A5103238983- Diet and metabolism studies
- Dietary Effects on Health
- Lipid metabolism and disorders
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Diet, Metabolism, and Disease
- Cardiac Valve Diseases and Treatments
- Ovarian function and disorders
- Gut microbiota and health
- Mechanical Circulatory Support Devices
- Reproductive System and Pregnancy
- Fatty Acid Research and Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Cardiac and Coronary Surgery Techniques
University of Copenhagen
2016-2023
Eastern Maine Medical Center
2007
Women with polycystic ovary syndrome (PCOS) often change their metabolic profile over time to decrease levels of androgens while gaining a propensity for the development syndrome. Recent discoveries indicate that microRNAs (miRNAs) play role in PCOS and constitute potential biomarkers PCOS. We aimed identify miRNAs associated an impaired women PCOS, follow-up study, compared without PCOS.Clinical measurements status disease were obtained twice 6 years apart cohort 46 nine controls. All...
Objective This study investigated whether the levels of specific serum microRNAs (miRNAs) were altered following diet‐induced weight loss and miRNAs differed in presence metabolic syndrome. Methods The was a intervention trial with prescribed energy deficit approximately 500 kcal/d. Levels 22 determined samples from 85 participants overweight or obesity. analyzed using TaqMan Array miRNA Cards normalized to geometric mean spiked‐in ath‐miR‐159a U6 small nuclear RNA ΔC T method. Results...
Scope Dietary‐based strategies are regularly explored in controlled clinical trials to provide cost‐effective therapies tackle obesity and its comorbidities. The article presents a complementary analysis based on multivariate multi‐omics approach of caloric restriction intervention (CRD) with fiber supplementation unveil synergic effects body weight control, lipid metabolism, gut microbiota. Methods results study explores fecal bile acids (BAs) short‐chain fatty (SCFAs), plasma BAs, shotgun...
Angiopoietin-like protein 4 (ANGPTL4) is a lipoprotein lipase inhibitor that involved in lipid metabolism and angiogenesis. Animal studies have suggested the ANGPTL4 modulated by gut microbiota, possibly through increased concentrations of SCFA, such as C4, found whole-fat milk or result fermentation inulin. This study investigated whether standardised diet either high fat content supplemented with inulin powder would increase plasma overweight men this was mediated compositional change...
Angiopoietin-like protein 3 (ANGPTL3), a liver-derived protein, plays an important role in the lipid and lipoprotein metabolism. Using data available from DiOGenes study, we assessed link with clinical improvements (weight, plasma lipid, insulin levels) changes liver markers, alanine aminotransferase, aspartate aminotransferase (AST), adiponectin, fetuin A B, cytokeratin 18 (CK-18), upon low-calorie diet (LCD) intervention. We also examined of genetic variation determining level circulating...
Scope Brown and brite adipocytes within the mammalian adipose organ provide non‐shivering thermogenesis thus, have an exceptional capacity to dissipate chemical energy as heat. Polyunsaturated fatty acids (PUFA) of n3‐series, abundant in fish oil, been repeatedly demonstrated enhance recruitment thermogenic these cells, consequently affecting body adiposity glucose tolerance. These effects are scrutinized mice housed a thermoneutral environment human dietary intervention trial. Methods...