A5009956903- Mesenchymal stem cell research
- Periodontal Regeneration and Treatments
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Neurogenesis and neuroplasticity mechanisms
- MicroRNA in disease regulation
- Wound Healing and Treatments
- Proteoglycans and glycosaminoglycans research
- Pregnancy and preeclampsia studies
- Peptidase Inhibition and Analysis
- Protease and Inhibitor Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve injury and regeneration
- Hemostasis and retained surgical items
- Pluripotent Stem Cells Research
- Circular RNAs in diseases
- Osteoarthritis Treatment and Mechanisms
- Bone Tissue Engineering Materials
- dental development and anomalies
- Cardiac Fibrosis and Remodeling
- 3D Printing in Biomedical Research
- Biomedical Ethics and Regulation
- Platelet Disorders and Treatments
University of Antwerp
2021
Hasselt University
2014-2020
Morpho (United States)
2016
Biomedical Research Institute
2016
John Wiley & Sons (United States)
2016
Cell-based therapies are emerging as an alternative treatment option to promote functional recovery in patients suffering from neurological disorders, which the major cause of death and permanent disability. The present study aimed differentiate human dental pulp stem cells (hDPSCs) toward functionally active neuronal vitro. hDPSCs were subjected a two-step protocol. First, induction was acquired through formation neurospheres, followed by maturation, based on cAMP neurotrophin-3 (NT-3)...
Adequate vascularization, a restricting factor for the survival of engineered tissues, is often promoted by addition stem cells or appropriate angiogenic growth factors. In this study, human dental pulp (DPSCs) and from apical papilla (SCAPs) were applied in an vivo model regeneration order to compare their regenerative potential confirm previously demonstrated paracrine properties. 3D-printed hydroxyapatite scaffolds containing DPSCs and/or SCAPs subcutaneously transplanted into...
Abstract Leukocyte- and Platelet-Rich Fibrin (L-PRF) is an autologous platelet concentrate, consisting of a fibrin matrix enriched with platelets, leukocytes plethora cytokines growth factors. Since L-PRF produced bedside from whole blood without the use anti-coagulant, it becoming popular adjuvant in regenerative medicine. While other types concentrates have been described to stimulate vessel formation, little known about angiogenic capacities L-PRF. Therefore, this study aimed fully...
Periodontal ligament stem cells (PDLSCs) represent a good source of multipotent for cell-based therapies in regenerative medicine. The success rate these treatments is severely dependent on the establishment adequate vasculature order to provide oxygen and nutrients transplanted cells. Pharmacological preconditioning has been proposed as promising method augment their therapeutic efficacy. In this study, aim was improve intrinsic angiogenic properties PDLSCs by vitro pretreatment with...
Abstract In preeclampsia (PE), pre-existent maternal endothelial dysfunction leads to impaired placentation and vascular maladaptation. The growth factor (VEGF) pathway is essential in the process VEGF expression regulated through post-transcriptional modification by microRNAs (miRNAs). We investigated of VEGF-related circulating miR-16, miR-29b, miR-126, miR-155 miR-200c PE vs healthy pregnancies (HPs), their relation with function, oxidative stress (OS) systemic inflammation. this...
Fibroblast activation protein-α (FAPα) is a membrane protein with dipeptidyl-peptidase and type I collagenase activity expressed during fetal growth. At the age of adolescence, FAPα expression greatly reduced, only emerging in pathologies associated extracellular matrix remodeling. We determined whether human dental tissue involved root maturation i.e., follicle apical papilla pulp tissue. The revealed high concentration vimentin-positive cells within stromal A similar observation was made...
Pathologies of the central nervous system are characterized by loss brain tissue and neuronal function which cannot be adequately restored endogenous repair processes. This stresses need for novel treatment options such as cell-based therapies that able to restore damaged or stimulate repair. study investigated neuroregenerative potential conditioned medium human dental pulp stem cells (CM-hDPSCs) on neural cell (NSC) proliferation migration well neurite outgrowth primary cortical neurons...