with stage 3D atrial fibrillation (AF). Methods A retrospective cohort was carried out on who underwent AF Radiofrequency Catheter Ablation (RFCA) at Cardiology Department Fourth Affiliated Hospital Zhejiang University Taizhou Province from January 2016 to December 2022. The main clinical endpoint determined as occurrence arrhythmia for least...
Abstract Background Stroke is a common neurological disorder that disproportionately affects middle-aged and elderly individuals, leading to significant disability mortality. Recently, human blood metabolites have been discovered be useful in unraveling the underlying biological mechanisms of disorders. Therefore, we aimed evaluate causal relationship between susceptibility stroke. Methods Summary data from genome-wide association studies (GWASs) serum stroke its subtypes were obtained...
Abstract Background The association between night shift work and the risk of inflammatory bowel disease (IBD) remains unclear. We aim to investigate IBD, ulcerative colitis (UC), Crohn’s (CD), while further investigating roles genetic susceptibility circulating proteins. Methods This cohort study included 149,014 UK Biobank participants without IBD at baseline, with 28,772 undergoing proteomic detection. Cox regression assessed associations work, proteins, risk, multinomial logistic...
Non-small cell lung cancer (NSCLC) is the most common malignant tumor in world, of which prognosis generally poor due to insufficient mechanistic understanding. To explore molecular pathogenesis NSCLC, co-expression immunoglobulin-like transcript 4 (ILT4) and its ligand human leukocyte antigen G (HLA-G) NSCLC tissues cells were investigated. Here, we detected expression ILT4 HLA-G 81 specimens from primary patients, found that ILT4/HLA-G was significantly associated with regional lymph node...
Background: Although some observational studies have shown that physical activity may a positive relationship with cardiovascular diseases, the causal effect remains uncertain. We conducted Mendelian randomization (MR) study to identify potential between and diseases. Methods: Summary statistics of genome-wide association on four phenotypes diseases were utilized. MR analysis was performed using inverse-variance weighted (IVW) multivariable MR. Multiple sensitivity further robustness our...
Both short (<7 h per night) and long (≥9 sleep durations are related to atrial fibrillation (AF) heart failure (HF), but their causality has not been confirmed. We applied Mendelian randomization (MR) approaches estimate the causal association between genetically determined duration risk of AF HF. performed two-sample MR analysis obtain effect on Instrumental variables were constructed using genetic variants known be associated with continuous duration, duration. estimates HF derived...
Several observational studies have shown that cannabis use has negative effects on the cardiovascular system, but causality of this relationship not been confirmed. The aim current study was to estimate genetically determined risk diseases. Ten single-nucleotide polymorphisms related were employed as instruments association between and diseases using a two-sample Mendelian randomization (MR) method. Summary statistics data exposure outcomes obtained from different genome-wide meta-analysis...
Background: Detection of cervical high grade lesions in patients with atypical squamous cells undetermined significance (ASCUS) is still a challenge. Our study tested the efficacy paired boxed gene 1 (PAX1) methylation analysis by methylation-sensitive high-resolution melting (MS-HRM) detection ASCUS and compared performance hybrid capture 2 (HC2) human papillomavirus (HPV) test. Materials Methods: A total 463 consecutive women from primary screening were selected. Their scrapings collected...
Given the poor prognosis of metastatic esophageal squamous cell carcinoma (ESCC) patients, molecular mechanisms underlying progression and metastasis ESCC are highly desired in scientific community. Prostate cancer associated transcript-1 (PCAT-1) is a lncRNA up-regulated major types cancers with patients. This study aimed to understand expression role PCAT-1 identify potential lncRNA-miRNA interactions signaling pathways action ESCC.Gene levels were determined by qRT-PCR; protein Western...
<b><i>Purpose:</i></b> The purpose of this study is to examine the effectiveness introducing both rituximab (RTX) and <sup>131</sup>I for active Graves' ophthalmopathy (GO) with hyperthyroidism. <b><i>Methods:</i></b> In total, 217 patients suffering from GO hyperthyroidism were included in research. All subjects randomly assigned 3 groups. Patients group A solely received treatment; B1 underwent a methylprednisolone treatment...
Twitter sentiment analysis offers organizations an ability to monitor public feeling towards the products and events related them in real time. Most existing researches for are focused on extraction of feature lexical syntactic that expressed explicitly through words, emoticons, exclamation marks etc, although implicitly via latent contextual semantic relations, dependencies among words tweets ignored. In this paper, we introduce distributed representation sentence can capture co-occurrence...
Programmed death-1 (PD-1) polymorphisms have been associated with esophageal cancer risk.Here, the aims of this case-control study were to explore whether three PD-1 (rs10204525, rs7421861, and rs36084323) related risk clinical features in Chinese Han subjects (n = 814 cases 961 controls).We found that rs10204525 but not rs36084323, conferred increased susceptibility cancer.Subgroup analysis revealed all loci among men, rs7421861 correlated patients ≥ 60 years old.The higher TNM stage, was...
Abstract Prolonged pathological myocardial hypertrophy leads to end‐stage heart failure. Thymoquinone (TQ), a bioactive component extracted from Nigella sativa seeds, is extensively used in ethnomedicine treat broad spectrum of disorders. However, it remains unclear whether TQ protects the hypertrophy. This study was conducted examine potential utility for treatment cardiac and if so, elucidate underlying mechanisms. Male C57BL/6J mice underwent either transverse aortic constriction (TAC) or...
Background Recent research linked changes in the gut microbiota and serum metabolite concentrations to intracerebral hemorrhage (ICH). However, potential causal relationship remained unclear. Therefore, current study aims estimate effects of genetically predicted causality between microbiota, metabolites, ICH. Methods Summary data from genome-wide association studies (GWAS) ICH were obtained separately. Gut GWAS ( N = 18,340) acquired MiBioGen study, metabolites 7,824) TwinsUK KORA studies,...