Abstract Bacterial infections pose a serious threat to human health. Photodynamic therapy is an effective medical treatment solve the problems raised by antibiotic resistant bacteria. But it not easy have photosensitizers (PSs) that can simultaneously produce efficient fluorescence and reactive oxygen species. Traditional PSs show compromised performances due aggregation‐caused quenching effect in aqueous media, however, luminogens with aggregation‐induced emission (AIE) inherently achieve...

Multidrug resistance (MDR) bacteria pose a serious threat to human health. The development of alternative treatment modalities and therapeutic agents for treating MDR bacteria-caused infections remains global challenge. Herein, series near-infrared (NIR) anion-π+ photosensitizers featuring aggregation-induced emission (AIE-PSs) are rationally designed successfully developed broad-spectrum eradication. Due the strong intramolecular charge transfer (ICT) enhanced highly efficient intersystem...

Phototheranostics has received sustained attention due to its great potential in revolutionizing conventional strategies of cancer treatment. However, trapped by the complexity, poor reproducibility, insufficient phototheranostic outputs, and inevitable damage normal tissue most multicomponent systems, clinical translation been severely hindered. Therefore, exploration "one for all" smart agents with versatile functionalities remains an appealing yet enormously challenging task. Herein, a...

Rapid wound dressing and effective antibacterial therapy that meet the extreme requirements of emergency situations are urgently needed for treating skin wounds. Here, an in situ deposited personalized nanofibrous is reported which can be directly electrospun on wounds by a handheld electrospinning device perfectly fits different various sizes. Moreover, aggregation-induced emission luminogen with photodynamic effect loaded dressings endows dressing's long-term activity during healing...

Bacteria infected cells acting as "Trojan horses" not only protect bacteria from antibiotic therapies and immune clearance, but also increase the dissemination of pathogens initial sites infection. Antibiotics are hard insufficient to treat such hidden internalized bacteria, especially multidrug-resistant (MDR) bacteria. Herein, aggregation-induced emission luminogens (AIEgens) N,N-diphenyl-4-(7-(pyridin-4-yl) benzo [c] [1,2,5] thiadiazol-4-yl) aniline functionalized with 1-bromoethane...

Phototheranostics involving both fluorescence imaging and photodynamic therapy has been recognized to be potentially powerful for cancer treatment by virtue of various intrinsic advantages. However, the state-of-the-art materials in this area are still far from ideal toward practical applications, ascribed their respective collective drawbacks, such as inefficient quality, inferior reactive oxygen species (ROS) production, lack subcellular-targeting capability, dissatisfactory delivery. In...

The intense metabolism of cancer cells leads to hypoxia and lack crucial nutrients in the tumor microenvironment, which hinders function immune cells. We designed a biomimetic metabolic nanoplatform, type I aggregation-induced emission photosensitizer glutamine antagonist are encapsulated into cell membrane for achieving specific delivery vivo. This approach greatly satisfies glucose required by T cells, significantly improves hypoxic environment, enables reprogramming metabolism, induces...

The unique steric effect of geminal bis(silane) [(R3Si)2CH] allows an exo-selective intermolecular Diels-Alder reaction bis(silyl) dienes with α,β-unsaturated carbonyl compounds. approach shows good generality to form ortho-trans cyclohexenes in yields high exo-selectivity and enantioselectivity some asymmetric cases. excellent exo-stereocontrol aptitude (R3Si)2CH group is highlighted by comparing R3SiCH2 R3Si groups, which leads endo-selectivity predominantly. conformational analysis...

Abstract Phototheranostics based on luminogens with aggregation‐induced emission (AIE) characteristics is captivating increasing research interest nowadays. However, AIE are inherently featured by inferior absorption coefficients (ε) resulting from the distorted molecular geometry. Besides, innovation of long‐wavelength light‐excitable highly efficient phototheranostic outputs an appealing yet significantly challenging task. Herein, basis a fused‐ring electron acceptor–donator–acceptor...

Background: Activated hepatic stellate cells (aHSCs) play a significant role during the onset of fibrosis, ultimately leading to excessive deposition extracellular matrix (ECM) and other typical pathological features, thus have become popular target for treatment fibrosis. However, current aHSC-centric therapy strategies achieve unsatisfactory results, mainly due lack approved anti-fibrosis drugs sufficiently efficient aHSC-targeted delivery systems. In this study, our aim was develop an...

Circular RNAs (circRNAs) serve a crucial regulatory role in ovarian cancer (OC). RNA ArfGAP with FG repeats 1 (circAGFG1) has been shown to be involved promoting the progression of several cancers, containing triple-negative breast cancer, esophageal and colorectal cancer. However, function circAGFG1 OC is unclear.

As two important subcellular organelles in eukaryotic cells, the Golgi apparatus (GA) and endoplasmic reticulum (ER) have recently captivated much interest due to their considerable importance many biofunctions role as critical biomarkers for various diseases.

Tumor metastasis is an intricate multistep process regulated via various proteins and enzymes modified secreted by swollen Golgi apparatus in tumor cells. Thus, complex considered as important target for the remedy of metastasis. Currently, targeting technologies are mostly employed Golgi-specific fluorescent probes diagnosis, but their applications therapy rarely reported. Herein, we proposed a prodrug (INR) that can destroy apparatus, which consisted indomethacin (IMC) moiety retinoic acid...

Abstract The air‐stable unsymmetrical disilane Me 3 Si−SiMe 2 [ o CON( i Pr) C 6 H 4 ] has been developed for bis‐silylation of alkynes. This reagent tolerates a range functional groups, providing Z ‐vinyl disilanes in high yields. It is proposed that the phenyl‐ring‐tethered amide group directs oxidative addition Pd 0 into Si−Si bond, which might facilitate formation six‐membered cycle, generating products with good to excellent regioselectivity.

A sequential one-pot process for chemoselectively reducing sterically demanding N,N-diisopropylamides to aldehydes has been developed. In this reaction, amides are activated with EtOTf form imidates, which reduced LiAlH(OR)3 [R = t-Bu, Et] give by hydrolysis of the resulting hemiaminals. The non-nucleophilic base 2,6-DTBMP remarkably improves reaction efficiency. combination EtOTf/2,6-DTBMP and LiAlH(O-t-Bu)3 was found be optimal alkyl, alkenyl, alkynyl, 2-monosubstituted aryl...

An intramolecular [1,4]-S- to O-silyl migration has been used form silyl enol ethers with Z-configurational control. The also creates a new anion center at sulfur, which can subsequently react electrophiles generate Z-silyl diverse thioether linkages. synthetic utility of this pathway was demonstrated by modifying the aldehydes via Mukaiyama aldol reaction or Prins cyclization functionalized organosulfur compounds.

Abstract The air‐stable unsymmetrical disilane Me 3 Si−SiMe 2 [ o CON( i Pr) C 6 H 4 ] has been developed for bis‐silylation of alkynes. This reagent tolerates a range functional groups, providing Z ‐vinyl disilanes in high yields. It is proposed that the phenyl‐ring‐tethered amide group directs oxidative addition Pd 0 into Si−Si bond, which might facilitate formation six‐membered cycle, generating products with good to excellent regioselectivity.

Background: Doxorubicin (DOX) is a leading chemotherapeutic in cancer treatment because of its high potency and broad spectrum. Liposomal doxorubicin (Doxil®) the first FDA-approved PEG-liposomes DOX for over 600,000 patients, it can overcome doxorubicin-induced cardiomyopathy other side effects prolong life span. The addition MPEG2000-DSPE could elevate total cost treatment. Objective: We intended to prepare novel liposome that was prepared with inexpensive materials egg yolk lecithin...

Glaucoma is a leading cause of irreversible blindness worldwide and characterized by progressive loss retinal ganglion cells (RGCs). As glaucoma progresses asymptomatically the lack specific biomarkers or noninvasive imaging tools during early stage, it often discovered at relatively late stage without cure. Development an effective tool for diagnosis remains necessity. well known, endoplasmic reticulum (ER) stress subsequent accumulation reactive oxygen species (ROS) play vital role in...

Multidrug resistance (MDR) bacteria pose a serious threat to human health. The development of alternative treatment modalities and therapeutic agents for treating MDR bacteria-caused infections remains global challenge. Herein, we rationally designed successfully developed series near-infrared (NIR) anion-π+ photosensitizers featuring aggregation-induced emission (AIE-PSs) broad-spectrum eradication. Due the strong intramolecular charge transfer (ICT) enhanced highly efficient intersystem...