A5015362712- Membrane Separation Technologies
- Advanced Sensor and Energy Harvesting Materials
- Nanoparticle-Based Drug Delivery
- Surface Modification and Superhydrophobicity
- Graphene and Nanomaterials Applications
- Membrane-based Ion Separation Techniques
- Polymer Surface Interaction Studies
- Advanced Polymer Synthesis and Characterization
- Dendrimers and Hyperbranched Polymers
- Nanoplatforms for cancer theranostics
- Hydrogels: synthesis, properties, applications
- Tribology and Wear Analysis
- Electrokinetic Soil Remediation Techniques
- Membrane Separation and Gas Transport
- Synthesis of β-Lactam Compounds
- Asymmetric Hydrogenation and Catalysis
- Phosphorus compounds and reactions
- Supramolecular Chemistry and Complexes
- Environmental remediation with nanomaterials
- Nanocomposite Films for Food Packaging
- Advanced Materials and Mechanics
- Innovative Microfluidic and Catalytic Techniques Innovation
- Curcumin's Biomedical Applications
- Catalytic Processes in Materials Science
- Tea Polyphenols and Effects
North China University of Water Resources and Electric Power
2024
Tiangong University
2006-2024
Tianjin Academy of Environmental Sciences
2024
Nanjing Tech University
2024
Northeastern University
2024
Tianjin University
2013-2022
University of Jinan
2011
The pH-responsive micelles have enormous potential as nanosized drug carriers for cancer therapy due to their physicochemical changes in response the tumor intracellular acidic microenvironment. Herein, a series of comb-like amphiphilic copolymers bearing acetal-functionalized backbone were developed based on poly[(2,4,6-trimethoxybenzylidene-1,1,1-tris(hydroxymethyl) ethane methacrylate-co-poly(ethylene glycol) methyl ether methacrylate] [P(TTMA-co-mPEGMA)] effective nanocarriers curcumin...
Nanoparticle (NP)-assisted drug delivery systems with disassemblable behaviors in response to intracellular microenvironment are urgently demanded systemic cancer chemotherapy for enhanced release. Curcumin (CUR), an effective and safe anticancer agent, was limited by its water insolubility poor bioavailability. Herein, pH reduction dual-induced NPs high loading efficiency improved release of CUR were developed based on acid degradable cyclic benzylidene acetal groups (CBAs)-functionalized...
Membrane biofouling, adhesion of microorganisms on the surface and subsequent formation a biofilm, remains persistent inevitable issue, which results in dramatic reduction permeability lifespan. Constructing membrane with active bacteria-killing passive anti-adhesion properties is still challenge to mitigate biofouling. Herein, an active–passive anti-biofouling was originally fabricated by integration hydrophilic hyperbranched poly(N-acryloylmorpholine) (HPA) dimethylaminoethyl...
Inspired by mussel adhesion chemistry, a kind of hydrophilic poly(vinylidene fluoride) (PVDF) microfiltration membrane with underwater superoleophobicity was prepared using thiolated hyperbranched zwitterionic poly(sulfobetaine methacrylate) (HPS) as nanoscale surface modifier. The HPS first synthesized via reversible addition fragmentation chain transfer (RAFT) copolymerization and followed sulfonation reaction then coated onto polydopamine (PD) adhesive PVDF membranes thiol-mediated...
N-Oxide zwitterionic polyethyleneimine (ZPEI), a new kind of aqueous phase monomer synthesized by commercially branched (PEI) via oxidation reaction, was prepared for fabrication thin-film composite (TFC) polyamide membranes interfacial polymerization. The main factors, including the concentration and immersion time organic phase, were investigated. Compared with PEI-TFC membranes, obtained optimal defect-free ZPEI-TFC exhibited lower roughness (3.3 ± 0.3 nm), better surface hydrophilicity,...
Thermo-sensitive injectable hydrogels based on poly(ε-caprolactone)/poly(ethylene glycol) (PCL/PEG) block copolymers have attracted considerable attention for sustained drug release and tissue engineering applications. Previously, we reported a thermo-sensitive hydrogel of P(CL-co-TOSUO)-PEG-P(CL-co-TOSUO) (PECT) triblock modified by hydrophilic cyclic ether pendant groups 1,4,8-trioxa-[4.6]spiro-9-undecanone (TOSUO). Unfortunately, the low gel modulus PECT (only 50-70 Pa) may limit its...
A novel strategy was purposed to sustainedly deliver drug-loaded nanoparticles (NPs) tumor sites and further enhance intracellular drug release. NPs with the ability of sequential self-gelation self-release in response a tumor-specific microenvironment were developed, which involved conjugation doxorubicin (DOX) on thermosensitive amphiphilic copolymer (poly(ε-caprolactone)-b-poly(ethylene glycol)-b-poly(ε-caprolactone), PCEC) via acid-cleavable hydrazone linkages. The conjugate...
Acid/redox-dual sensitivities of nanoparticles based on PEG/PCL enhance the intracellular drug release cancer cells.
Polymeric nanoparticles assembled from the amphiphilic graft copolymer with cyclic benzylidene acetal-functionalized backbone and short poly(2-hydroxyethyl methacrylate) side chains can remain structurally stable at pH 7.4, but undergo stepwise disassembly in mildly acidic conditions due to acid-triggered cleavage of acetals, providing a promising nanocarrier for cancer therapy.
The introduction of DPA units into a PECD copolymer has an amphoteric effect on the hydrolysis behavior CBAs under acidic conditions.