A5007094531- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Insect symbiosis and bacterial influences
- Mosquito-borne diseases and control
- COVID-19 Clinical Research Studies
- Viral Infections and Outbreaks Research
- Viral Infections and Vectors
- Heparin-Induced Thrombocytopenia and Thrombosis
- Virus-based gene therapy research
The Pirbright Institute
2020-2022
SARS-CoV-2 variants may threaten the effectiveness of vaccines and antivirals to mitigate serious COVID-19 disease. This is most concern in clinically vulnerable groups such as older adults. We analysed 72 sera samples from 37 individuals, aged 70-89 years, vaccinated with two doses BNT162b2 (Pfizer-BioNTech) 3 weeks apart, for neutralizing antibody responses wildtype SARS-CoV-2. Between 20 after second vaccine dose, titres fell 4.9-fold a median titre 21.3 (neutralization dose 80%), 21.6%...
SARS-CoV-2 has a broad mammalian species tropism infecting humans, cats, dogs, and farmed mink. Since the start of 2019 pandemic, several reverse zoonotic outbreaks have occurred in mink, one which reinfected humans caused cluster infections Denmark. Here we investigate molecular basis mink ferret adaptation demonstrate spike mutations Y453F, F486L, N501T all specifically adapt to use mustelid ACE2. Furthermore, risk assess these conclude mink-adapted viruses are unlikely pose an increased...
Abstract RaTG13 is a close relative of SARS-CoV-2, the virus responsible for COVID-19 pandemic, sharing 96% sequence similarity at genome-wide level. The spike receptor binding domain (RBD) contains number amino acid substitutions when compared to likely impacting affinity ACE2 receptor. Antigenic differences between viruses are less well understood, especially whether can be efficiently neutralised by antibodies generated from infection with, or vaccination against, SARS-CoV-2. Using and...
Abstract SARS-CoV-2 has a broad mammalian species tropism infecting humans, cats, dogs and farmed mink. Since the start of 2019 pandemic several reverse zoonotic outbreaks have occurred in mink, one which reinfected humans caused cluster infections Denmark. Here we investigate molecular basis mink ferret adaptation demonstrate spike mutations Y453F, F486L, N501T all specifically adapt to use mustelid ACE2. Furthermore, risk assess these conclude mink-adapted viruses are unlikely pose an...
Abstract SARS-CoV-2 has a broad mammalian species tropism infecting humans, cats, dogs and farmed mink. Since the start of 2019 pandemic several reverse zoonotic outbreaks have occurred in mink, one which reinfected humans caused cluster infections Denmark. Here we investigate molecular basis mink ferret adaptation demonstrate spike mutations Y453F, F486L, N501T all specifically adapt to use mustelid ACE2. Furthermore, risk assess these conclude mink-adapted viruses are unlikely pose an...
Abstract RaTG13 is a close relative of SARS-CoV-2, the virus responsible for Coronavirus Disease 2019 (COVID-19) pandemic, sharing 96% sequence similarity at genome-wide level. The spike receptor binding domain (RBD) contains large number amino acid substitutions when compared to likely impacting affinity ACE2 receptor. Antigenic differences between viruses are less well understood, especially whether can be efficiently neutralised by antibodies generated from infection with, or vaccination...