A5048100952- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Cervical Cancer and HPV Research
- Viral-associated cancers and disorders
- Immunotherapy and Immune Responses
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- CAR-T cell therapy research
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Water Treatment and Disinfection
- Cancer Mechanisms and Therapy
- Transplantation: Methods and Outcomes
- Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Organ Transplantation Techniques and Outcomes
- Systemic Lupus Erythematosus Research
- Chromatin Remodeling and Cancer
- RNA Interference and Gene Delivery
- Lymphoma Diagnosis and Treatment
- Galectins and Cancer Biology
- Antimicrobial Peptides and Activities
Tianjin University
2025
The First Affiliated Hospital, Sun Yat-sen University
2020-2024
Zhongshan Hospital
2020-2024
Fudan University
2018-2024
Sun Yat-sen University
2020-2024
Shanghai Jiao Tong University
2022-2024
Shanghai Sixth People's Hospital
2023-2024
Shaanxi Provincial People's Hospital
2024
Shanxi Medical University
2024
Renji Hospital
2024
Emerging immune therapy, such as with the anti–programmed cell death–1 (anti–PD-1) monoclonal antibody nivolumab, has shown efficacy in tumor suppression. Patients terminal cancer suffer from pain a result of bone metastasis and destruction, but how PD-1 blockade affects remains unknown. Here, we report that mice lacking Pdcd1 (Pd1−/−) demonstrated remarkable protection against destruction induced by femoral inoculation Lewis lung cells. Compared WT mice, Pd1−/− exhibited increased baseline...
Objective: To investigate the clinical significance of IL-10 + tumor-associated macrophages (TAMs) in gastric cancer. Background: Due to plasticity and diversity TAMs, it is necessary phenotypically functionally classify subsets TAMs better understand critical role cancer progression. expressing interleukin-10 (IL-10) have been found facilitate immune evasion many malignancies, but remains obscure. Methods: Four hundred sixty-eight tumor tissue microarray specimens, 52 fresh samples patients...
Abstract Studies that examined an association between CD8 + T and prognosis in gastric cancer are inconsistent, a distinct population of CXCR5 associated with better overall survival has been reported among various malignancies. Here, we show the abundance intratumoral cells is patients cancer. Patients TNM II III higher cell infiltration more likely to benefit from adjuvant chemotherapy. Microsatellite-unstable Epstein–Barr virus positive tumors enriched cells. Gastric infiltrating...
Abstract Background and aims In gastric cancer, the response rate of programmed cell death protein‐1 (PD‐1) inhibitor is far from satisfactory, indicating additional nonredundant pathways might hamper antitumour immunity. V‐domain immunoglobulin suppressor T‐cell activation (VISTA) has been reported in several malignancies as a novel immune‐checkpoint. Nevertheless, role VISTA cancer still remains obscure. Our purpose to explore clinical significance potential mechanism affecting patients’...
Abstract Objective To estimate the relative risk of incident cancer diagnosis among patients with juvenile idiopathic arthritis (JIA) compared to without JIA. Methods A cohort biologics‐naive diagnosed JIA between 1998 and 2007 a matched comparators were assembled from PharMetrics Patient‐Centric Database. The primary outcome was any malignancy, excluding nonmelanoma skin carcinoma in situ. Claims profiles cancer‐related codes reviewed determine outcomes. Incidence rates 95% confidence...
Abstract Background Although PD-1 has been reported to be a marker of T-cell exhaustion in several malignancies, the biological role + CD8 T cells gastric cancer (GC) remains unclear. Herein, we aimed investigate tumour microenvironment and its clinical significance GC. Designs This study included 441 microarray specimens 60 Flow cytometry GC patients from Zhongshan Hospital, 250 Asian Cancer Research Group . Results Here, demonstrated that functioned as an independent adverse prognosticator...
Abstract In gastric cancer (GC), the therapeutic response of immune checkpoint blockade (ICB) remains suboptimal. Targeting myeloid cell checkpoints might be feasible as adjuvant to current ICB regimens. We sought evaluate crucial role C5aR1 + TAMs in regulating antitumor immunity and efficacy combinatorial treatment with antiprogrammed death protein‐1 (PD‐1) blockade. Here, we found that was predominantly expressed on macrophages high level infiltration could predict poor prognosis inferior...
This study aimed to reveal the effect of TP53 status on clinical outcomes and underlying mechanism in gastric cancer (GC) patients.
As an adverse survival prognosticator, chemokine (C-X-C motif) ligand 13 (CXCL13) has been studied in several types of malignancies. The secretion and physiological roles CXCL13 follicular helper T cells (TFH) have well described, while the clinical significance CD8+ tumor-infiltrating lymphocytes (TILs)-associated remains unknown. This study aims to investigate CXCL13+CD8+ chemotherapeutic responsiveness prediction gastric cancer. In this study, 440 patients enrolled from Zhongshan Hospital...
AT-rich interaction domain 1A (ARID1A) encodes a vital component of switch/sucrose non-fermentable chromatin-remodeling complex. Given its association with genomic instability, we conducted this study to determine whether ARID1A mutation status had an impact on therapeutic responsiveness in gastric cancer (GC), especially combinatory chemo-immunotherapy.We retrospectively enrolled total 1162 patients from five independent cohorts. ZSHS Cohort and TCGA were designed inform chemotherapeutic...
Background With the essential role of interleukin-1 signaling in cancer-related inflammation, IL-1R1, main receptor for both IL-1α and IL-1β, demonstrated therapeutic potential several types cancer, which has been put into clinical trials. However, expression profile critical IL-1R1 gastric cancer (GC) remain obscure. This study aimed to investigate prognostic significance its predictive value chemotherapy immunotherapy GC. Methods The enrolled three cohorts, consisting 409 tumor microarray...
This study aimed to investigate the expression and clinical significance of Dendritic cell-associated C-type lectin-1 (Dectin-1) in gastric cancer (GC), explore mechanism Dectin-1 regulating tumour-associated macrophage (TAM)-mediated immune evasion GC.The association Dectin-1+ cells with outcomes was inspected by immunohistochemistry on tumour microarrays. Flow cytometry RNA sequencing were applied detect characteristics T cells, phenotypic transcriptional features TAMs. The effect blockade...
Apolipoprotein B mRNA editing enzyme catalytic polypeptide 3B (APOBEC3B) plays an important role in tumor mutagenesis. However, its clinical significance gastric cancer (GC) remains largely unknown. We enrolled a total of 482 GC patients from Zhongshan Hospital, Fudan University for immunohistochemistry (IHC) staining to evaluate the prognostic and predictive values APOBEC3B. Genomic phenotypic datasets Cancer Genome Atlas (TCGA) Asian Research Group (ACRG) cohort were downloaded external...
Bronchoscopy is a key step in the diagnosis and treatment of respiratory diseases. However, level expertise varies among different bronchoscopists. Artificial intelligence (AI) may help them identify bronchial lumens. Thus, bronchoscopy quality-control system based on AI was built to improve performance bronchoscopists.This single-center observational study consecutively collected videos from Shanghai Chest Hospital segmented each video into 31 anatomical locations develop an AI-assisted...
Objective Immunotherapy has not yielded satisfactory therapeutic responses in gastric cancer (GC). However, targeting myeloid checkpoints holds promise for expanding the potential of immunotherapy. This study aims to evaluate critical role Siglec-10 + tumor-associated macrophages (TAMs) regulating antitumor immunity and explore checkpoint as an interventional target. Design TAMs were assessed based on immunohistochemistry tumor microarrays RNA-sequencing data. Flow cytometry, RNA sequencing,...
Abstract Lymphocyte activation gene 3 (LAG‐3) is a transmembrane immune checkpoint that facilitates escape via suppressing T‐cell‐mediated anti‐tumor immunity. The role of LAG‐3 in gastric cancer little known. Consequently, we assessed the clinical significance cancer. In our study, patients with from Zhongshan Hospital ( n = 464) and data Asian Cancer Research Group 300) were analyzed. + cell infiltration other contexture detected by immunohistochemistry. Kaplan‐Meier curves log‐rank test...