Abstract Background Quercetin derivatives in onions have been regarded as the most important flavonoids to improve diabetic status cells and animal models. The present study was aimed examine hypoglycemic insulin-sensitizing capacity of onion peel extract (OPE) containing high quercetin fat diet/streptozotocin-induced rats elucidate mechanism its effect. Methods Male Sprague-Dawley were fed AIN-93G diet modified contain 41.2% intraperitoneally injected with a single dose streptozotocin (40...

High level of serum cholesterol is considered to be a major risk factor for cardiovascular disease (CVD). A double-blinded, randomized, placebo-controlled trial was performed test the hypothesis that daily intake Chlorella may improve lipid profile through enhancement carotenoid concentration in mildly hypercholesterolemic subjects.Eligible subjects (n = 63) were randomized either (5 g/day) or placebo double-blinded with 2-week lead-in period and 4-week intervention period. Serum...

Non-alcoholic fatty liver disease (NAFLD) is the most prevalent cause of chronic hepatic injury in world. One important therapeutic strategies for this modulating oxidative stress. This study hypothesized that supplementation pinitol might exert protective effects, by stress subjects with NAFLD. A randomized, double-blind controlled trial was conducted 90 ultrasonography-proven NAFLD, who were randomly assigned to placebo, low-dose (300 mg/d), or high-dose (500 mg/d) 12 weeks. The outcome...

It is important to understand the association between oxidative stress‐related parameters and evaluate their status in advance of chronic disease development. Further development towards can then be prevented by dietary antioxidants. The present study was aimed at assessing relationship diet quality, blood antioxidants, damage determine whether these markers differs stress status. For a cross‐sectional analysis, we used data samples baseline information from prospective cohort study. A total...

Previous animal studies suggested that Chlorella, a unicellular green alga, has preventive role in maintaining serum cholesterol levels against excess dietary intake. This study aimed to conduct pioneering investigation clarify this issue healthy subjects by adopting challenge, which not been used previously similar of Chlorella hypercholesterolemia. In double blind, randomized, placebo-controlled study, 34 participants ingested 510 mg from three eggs concomitantly with usual dose (5 g/d) or...

Reactive oxygen species are important risk factors for age-related diseases, but they also act as signaling endogenous antioxidative defense. The hypothesis that a multi-micronutrient supplement with nutritional doses of antioxidant nutrients and phytochemicals (MP) may provide protection against oxidative damage maintain the defense capacity was assessed in subjects habitually low intake fruits vegetables. In randomized, placebo-controlled, parallel designed trial, 89 eligible were assigned...

Phytonutrients and vitamin mineral supplementation have been reported to provide increased antioxidant capacity in humans; however, there is still controversy. In the current clinical trial, we examined DNA protection of a plant-based, multi-vitamin/mineral, phytonutrient (PMP) healthy adults who were habitually low consumption fruits vegetables. This study was an eight-week, double-blind, randomized, parallel-arm, placebo-controlled trial. PMP for eight weeks reduced reactive oxygen species...

The vascular endothelium is a favorite early target of cardiovascular risk factors, including cigarette smoking. Here, we investigated the synergistic effects Sanghuang⁻Danshen (SD) bioactives on stiffness in controlled clinical trial healthy chronic smokers (n = 72). Relative to placebo, 4-week SD consumption at 900 mg/day improves pulse wave velocity (p 0.0497), reduces systolic blood pressure (peripheral, p 0.0008; brachial, 0.0046; and ankle, 0.0066), increases endothelial nitric oxide...

Soybeans and hops have been traditionally used as a natural estrogen replacement therapy their major active ingredients, isoflavones prenylflavanones, are known to estrogenic/antiestrogenic effects depending on the target organ. However, potential benefits still subject controversies. The present study investigated dual effect of soy plus hop prenylflavanones (Soy-Hop) bone loss metabolic dysfunction under deficient condition. Rats were sham-operated (n = 10) or ovariectomized (OVX; n 40)...

Arterial stiffness and endothelial dysfunction are 2 of the independent predictors for cardiovascular disease, while Acanthopanax senticosus Harms (ASH) is a traditional medicinal plant that can improve health. This study aimed to investigate efficacy fruit ASH on vascular function in apparently healthy subjects.A 12-week, randomized, double-blind, placebo-controlled design, consisting adults with at least following 3 conditions: borderline high blood pressure (BP; 120 mmHg ≤ systolic BP 160...

본 연구에서는 2013 ~ 2016년 국민건강영양조사 자료를 이용하여 19 64세 성인 남녀의 커피 섭취 종류와 섭취량(정량적 식품섭취빈도조사 자료 활용)에 따른 일반사항, 총 당류를 포함한 영양섭취상태, 건강관련 삶의 질 및 대사증후군과의 관련성을 분석하였다. 남성과 여성 모두에서, 에너지 섭취량이 에너지필요추정량 (EER) 미만인 사람과 철분 평균필요량 (EAR) 사람의 비율이 3-in-1 섭취군에서 낮았다. 커피를 섭취하지 않는 여성과 비교했을 때, 하루 2회 이하로 섭취하는 여성은 EQ-5D를 통해 조사한 건강 관련 질저하에 대한 위험이 19% 낮은 것으로 나타났으며, 모두에서 섭취하고 있는 커피의 섭취량에 따라 대사증후군 지표 대사증후군에 위험에 차이가 없었다. 따라서 섭취가 위험과 관련이 있었으나, 지표에 위험과는 없다는 결론을 얻을 수 있었다. 앞으로 나아가 사망률까지 이어지는 건강에 미치는 영향에 기전을 파악하기 위해 이와 관련하여 잘 설계된 무작위...

This study investigated the effect of microencapsulated garlic and/or tomato on endothelial dysfunction induced by PhenFlex test (PFT) in healthy male smokers.

Elevation of postprandial lipemia characterized by a rise in triglyceride (TG)-rich lipoproteins can increase the risk atherogenesis. The objective this study was to investigate response single dietary fat/sugar load test and monitor beneficial changes induced consumption Platycodi radix (AP) beverage healthy subjects.A total 52 subjects were randomly assigned either placebo or AP group with high-fat shake randomized controlled crossover trial. Postprandial blood collected at 0, 1, 2, 4, 6 h...

With the increased risk of cardiovascular disease, use botanicals for vascular endothelial dysfunction has intensified. Here, we explored synergistic mechanisms Sanghuang-Danshen (SD) phytochemicals on homeostatic protection against high-fat-induced in healthy subjects, using a network biology approach, based randomised crossover clinical trial. Seventeen differential markers identified blood samples taken at 0, 3 and 6 h post-treatment, together with 12SD phytochemicals, were mapped onto...

Red ginseng has been widely used in health-promoting supplements Asia and is becoming increasingly popular Western countries. However, its therapeutic mechanisms against most diseases have not clearly elucidated. The aim of the present study was to provide biological red various metabolic diseases. We a systems approach comprehensively identify component-target target-pathway networks order explore underlying potential Of 23 components with target, 5 were linked 37 target molecules....

Cross-over designs have been widely used in clinical trials to investigate the efficacy of new treatments. In cross-over design, each subject is treated subsequently with different Many methods such as linear mixed models (LMMs) and generalized estimating equation (GEE) analyze repeated measurements from design. When we consider measured response variables, estimation random components for LMMs not always easy. this article, applied GEE method design overcome limitation LMMs. To apply model...