Background Observational studies suggested that multiple sclerosis (MS) is associated with cardiovascular diseases (CVDs). However, the causal association has not been fully elucidated. Thus, we aim to assess causality of associations MS risk CVDs. Methods A two-sample Mendelian randomization (MR) study was performed explore causality. Genetic instruments were identified for from a genome-wide (GWAS) involving 115,803 individuals. Summary-level data CVDs obtained different GWAS meta-analysis...

OA is the most common form of arthritis worldwide and has a major impact on quality life among older population. This study aimed at determining potential causal effects several serum nutritional factors OA.A total seven were identified from genome-wide association studies. Summary statistics for obtained UK Biobank (194 153 women 166 988 men) large studies meta-analysis based European population (455 221, 393 873 403 124 overall, hip knee OA, respectively). Two-sample Mendelian...

Sex hormone-binding globulin (SHBG) has been reported to be a risk factor associated with the development of arthritis by previous observational studies more so three common forms arthritis: osteoarthritis (OA), rheumatoid (RA), and ankylosing spondylitis (AS). This study aimed determine whether concentrations circulating SHBG are causally OA, RA, AS.The two-sample Mendelian randomization (MR) approach was used for this study. The inverse-variance-weighted (IVW) method main analysis....

Abstract Purpose Multiple risk factors have been implicated in the development of osteoporosis. This study examined potential associations between serum nutritional and bone mineral density (BMD). Methods Six were selected as exposures. Outcomes included total body BMD (n = 66 945); at forearm (FA), femoral neck (FN) lumbar spine (LS) 8143, n 32 735, 28 498, respectively); estimated heel (HL eBMD) 394 929); HL eBMD stratified by sex 206 496). A 2-sample Mendelian randomization approach was...

Abstract Aims Observational studies indicate that serum urate level is associated with heart failure (HF). However, whether this association causal remains controversial, due to confounding factors and reverse causality. We aim evaluate the relationship of genetically predicted HF. Methods results A bidirectional Mendelian randomization (MR) study was performed. Instrumental variables were obtained from largest genome-wide (457 690 individuals) date. summary statistics HF HERMES consortium...

Both short (<7 h per night) and long (≥9 sleep durations are related to atrial fibrillation (AF) heart failure (HF), but their causality has not been confirmed. We applied Mendelian randomization (MR) approaches estimate the causal association between genetically determined duration risk of AF HF. performed two-sample MR analysis obtain effect on Instrumental variables were constructed using genetic variants known be associated with continuous duration, duration. estimates HF derived...

Metabolic traits are associated with the risk of developing glaucoma in observational studies. To assess whether theses associations reflect causality, we conducted a Mendelian randomization (MR) study. Our study included up to 20,906 cases and 438,188 controls. Genetic instruments concerned 11 exposures at genome-wide significance level were selected from corresponding association Summary-level data for obtained UK Biobank, GERA study, FinnGen consortium. Univariable multivariable MR...

Previous observational studies have shown an association between smoking and coronary artery disease (CAD) in patients with diabetes. Whether this reflects causality remains unestablished. This study aimed to explore the causal effect of on CAD diabetes.Genetic signatures for were extracted from a large genome-wide (GWAS), consisted up 1.2 million participants. Four phenotypes included: initiation, cigarettes per day, age at initiation regular smoking, cessation. Genetic associations...

Abstract Background We aimed to investigate the protein pathways linking obesity and lifestyle factors coronary artery disease (CAD). Methods Summary-level genome-wide association statistics of CAD were obtained from CARDIoGRAMplusC4D consortium (60,801 cases 123,504 controls) FinnGen study (R8, 39,036 303,463 controls). Proteome-wide Mendelian randomization (MR) analysis was conducted identify CAD-associated blood proteins, supplemented by colocalization minimize potential bias caused...

Numerous observational studies have suggested an association between psychiatric traits and carotid intima-media thickness (cIMT). However, whether these associations a causal relationship remains unknown, largely due to issues of reverse causality potential confounders. This study aims elucidate the role in risk arterial injury as measured by cIMT.

Abstract Purpose Accumulating evidence implicates parathyroid hormone (PTH) in the development of osteoporosis. However, causal effect PTH on bone mineral density (BMD) remains unclear. Thus, this study is aimed at exploring association between concentrations serum and BMD. Methods The instrumental variables for were selected from a large-scale genome-wide (GWAS; n = 29 155). Outcomes included BMD forearm (FA; 8143), femoral neck (FN; 33 297), lumbar spine (LS; 32 735), heel (HL; 394 929),...

Background Observational studies have indicated that psychosocial factors contribute to hypertension; however, the causality of these associations remains unclear due reverse and confounders. We aim assess causal mental health disorders with hypertension. Methods Instrumental variables anxiety disorder, attention deficit/hyperactivity autism spectrum depression, obsessive–compulsive post-traumatic stress schizophrenia, subjective well-being measure were obtained from corresponding largest...

Objective: To investigate the causal association of domain-specific sedentary behaviors with cerebrovascular diseases and neurodegenerative diseases, potential mediators among these associations. Methods: Genetic instruments were identified for television watching, computer use driving behavior from a genome-wide study including 408,815 subjects. Mendelian randomization (MR) analysis was used to estimate effect on diseases. Multivariable MR applied adjust confounding factors, mediation...

Background and aimsObservational studies have shown an association between mental health coronary artery disease (CAD) in patients with diabetes. Nevertheless, whether these associations are causal is still unknown. In this two-sample Mendelian randomization (MR) study, we aimed to assess the causality CAD diabetes.Methods resultsSingle-nucleotide polymorphisms (SNPs) associated with: depression (807,553 individuals), anxiety (83,556 individuals) neuroticism (329,821 were identified from...

Although iron homeostasis has been associated with liver function in many observational studies, the causality this relationship remains unclear. By using Mendelian Randomization analyses, we aimed to evaluate genetic effects of increased systemic levels on risk injury and various diseases. Moreover, light sex-dependent regulation human beings, further estimated sex-specific effect Independent single nucleotide polymorphisms status (including four indicators) at genome-wide significance...

Abstract Context Although the role of n-6 polyunsaturated fatty acids (PUFAs) in age-related macular degeneration (AMD) has been studied previous observational studies, precise manner which 1 or more PUFAs account for this relationship remains unclear. Objective Using genetic instruments traits implemented through mendelian randomization (MR), we aimed to study possible causal associations between and AMD. Methods The 2-sample MR method was used obtain unconfounded estimates. We selected...

Abstract Aims Observational studies have reported that homocysteine (Hcy) is associated with an increased risk of coronary artery disease (CAD) in individuals diabetes, though controversy remains. The present study aimed to investigate the causal association between Hcy and CAD diabetes. Methods A 2-sample Mendelian randomization (MR) was designed infer causality. Genetic summary data on single nucleotide polymorphisms (SNPs) were extracted from hitherto largest genome-wide (GWAS) up 44,147...

Cardiovascular diseases (CVDs) are a major global health concern, highlighting the need for effective diagnostic tools. Zinc ions (Zn2+) play role in CVDs, but their detection is challenging. This study presents multifunctional optical sensor, HD-Zn, designed to detect Zn2+ relation CVDs. We developed novel fluorescence probe, by conjugating N,N-di(2-picolyl)ethylenediamine (DPEN) HD via an amide bond, which results quenching due photoinduced electron transfer (PeT). Adding significantly...

Iron overload has been implicated in the pathogenesis of varicose veins (VVs). However, association serum iron status with other vascular diseases (VDs) is not well understood, which might be a potential target for VD prevention. This study was aimed at investigating causal associations between and VDs using Mendelian randomization (MR) method.A two-sample MR designed to investigate whether associated VDs, based on data from published genome-wide meta-analysis 48,972 subjects European...