A5064859160- Insect-Plant Interactions and Control
- Lepidoptera: Biology and Taxonomy
- Insect Resistance and Genetics
- CRISPR and Genetic Engineering
- Forest Insect Ecology and Management
- Genetic Syndromes and Imprinting
- Pluripotent Stem Cells Research
- Agronomic Practices and Intercropping Systems
- Bat Biology and Ecology Studies
- Genomics and Chromatin Dynamics
- Bioinformatics and Genomic Networks
- Microbial Metabolic Engineering and Bioproduction
- Pain Mechanisms and Treatments
- Olfactory and Sensory Function Studies
- Entomological Studies and Ecology
- Neurotransmitter Receptor Influence on Behavior
- Marine Ecology and Invasive Species
- Marine Bivalve and Aquaculture Studies
- Insect symbiosis and bacterial influences
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Genetics, Aging, and Longevity in Model Organisms
- Plant nutrient uptake and metabolism
- Neuroscience and Neuropharmacology Research
- Animal Behavior and Reproduction
- Genetic Mapping and Diversity in Plants and Animals
Inserm
2015-2022
Université de Montpellier
2015-2022
Centre National de la Recherche Scientifique
2010-2022
Institut de Génomique Fonctionnelle
2015-2022
Montpellier GenomiX
2016-2022
Université Paris-Sud
2010
Laboratoire de Recherche en Informatique
2010
Modélisation et Ingénierie des Systèmes Complexes Biologiques pour le Diagnostic
2010
We recently reported the identification and characterization of DNA replication origins (Oris) in metazoan cell lines. Here, we describe additional bioinformatic analyses showing that previously identified GC-rich sequence elements form origin G-rich repeated (OGREs) are present 67% to 90% from Drosophila human cells, respectively. Our also show initiation synthesis takes place precisely at 160 bp (Drosophila) 280 (mouse) OGRE. found most CpG islands, an OGRE is positioned opposite...
Abstract Action control is a key brain function determining the survival of animals in their environment. In mammals, neurons expressing dopamine D2 receptors (D2R) dorsal striatum (DS) and nucleus accumbens (Acb) jointly but differentially contribute to fine regulation movement. However, region-specific molecular features are presently unknown. By combining RNAseq striatal D2R histological analyses, we identified hundreds novel markers, which may serve as tools target selective...
Cutaneous C-unmyelinated MRGPRD+ free nerve endings and C-LTMRs innervating hair follicles convey two opposite aspects of touch sensation: a sensation pain pleasant touch. The molecular mechanisms underlying these diametrically functions are unknown. Here, we used mouse model that genetically marks neurons in combination with fluorescent cell surface labeling, flow cytometry, RNA deep-sequencing technology (RNA-seq). Cluster analysis RNA-seq profiles the purified neuronal subsets revealed...
Most phytophagous insects have morphological, behavioral and physiological adaptations allowing them to specialize on one or a few plant species. Identifying the mechanisms involved in host specialization is crucial understand role of divergent selection between different environments species diversification, identify sustainable targets for management insect pest In present study, we measured larval phenotypic transcriptomic responses plants two related lepidopteran species: European corn...
Abstract Nod factors (NF) were assumed to be indispensable for the establishment of a rhizobium-legume symbiosis until discovery that certain Bradyrhizobium strains interacting with Aeschynomene species lack canonical nodABC genes required their synthesis. So far, molecular dialogue between and its symbionts remains an open question. Here we report time course transcriptional analysis evenia in response inoculation ORS278. The NF-independent symbiotic process was monitored at five points...
Spodoptera frugiperda, the fall armyworm (FAW), is an important agricultural pest in Americas and emerging sub-Saharan Africa, India, East-Asia Australia, causing damage to major crops such as corn, sorghum soybean. While FAW larvae are considered polyphagous, differences diet preference have been described between two genetic variants: corn strain (sf-C) rice (sf-R). These strains sometimes distinct species, raising hypothesis that host plant specialization might driven their divergence. To...
In vitro corticogenesis from embryonic stem cells (ESCs) is an attractive model of cortical development and a promising tool for therapy. It unknown to which extent epigenetic mechanisms crucial cortex function, such as parental genomic imprinting, are recapitulated by in corticogenesis. Here, using genome-wide transcriptomic methylation analyses on hybrid mouse tissues cells, we find high concordance imprinting status between vivo ESC-derived cortices. Notably, strictly reproduced the...
Bolder individuals have greater access to food sources and reproductive partners but are also at increased risk of predation. Boldness is believed be consistent across time contexts, few studies investigated the stability this trait variable environments, such as varying stress loads or long periods time. Moreover, underlying molecular components boldness poorly studied. Here, we report that 1154 European sea bass, evaluated using group risk-taking tests, over seven months for subjected...
Sexual reproduction is widespread among eukaryotes, and the sex-determining processes vary greatly species. While genetic sex determination (GSD) has been intensively described in bilaterian species, no example yet recorded non-bilaterians. However, quasi-ubiquitous repartition of GSD multicellular species suggests that similar evolutionary forces can promote this system, these could occur also Studying across range Metazoan diversity indeed important to understand better evolution mechanism...
A bstract Spodoptera frugiperda , the fall armyworm (FAW), is an important agricultural pest in Americas and emerging sub-Saharan Africa, India, East-Asia Australia, causing damage to major crops such as corn, sorghum soybean. While FAW larvae are considered polyphagous, differences diet preference have been described between two genetic variants: corn strain (sf-C) rice (sf-R). These strains sometimes distinct species, raising hypothesis that ost plant specialization might driven their...
Synthetic biology studies how to design and construct biological systems with functions that do not exist in nature. Biochemical networks, although easier control, have been used less frequently than genetic networks as a base build synthetic system. To date, no clear engineering principles such cell-free biochemical networks.We describe methodology for the construction of based on three main steps: design, simulation experimental validation. We developed BioNetCAD help users go through...
Abstract Motivation Allelic imbalance (AI), i.e. the unequal expression of alleles same gene in a single cell, affects subset genes diploid organisms. One prominent example AI is parental genomic imprinting, which results parent-of-origin-dependent, mono-allelic limited number metatherian and eutherian mammals angiosperms. Currently available methods for identifying rely on data modeling come with associated limitations. Results We have designed ISoLDE (Integrative Statistics alleLe...
Lactic acid bacteria, including the microorganisms formerly designated as Lactobacillus , are major representatives of Live Biotherapeutic Microorganisms (LBM) when used for therapeutic purposes. However, in most cases, mechanisms action remain unknown. The antifungal potential LBM has already been demonstrated using preclinical models (cell cultures, laboratory animals). Understanding their is strategic development new therapeutics humans. Here, Caenorhabditis elegans was an vivo model to...
Background Biological invasions are major anthropogenic changes associated with threats to biodiversity and health. What determines the successful establishment of introduced populations still remains unsolved. Here we explore appealing assertion that invasion success relies on immune phenotypic traits would be advantageous in recently invaded sites. Results We compared gene expression profiles between anciently established two invading species, house mouse Mus musculus domesticus black rat...