Barbara Moszczuk
A5022196909- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Renal Transplantation Outcomes and Treatments
- Systemic Sclerosis and Related Diseases
- Biomarkers in Disease Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Pancreatic and Hepatic Oncology Research
- Genetic Associations and Epidemiology
- COVID-19 Clinical Research Studies
- Redox biology and oxidative stress
- Glutathione Transferases and Polymorphisms
- Cancer Genomics and Diagnostics
- Sleep and related disorders
- Transplantation: Methods and Outcomes
- Viral Infections and Immunology Research
- Pregnancy and Medication Impact
- Digestive system and related health
- Sulfur Compounds in Biology
- Renal and Vascular Pathologies
- Case Reports on Hematomas
- Bone and Dental Protein Studies
Medical University of Warsaw
2013-2024
Institute of Biochemistry and Biophysics, Polish Academy of Sciences
2018-2021
Wojskowy Instytut Medycyny Lotniczej
2016
IgA nephropathy (IgAN), membranous (MN), and lupus nephritis (LN) represent important causes of chronic kidney disease. They belong to the immune-mediated glomerulonephritis (GNs), have distinct pathogenesis, clinical courses, variable responses treatment. Therefore, specific diagnostic procedures are necessary for more effective patient management. Recently, a role oxidative stress has been proposed in various renal disorders. Thus, molecules related stress, such as 2-Cys-peroxiredoxins...
The BNT162b2 vaccine is reportedly effective in preventing severe disease more than 90% of the general population, but its efficacy transplant recipients remains controversial. We aimed to determine immune response kidney (KTRs) and liver (LTRs). In this retrospective cohort study, we included randomly 65 KTRs LTRs, who received two 30 μg doses 3-to6-week intervals. analyzed anti-SARS-CoV-2 spike protein IgG antibody (anti-S1 Ab) titer, biochemical renal tests, immunosuppressive drug trough...
The study aim was to evaluate progression-free survival (PFS) and overall (OS) in patients with metastatic clear cell renal carcinoma on sunitinib (SU) SU-everolimus treatment.After 7 years of enrollment 9 follow-up, 193 consecutively presenting (151 men 42 women) were treated.A total 157 (81.3%) died 36 (18.7%) survived. Median PFS SU-treated 14.7 months OS 28.8 months. 13.98 median 26.67 175 treated SU only or SU-everolimus.The development SU-induced hypothyroidism, hypertension,...
Glomerular diseases (GNs) are responsible for approximately 20% of chronic kidney diseases. Glucocorticoid receptor gene (NR3C1) single nucleotide polymorphisms (SNPs) implicated in differences predisposition to autoimmunity and steroid sensitivity. The aim this study was evaluate the frequency NR3C1 SNPs-rs6198, rs41423247 rs17209237-in 72 IgA nephropathy (IgAN) 38 membranous (MN) patients compared 175 healthy controls correlate effectiveness treatment IgAN MN groups defined as a reduction...
Many potential biomarkers in nephrology have been studied, but few are currently used clinical practice. One is osteopontin (OPN). We compared urinary OPN concentrations 80 participants: 67 patients with various biopsy-proven glomerulopathies (GNs)-immunoglobulin A nephropathy (IgAN, 29), membranous (MN, 20) and lupus nephritis (LN, 18) 13 no GN. Follow-up included 48 participants. Machine learning was to correlate other factors classify by GN type. The resulting algorithm had an accuracy of...
Abstract Background Patients with primary biliary cholangitis (PBC) have decreased health‐related quality of life (HRQoL). Here, we investigate HRQoL in two cohorts transplanted patients PBC and compare their results to healthy subjects. Methods We used generic SF‐36 disease‐specific PBC‐40 questionnaires evaluate 26 (23 females, age 59.4 ± 5.7 years) before after liver transplantation (LT), 107 (99 62.8 6.7 who were previously transplanted. The control group was comprised 60 controls (55...
Abstract Background and Aims Multiple factors may contribute to development progression of glomerulopathies (GN), one them is oxidative stress (OS). 2-cysteine-peroxiredoxins (PRDXs) possess the ability reduce excessive levels OS mediators are crucial for cellular regulation. In our pilot study, we found that PRDXs 1-5 differentially changed in patients with IgA nephropathy (IgAN), lupus nephritis (LN) membranous (MN). Thus, aim current study was evaluate if be a prognostic marker these 3...
The 3 leading causes of death in patients after solid organ transplantation (SOT) include cardiovascular diseases, malignancies, and infections. According to our current understanding, the latter play key role pathogenesis atherosclerosis. Similarly, infections (mainly viral) are implicated at least 20% known neoplasms. In other words, implications acute chronic infectious diseases modern medicine, not only transplantology, significant ever‑increasing. Immunosuppressive treatment impairs...
Abstract Background and Aims Oxidative stress (OS) is known as a disturbance between pro- antioxidant factors, that may lead to DNA or protein oxidation, resulting in cellular damage. Peroxiredoxins (PRDXs) are enzymes with an properties. They play dominant role regulation of peroxide levels, which crucial maintaining organisms’ oxidative balance. PRDXs types 1-5 involved the pathophysiology various diseases (e.g. cancer, inflammatory, renal). We aim study their prognostic marker eGFR...