A5078561239- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Advanced biosensing and bioanalysis techniques
- Hydrogels: synthesis, properties, applications
- 3D Printing in Biomedical Research
- DNA and Nucleic Acid Chemistry
- Polymer Surface Interaction Studies
- RNA Interference and Gene Delivery
- Biomedical and Engineering Education
- Corneal Surgery and Treatments
- Biomedical Ethics and Regulation
- Advanced Cellulose Research Studies
- Silk-based biomaterials and applications
- Medical Device Sterilization and Disinfection
- EEG and Brain-Computer Interfaces
- Orthopaedic implants and arthroplasty
- Nanoparticle-Based Drug Delivery
- Molecular Sensors and Ion Detection
- Stroke Rehabilitation and Recovery
- Ocular Surface and Contact Lens
- Attention Deficit Hyperactivity Disorder
- Surface Modification and Superhydrophobicity
- Biosensors and Analytical Detection
- Nanoplatforms for cancer theranostics
- Health and Medical Research Impacts
Sichuan University
2018-2024
West China Medical Center of Sichuan University
2021-2022
Centre for Innovation in Regulatory Science
2021
Chengdu University
2021
Tokyo Women's Medical University
2006-2014
RIKEN
2004-2007
Kyushu University
2001-2004
In the past two decades, as a novel approach for tissue engineering, cell sheet engineering has been proposed by our laboratory. Poly(N-isopropylacrylamide) (PIPAAm), which is well-known temperature-responsive polymer, grafted on culture polystyrene (TCPS) surfaces through an electron beam irradiated polymerization. At 37 °C, where PIPAAm modified surface hydrophobic, cells can adhere, spread and grow to confluence. By decreasing temperature 20 since turns hydrophilic, detach themselves from...
ABSTRACT Poly( N ‐isopropylacrylamide) (PIPAAm), which is a well‐known temperature‐responsive polymer, modified on substrates by various methods. At 37 °C, PIPAAm surface hydrophobic and allows cells to adhere proliferate the surface. By reducing temperature below lower critical solution of PIPAAm, turns hydrophilic detach themselves from spontaneously. With this technology, cell sheet engineering established several years ago. This review focuses preparations characteristics PIPAAm‐modified...
Two types of turbidimetric detection adenosine 5′-triphosphate (ATP) by the naked eye were achieved through a combination non-cross-linking aggregation DNA-linked polymeric micelles and molecular recognition ATP DNA aptamer.
The attachment of bio-foulants can lead to implantation failure intraocular lens (IOL). A facile strategy is provided prepare a hydrophilic anti-biofouling coating on IOL. “bridge” increase the adhesion between and
Colloidal behaviors of particles functionalized with biomolecules are generally complicated. This study describes that colloidal double-stranded (ds) DNA-carrying polymer micelles well controlled by altering the molar ratio single-stranded (ss) DNA moiety in dsDNA shell. ssDNA-carrying composed a poly(N-isopropylacrylamide) (PNIPAAm) core surrounded dense shell ssDNAs were prepared through self-assembly PNIPAAm grafted ssDNA incubating its solution above lower critical temperature....
Abstract The DNA-linked colloidal nanoparticle was prepared through the phase transition of amphiphilic copolymer consisting DNA as hydrophilic part and thermo-responsive poly(N-isopropylacrylamide) hydrophobic part. We have succeeded in detecting single nucleotide difference 39-mer target by using a salt-induced aggregation particles.
In this study, we fabricated native tissue mimicking a bilayered small-diameter vascular graft based on PEGylated chitosan (PEG–CS) and poly(l-lactic acid- co- ε-caprolactone) (PLCL). PEG–CS possesses good hemocompatibility, as the inner layer of graft, it is more likely to swell deform debris, causing blood clot, so PLCL was added stabilize it. order optimize performance layer, blends with different ratios (P/C:PLCL) casting films were fabricated, endothelial cell compatibility...
Background: Doxorubicin (DOX) is a leading chemotherapeutic in cancer treatment because of its high potency and broad spectrum. Liposomal doxorubicin (Doxil®) the first FDA-approved PEG-liposomes DOX for over 600,000 patients, it can overcome doxorubicin-induced cardiomyopathy other side effects prolong life span. The addition MPEG2000-DSPE could elevate total cost treatment. Objective: We intended to prepare novel liposome that was prepared with inexpensive materials egg yolk lecithin...
Attention deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental among children and adolescents. Behavioral detection analysis play crucial role in ADHD diagnosis assessment by objectively quantifying impulsivity symptoms. Existing video-based action recognition algorithms focus on object or interpersonal interactions, they may overlook ADHD-specific behaviors. Current keypoints-based algorithms, although effective attenuating environmental interference, struggle to...
We proposed a novel approach to quantitatively estimate the strength of cell-material interaction by using microfluidic system. The device was made poly (dimethylsiloxane) chip bonding on temperature-responsive cell culture surface consisted poly(N-isopropylacrylamide) (PIPAAm) grafted tissue polystyrene (TCPS) (PIPAAm-TCPS), containing five parallel test channels for culture. This construction allows concurrent generating different shear forces applied cells in each microchannel varying...
The poly(<sc>l</sc>-lactide-<italic>b-N</italic>-vinyl-2-pyrrolidone) network could be formed by UV curing, and resist the adhesion of L929 fibroblasts. It used in field biological anti-fouling material with customization requirements.
The poly( l -lactide- co -ε-caprolactone- co-N -vinyl-2-pyrrolidone) network formed by UV curing could resist the adhesion of L929 fibroblasts, platelets and bacteria. It be used in field customized biomaterials with biological anti-fouling.