A5030040285- Orthopedic Infections and Treatments
- Hip and Femur Fractures
- Bone fractures and treatments
- Total Knee Arthroplasty Outcomes
- Surgical site infection prevention
- Cardiac, Anesthesia and Surgical Outcomes
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Orthopaedic implants and arthroplasty
- Circular RNAs in diseases
- Shoulder Injury and Treatment
- Immune cells in cancer
- Tendon Structure and Treatment
- Bone and Joint Diseases
- Spinal Cord Injury Research
- Cancer-related molecular mechanisms research
- Knee injuries and reconstruction techniques
- Antimicrobial Resistance in Staphylococcus
- Osteoarthritis Treatment and Mechanisms
- Sports injuries and prevention
- Extracellular vesicles in disease
- Infectious Diseases and Tuberculosis
- Cell Adhesion Molecules Research
- Periodontal Regeneration and Treatments
- Nerve injury and regeneration
Zunyi Medical University
2016-2024
Beijing Information Science & Technology University
2024
Affiliated Hospital of Zunyi Medical College
2017-2021
Soochow University
2021
Soochow University
2017-2018
Second Affiliated Hospital of Soochow University
2017-2018
Nanjing University of Posts and Telecommunications
2017
Osteoporosis is the most common bone metabolic disease. Exosome exerts a crucial role in development of multiple diseases. The aim study was to investigate exosome derived from marrow mesenchymal stem cells (MSCs) osteoporosis and its underlying mechanism.MSCs were first isolated rat marrow. After surface antigen MSCs identified by flow cytometry, MSCs-derived exosomes (MSC-Exo) extracted. osteogenic lipid differentiation abilities BMSCs determined alizarin red staining oil staining,...
Objective To determine the epidemiological, clinical and microbiological characteristics, of patients with post-traumatic osteomyelitis extremity fractures, provide evidence-based guidelines for early diagnosis treatment, including empiric antibiotic therapy. Methods Human subject research was performed using institutional review board approved protocols. A retrospective chart conducted on 5,368 diagnosed traumatic fractures from January 1, 2012 to December 31, 2015, identify patients....
Abstract Bone infection represents a serious complication of orthopedic surgery and Staphylococcus aureus is the most common pathogen. To improve understanding host‐pathogen interaction, we developed biospecimen registry ( AO Trauma CPP Infection Registry ) to collect clinical data, bacterial isolates, serum from patients with S. bone infection. A prospective multinational 12‐month follow‐up was created include adult (18 years or older) culture‐confirmed in long bones after fracture fixation...
Osteoarthritis (OA) is a multi-factorial chronic joint disease mainly identified by synovial inflammation, cartilage damage, and degeneration. Our study applied bioinformatics analysis to uncover the immunity in OA tried explore underlying immune-related molecular mechanism. First, OA-related gene-expression profiling data were retrieved from GEO database. Then, we analysed series of datadata with using xCell algorithm, GEO2R, enrichment SangerBox website, CytoHubba, ROC logistic regression...
Mesenchymal stem cells (MSCs) are multipotent that can skew the balance of M1/M2 macrophage polarization towards M2 phenotype via their paracrine effects, thereby promoting anatomical and functional recovery after many inflammatory diseases induced by macrophages. However, underlying mechanism is still poorly understood. This study focused on IL-10/STAT3 pathway investigated whether IL-10 secreted PBMSCs could mediate through activation this pathway. In study, a Transwell system was used for...
Chronic osteomyelitis is a serious complication of orthopedic trauma. Residual bacteria after incomplete debridement and/or bacterial colonization, biofilm formation, and generation antibiotic-resistant strains in the microtubule system compact bones due to irrational use antibiotics often make condition more prolonged, recurrent, refractory. The passive immunotherapy targeting protein components has become an area intense research interest, for which identifying isolates different areas at...
The aim of the present study was to investigate role microRNA (miRNA or miR)-140 in C3H10T1/2 mesenchymal stem cells (MSCs). Cluster analysis used evaluate miRNA expression profile. level miRNA‑140 validated by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR). TargetScan and microRNA.org databases were predict target miRNAs cartilage‑associated genes. Binding sites between miR‑140 gene predicted bioinformatics software. A dual‑luciferase reporter assay performed...
Abstract Background Traditional total hip arthroplasty (THA) using the direct anterior approach (DAA) requires a extension. This study aimed to compare clinical outcomes of patients undergoing THA with DAA either no extension (NHE) or traditional (THE) strategy. Methods A retrospective analysis demographics, and radiological outcomes, occurrence complications was performed data from 123 treated between January 2020 November 2021. The were categorised into two groups: NHE (84 patients) THE...
With the increasing demand for exercise, population of patients with ankle sprain to anterior talofibular ligament injury has characteristics a large base and high requirements returning sports, how promote repair damaged ligaments from microscopic perspective is an urgent problem be solved. In many studies, human amniotic mesenchymal stem cells have strong differentiation ability, can induced continuously differentiate into achieve purpose repairing ligaments. Human were extracted cultured...
Abstract Background The incidence of adverse perioperative outcomes in surgery for femoral fractures is high and associated with malnutrition. Here, we identified independent factors assessed the predictive value prognostic nutritional index (PNI) patients fractures. Methods This retrospective study included 343 who underwent a single femur fracture. Demographic characteristics, anaesthesia records blood test results at admission, 1 day postoperatively before discharge were evaluated using...
Objective: To investigate the pituitary hormone changes of patients with craniopharyngioma different growth patterns during perioperative period and follow up time. Methods: Retrospective studies were performed on 212 cases primary patient who received total tumor excision surgery in our hospital from January 2001 to May 2012. The characteristics associated clinical manifestation preoperative, postoperative periods analyzed according QST surgical classification. Results: One hundred...
The major limitations of clinical outcome predictions osteomyelitis mediated by Staphylococcus aureus (S. aureus) are not specific and definitive. To this end, current studies aim to investigate host immune responses trend changes the iron-regulated surface determinant (Isd) IsdA, IsdB, IsdH, cell wall-modifying proteins amidase (Amd) glucosaminidase (Gmd), secreted virulence factor chemotaxis inhibitory protein S. (CHIPS) staphylococcal complement inhibitor (SCIN) longitudinally discover...
Total hip arthroplasty (THA) performed using the direct anterior approach (DAA) has demonstrated favourable early-, mid-, and long-term outcomes. However, traditional femoral release technique remains technically demanding is associated with challenges a heightened risk of complications. This study aimed to compare clinical outcomes patients who underwent THA DAA either femoral-release-first (FRF) or (TA) strategy.A retrospective analysis demographics, radiological outcomes, occurrence...
To evaluate the short-term effectiveness of modified arthroscopic Latarjet procedure with double EndoButtons for recurrent anterior shoulder dislocation.Between January 2019 and November 2020, 36 patients dislocation were treated by EndoButtons. There 26 males 10 females, an average age 27.8 years (range, 18-36 years). The number dislocations ranged from 3 to 12 times, 6.5 times. disease duration 5 months, 16.2 months. Preoperative fear test was positive, Beighton score joint relaxation 0-4,...
Abstract Background Bone is one of the most common sites advanced tumors. However, there currently a lack population-based surveys for incidence and prognosis bone metastases in solid cancers. Methods Patients with 12 types primary cancer at initial diagnosis between 2010 2015 were identified using Surveillance, Epidemiology, End Results (SEER) database. The Kaplan-Meier method Cox logistic regression conducted to analyze survival effect on different We included 89,782 patients diagnosis....
Abstract Background : Surgery is usually the best treatment for patients with femoral fractures. However, incidence of perioperative adverse outcomes in such cases quite high. Nutrition has a major influence on fracture healing, and malnutrition associated higher complication rates, mortality longer hospitalisation periods. In this study, we aimed to identify independent risk factors assess predictive value prognostic nutritional index (PNI) Methods This retrospective observational study...