A5014381301- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- Immune Cell Function and Interaction
- Inflammatory Bowel Disease
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Asthma and respiratory diseases
- Galectins and Cancer Biology
- Glycosylation and Glycoproteins Research
- Microscopic Colitis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cytokine Signaling Pathways and Interactions
- IL-33, ST2, and ILC Pathways
- Pediatric health and respiratory diseases
- Immune Response and Inflammation
- Nanoparticle-Based Drug Delivery
- Exercise and Physiological Responses
- Allergic Rhinitis and Sensitization
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- NF-κB Signaling Pathways
- Helicobacter pylori-related gastroenterology studies
- Dermatology and Skin Diseases
- Chemokine receptors and signaling
- Heat shock proteins research
AstraZeneca (Finland)
2025
AstraZeneca (Sweden)
2018-2024
Karolinska Institutet
2010-2021
Institut Curie
2015-2019
Inserm
2015-2019
Université Paris Sciences et Lettres
2017
Immunité et Cancer
2017
Friedrich Schiller University Jena
2016
Jena University Hospital
2016
Karolinska University Hospital
2009-2013
Activation of the cyclic dinucleotide sensor stimulator interferon (IFN) genes (STING) is critical for IFN and inflammatory gene expression during innate immune responses. However, role STING in adaptive immunity still unknown. In this study, we show that activation reduces proliferation T lymphocytes. This activity was independent TBK1 IRF3 recruitment type I but required a distinct C-terminal domain activates NF-κB. Inhibition cell by its relocalization to Golgi apparatus caused mitotic...
Abstract Exosomes are secreted membrane nanovesicles of endosomal origin and considered potential cancer vaccine vectors. Phase I clinical trials have been successfully conducted with tumor peptide–loaded exosomes derived from dendritic cells (dexosomes), a phase II trial is ongoing. However, much still unknown regarding the in vivo role dexosomes whether their immunogenicity can be enhanced. We previously reported that induce CD4+ T cell responses B cell–dependent manner, suggesting...
Background Intercellular communication can occur via the release of membrane vesicles. Exosomes are nanovesicles released from endosomal compartment cells. Depending on their cell origin and cargo they exert different immunoregulatory functions. Recently, fungi were found to produce extracellular vesicles that influence host-microbe interactions. The yeast Malassezia sympodialis which belongs our normal cutaneous microbial flora elicits specific IgE- T-cell reactivity in approximately 50%...
Abstract Exosomes and the invariant NKT (iNKT) immune cell ligand α-galactosylceramide (αGC) may offer novel tools for cancer immunotherapy. In this study, we investigated whether exosomes loaded with αGC can activate iNKT cells potentiate a cancer-specific adaptive response. readily activated both in vitro vivo. plus model antigen ovalbumin (OVA) induced potent NK γδ T-cell innate responses, they also synergistically amplified T- B-cell responses that were OVA specific. contrast to soluble...
Malassezia sympodialis is a dominant commensal fungi in the human skin mycobiome but also associated with common disorders including atopic eczema (AE). M. releases extracellular vesicles, designated MalaEx, which are carriers of small RNAs and allergens, they can induce inflammatory cytokine responses. Here we explored how MalaEx involved host-microbe interactions by comparing protein content that parental yeast cells, investigating cells skin. Cryo-electron tomography revealed...
Rationale: Emerging evidence supports a crucial role for tertiary lymphoid organs (TLOs) in chronic obstructive pulmonary disease (COPD) progression. However, mechanisms of immune cell activation leading to TLOs COPD remain be defined.Objectives: To examine the lung dendritic cells (DCs) T follicular helper (Tfh)-cell induction, T-cell subset critically implicated organ formation, COPD.Methods: Myeloid heterogeneity and phenotype were studied an unbiased manner via single-cell RNA sequencing...
Abstract Background Crohn’s Disease (CD) is a chronic condition that can impact any part of the gastrointestinal tract. The sustained inflammation driven by continuous influx inflammatory leukocytes into gut mucosa, which regulated through chemokine gradients and adhesion molecules, including integrins. In gut, migration cells to specific segments thought be mediated selected integrins and/or axes. CCL25/CCR9 axis has been identified as key pathway for immune cell small bowel segments, such...
Naive CD4+ T lymphocytes differentiate into different effector types, including helper and regulatory cells (Th Treg, respectively). Heritable gene expression programs that define these types are established during differentiation, but little is known about the epigenetic mechanisms install maintain programs. Here, we use mice defective for components of heterochromatin-dependent silencing to investigate control cell plasticity. We show that, upon receptor (TCR) engagement, naive TRIM28 (an...
The paracaspase mucosa-associated lymphoid tissue lymphoma translocation protein-1 (MALT1) regulates nuclear-factor-kappa-B (NF-κB) activation downstream of surface receptors with immunoreceptor tyrosine-based motifs (ITAMs), such as the B-cell or T-cell receptor and has thus emerged a therapeutic target for autoimmune diseases. However, recent reports demonstrate development lethal inflammation due to excessive production interferon gamma (IFN-ɣ) defective differentiation regulatory T-cells...
Cysteinyl leukotrienes (cysLTs) are potent proinflammatory mediators with particular relevance for asthma. However, control of cysLT biosynthesis in the time period after onset acute inflammation has not been extensively studied. As a model later phases inflammation, we investigated regulation leukotriene (LT) C4 synthase (LTC4S) differentiating monocytes, exposed several days to fungal zymosan. Incubations LTA4 revealed 20-fold increased LTC4S activity during differentiation monocytic Mono...
Exosomes derived from dendritic cells (dexosomes) induce potent antitumor immune responses in mice. We have shown that the efficacy of dexosome-elicited immunity relies on presence both T- and B-cell dexosome-associated epitopes. Hence, inclusion epitopes anticancer vaccines is crucial for success this immunotherapeutic intervention.
Abstract Regulatory T cells (Tregs) are the key regulating peripheral autoreactive lymphocytes. Tregs exert their function by suppressing effector cells. have been shown to play essential roles in control of a variety physiological and pathological immune responses. However, unstable can lose expression FOXP3 suppressive functions as consequence outer stimuli. Available literature suggests that secreted proteins regulate Treg functional states, such differentiation, proliferation function....
Iron is a key element for systemic oxygen delivery and cellular energy metabolism. Thus regulation of local iron metabolism maintaining homeostasis. Significant changes in levels due to malnutrition or hemorrhage, have been associated with several diseases such as hemochromatosis, liver cirrhosis COPD. Macrophages are cells regulating tissues they sequester excess iron. How overload affects macrophage differentiation function remains subject debate. Here we used an vitro model...
Abstract Background Interleukin23 (IL-23) is a cytokine that plays crucial role in the pathogenesis of inflammatory bowel disease (IBD), making it highly validated therapeutic target. Understanding IL-23 IBD at histopathological level for determining effective treatment strategies, providing insights into patients who fail to respond targeted therapies, or predicting those are likely lose response. In this context, there surge utilizing artificial intelligence (AI) data and other...
Oxidative stress in the human lung is caused by both internal (e.g., inflammation) and external stressors (smoking, pollution, infection) to drive pathology a number of diseases. Cellular damage oxidative reversed several pathways, one which antioxidant response. This response regulated transcriptional factor NRF2, has ability regulate transcription more than 250 genes. In disease, this balance overwhelmed, cells are unable return homeostasis. Several pharmacological approaches aim improve...
Anticancer immunotherapy is a promising treatment modality since it bears the potential of being highly specific, but effective clinical applications are still under development. We have recently described an exosome-based strategy for co-delivery α-galactosylceramide and tumor-associated antigen that synergistically potentiates tumor-specific adaptive immune responses while preventing anergy invariant natural killer T (iNKT) cells. propose next generation immunotherapies should involve...
Regulatory T (Treg) cells, expressing the transcription factor forkhead box p3 (FOXP3), are key cells regulating peripheral autoreactive lymphocytes by suppressing effector cells. FOXP3+ Treg play essential roles controlling immune responses in autoimmune diseases and cancer. Several clinical approaches (e.g., polyclonal expansion of with anti-CD3 anti-CD28 coated beads presence drugs) under evaluation. However, expression FOXP3, recognized as master regulator induced have been shown to be...
<b>Background:</b> Clinical trials are designed to investigate innovative diagnostic and therapeutic strategies for patients. However, factors that influence patients with inflammatory bowel disease (IBD) willingness participate in a clinical trial unknown. <b>Methods:</b> We developed questionnaire asked IBD about their hypothetically current health-related quality of life by using the IBDQ. <b>Results:</b> Of 201 distributed questionnaires, 166 were returned included analysis....