A5101828828- Mesenchymal stem cell research
- Periodontal Regeneration and Treatments
- Fungal and yeast genetics research
- Cellular transport and secretion
- Dental Trauma and Treatments
- Tissue Engineering and Regenerative Medicine
- dental development and anomalies
- Cellular Mechanics and Interactions
- Toxin Mechanisms and Immunotoxins
- Cancer Cells and Metastasis
- Plant Reproductive Biology
- Pancreatic and Hepatic Oncology Research
- Foot and Ankle Surgery
- Flavonoids in Medical Research
- Healthcare and Venom Research
- 14-3-3 protein interactions
- Natural Products and Biological Research
- Pancreatic function and diabetes
- Proteoglycans and glycosaminoglycans research
- Seaweed-derived Bioactive Compounds
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Herbal Medicine Research Studies
- Clusterin in disease pathology
- Neuroendocrine regulation and behavior
- Menstrual Health and Disorders
Jining Medical University
2025
Binzhou Medical University
2025
Shandong University of Traditional Chinese Medicine
2024
Air Force Medical University
2012-2021
Southwest University
2021
Hebei General Hospital
2017
Beijing University of Technology
2017
Tianjin University of Traditional Chinese Medicine
2013-2016
Xijing Hospital
2016
Cornell University
2004-2010
Abstract Background Periodontitis, which progressively destroys tooth-supporting structures, is one of the most widespread infectious diseases and leading cause tooth loss in adults. Evidence from preclinical trials small-scale pilot clinical studies indicates that stem cells derived periodontal ligament tissues are a promising therapy for regeneration lost/damaged tissue. This study assessed safety feasibility using autologous (PDLSCs) as an adjuvant to grafting materials guided tissue...
Bud growth in yeast is guided by myosin-driven delivery of secretory vesicles from the mother cell to bud. We find transport occurs along two sets actin cables assembled formin isoforms. The Bnr1p assembles that radiate bud neck into mother, providing a stable mother-bud axis. These also depend on septins at and are required for efficient Bni1p line cortex target varying locations Loss these results morphological defects as accumulate neck. Assembly depends continued polarized secretion,...
The aim of this study was to compare the properties stem cells derived from "inflamed" and healthy periodontal ligament (PDL) tissues patient-matched groups.Patient-matched root-attached PDL six donors, termed I-PDLSCs H-PDLSCs, respectively, were investigated with regard their cell properties, immunomodulatory effects capacity form robust sheets for therapeutic applications.We found that both sources exhibited typical mesenchymal (MSC) characteristics. However, compared demonstrated an...
ABSTRACT Targeting activated macrophages using anti‐inflammatory phytopharmaceuticals has been proposed as general therapeutic approaches for rheumatic diseases. Besides macrophages, chondrocytes are another promising target of agents. Tetrandrine is a major bisbenzylisoquinoline alkaloid isolated from Stephania tetrandrae S. Moore which used 2,000 years an antirheumatic herbal drug in China. Although, the effect tetrandrine demonstrated, mechanism not clearly clarified. In this study, we...
Aim and Objective To evaluate the effect of rehabilitation exercises combined with Direct Vagina Low Voltage Frequency Electric Stimulation ( DES ) on pelvic nerve electrophysiology tissue function after delivery. Background Whether how effects floor dysfunction PFD are not known clearly. Design This was a randomised, controlled clinical trial. Methods The 189 primiparous women 20–35 years old an episiotomy or second degree tear were divided into three groups: control group n = 60) received...
Directing cell trafficking toward a target site of interest is critical for advancing stem therapy in clinical theranostic applications. In this study, we investigated the effects inflammatory and/or hypoxic stimuli on migration bone marrow mesenchymal cells (BMMSCs) during vitro culture and after vivo implantation. Using tablet scratch experiments observations from transwell system, found that both significantly enhanced migration. However, combination did not result synergistic effect. The...
Periodontal ligament stem cells (PDLSCs) derived from clinically compromised teeth with periodontitis are considered a readily accessible cell source, but their impaired functionalities, as observed in various vitro and vivo models, necessitate further investigation of these inflamed before translation into therapeutic applications. In this study, the effects conditioned media (CM) produced by human healthy periodontal tissues (H-PDLSCs) or (I-PDLSCs), referred to H-CM I-CM, respectively, on...
Significance During embryonic development, an early-stage progenitor cell could generate different types of descendant cells. Developmental biologists keep dreaming making all the generated by each clear. Here, we focus on one germ layer, endoderm. Early foregut endoderm generates digestive organs, including pancreas, liver, and tract. The central point this work is establishment a full-coverage, single-cell–resolution fate map zebrafish early through unbiased labeling every single...
Formins are conserved eukaryotic proteins that direct the nucleation and elongation of unbranched actin filaments. The yeast formins, Bni1p Bnr1p, assemble cables from bud cortex neck, respectively, to guide overall cell polarity. Here we examine regions Bnr1p responsible for neck localization. We define two non-overlapping regions, Bnr1p-L1 (1-466) Bnr1p-L2 (466-733), can each localize independently endogenous Bnr1p. with septins at but show slightly differently spatial temporal...
Human platelet lysate (PL) produced under optimal conditions of standardization and safety has been increasingly suggested as the future 'gold standard' supplement to replace fetal bovine serum (FBS) for ex vivo propagation mesenchymal stem cells translational medicine cell therapy applications. However, multifaceted effects PL on tissue-specific remain largely unexplored. In present study, we investigated behaviours human periodontal ligament (PDLSCs) in media with or without PL. Our data...
Formins are regulated actin-nucleating proteins that widespread among eukaryotes. Overexpression of unregulated formins in budding yeast is lethal and causes a massive accumulation disorganized cable-like filaments. To explore the basis this lethality, cDNA library was screened to identify whose overexpression could rescue lethality conferred by Bnr1p expression. Three classes suppressors encoding actin-binding were isolated. One class encodes promote assembly actin cables (TPM1, TPM2,...
Polarity is achieved partly through the localized assembly of cytoskeleton. During growth in budding yeast, bud cortex and neck formins Bni1p Bnr1p nucleate assemble actin cables that extend along bud-mother axis, providing tracks for secretory vesicle delivery. Localized are believed to determine location polarity cables, hence growth. However, yeast expressing nonlocalized nucleating/assembly formin homology (FH) 1-FH2 domains or as sole grow well. Although significantly disorganized,...
Baicalin and baicalein are flavonoid compounds derived from Scutellaria baicalensis Georgi. These have been used in the treatment of numerous diseases, including fibrotic diseases. However, research regarding their antifibrotic effects mechanism action renal fibrosis is limited. In present study, normal rat kidney interstitial fibroblast (NRK-49F) cells were stimulated with transforming growth factor (TGF)-β1, or without baicalin/baicalein, assessed for proliferation, apoptosis,...
The new methods of different administration times for the treatment primary dysmenorrhea are more widely used clinically; however, no obvious mechanism has been reported. Therefore, an animal model which is closer to clinical evaluation indispensable. A novel experiment with times, based on mice oestrous cycle, dysmenorrhoea was explored in this study. Mice were randomly divided into two parts (one-cycle and three-cycle part) each part includes five groups (12 per group), namely, Jingqian...
Introduction. Bone marrow-derived mesenchymal stromal cells (BMSCs) have emerged as promising cell candidates but with poor survival after transplantation. This study was designed to investigate the efficacy of VEGF, bFGF, and IGF-1 on BMSCs' viability proliferation both in vivo vitro using bioluminescence imaging (BLI). Methods. BMSCs were isolated from β-actin-Fluc(+) transgenic FVB mice, which constitutively express firefly luciferase. Apoptosis induced by hypoxia preconditioning for up...