A5077425886- Genetics, Aging, and Longevity in Model Organisms
- Nanoparticle-Based Drug Delivery
- Microbial Metabolic Engineering and Bioproduction
- Fermentation and Sensory Analysis
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Bee Products Chemical Analysis
- Sesquiterpenes and Asteraceae Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Spectroscopy and Chemometric Analyses
- Connective Tissue Growth Factor Research
- Thallium and Germanium Studies
- Advanced Drug Delivery Systems
- GABA and Rice Research
- Cultural Heritage Materials Analysis
- Traditional Chinese Medicine Analysis
- Amyotrophic Lateral Sclerosis Research
- Food Quality and Safety Studies
- Parkinson's Disease Mechanisms and Treatments
- Phytochemicals and Antioxidant Activities
- Cancer therapeutics and mechanisms
- Lung Cancer Research Studies
- Nanoplatforms for cancer theranostics
- Protease and Inhibitor Mechanisms
- Dental Erosion and Treatment
University of Cambridge
2025
MRC Mitochondrial Biology Unit
2025
Medical Research Council
2025
Guiyang University
2024-2025
Canterbury Christ Church University
2017-2020
Sichuan University
2020
King's College London
2016-2019
China Pharmaceutical University
2010-2012
Northeast Forestry University
2006
Tang Du Hospital
1994
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are primarily genetic in ~20% of patients. Mutations C9ORF72 the most frequent cause, but it is not understood why there notable regional pathology. An increased burden mitochondrial DNA (mtDNA) mutations ALS-FTLD brains implicates mechanisms; however, remains unclear how when these arise. To address this, we generated cerebral organoids derived from human-induced pluripotent stem cells (hiPSCs) patients with...
Background: Blueberry anthocyanin such as Cyanidin-3-O-glucoside may help prevent Alzheimer’s disease. We aimed to investigate the preventive and therapeutic effects of against Aβ1–42-induced apoptosis SH-SY5Y cells well underlying mechanisms. Methods: Cell viability intracellular mitochondrial reactive oxygen species were detected by MTT, a detection kit, MitoSOX red superoxide indicator. The membrane potential, calcium ion content, adenotriphophate (ATP) identified via potential ATP was...
A GENiE (EU COST action, www.worm-genie.eu) workshop was held at the Babraham Institute in Cambridge, UK on April 19 and 20, 2017, to discuss global challenges around Caenorhabditis elegans metabol...
The incidence of obesity is rising at an alarming rate. Despite its recognition as urgent healthcare concern, remains largely unsolved medical problem. A comprehensive screen for functional dietary phytochemicals identified proanthocyanidins putative targets to ameliorate obesity. full-scale purification oligomeric (OPCs) derived from grape seed extract yielded pure OPC dimer, trimer, tetramer, and their gallates (pOPCs). Forward chemical screening conducted in Caenorhabditis elegans...
Excessive expression of CTGF (connective tissue growth factor)/CCN2 has been observed in many fibrotic diseases. The inhibition the CTGF/CCN2 by antibody shown to be clinically useful for management fibrosis. A phage display humanized single-chain Fv library was screened using CTGF/C (CTGF/CCN2 C-terminal domain) as target. ELISA performed after four rounds biopanning, and ten positive clones were further evaluated chosen DNA sequencing. encoding scFv (single-chain variable fragment)...
Background: Doxorubicin (DOX) is a leading chemotherapeutic in cancer treatment because of its high potency and broad spectrum. Liposomal doxorubicin (Doxil®) the first FDA-approved PEG-liposomes DOX for over 600,000 patients, it can overcome doxorubicin-induced cardiomyopathy other side effects prolong life span. The addition MPEG2000-DSPE could elevate total cost treatment. Objective: We intended to prepare novel liposome that was prepared with inexpensive materials egg yolk lecithin...
Different genetic backgrounds can modify the effect of mutated genes. Human α-synuclein (SNCA) gene encodes α-synuclein, and its oligomeric complexes accumulate with age mediate disruption cellular homeostasis, resulting in neuronal death that is characteristic Parkinson’s Disease. Polymorphic variants modulate this complex pathologic mechanism. Previously, we constructed five transgenic introgression lines a Caenorhabditis elegans model using are genetically diverse from canonical wild-type...
In vivo lipid saturation maps of microscopic nematodes (Caenorhabditis elegans) have been produced using our novel Spectral Interferometric Polarisation Coherent anti-Stokes Raman Scattering (SIP-CARS) imaging technique. This technique employs simple passive polarisation optics and a balanced homodyne detection scheme to exploit symmetries in the CARS response resulting complete cancellation non-resonant background (NRB) real component signal (with no prior or post assumptions as regards...
Broadband coherent anti-Stokes Raman scattering (B-CARS) in a hybrid 2-color/3-color excitation regime has been shown to be photon-efficient method of generating CARS across the entire vibrational region interest (fingerprint and C-H stretch). We extend here our spectral interferometric polarized (SIP-CARS) approach regime, demonstrate that power/polarization dependence for both 2- color 3-color agrees with theory, explore application SIP-CARS special case anisotropic, birefringent materials...