A5082473422- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cellular Mechanics and Interactions
- Bacillus and Francisella bacterial research
- Antibiotic Resistance in Bacteria
- Bacteriophages and microbial interactions
- Bacterial biofilms and quorum sensing
- Microbial Inactivation Methods
- Immune Response and Inflammation
- Gut microbiota and health
- Force Microscopy Techniques and Applications
- Cell Adhesion Molecules Research
- Antimicrobial Peptides and Activities
- Microbial infections and disease research
- Vibrio bacteria research studies
- Antimicrobial Resistance in Staphylococcus
- Inflammasome and immune disorders
- Pharmacological Effects of Natural Compounds
- Microtubule and mitosis dynamics
- S100 Proteins and Annexins
- 3D Printing in Biomedical Research
- Viral gastroenteritis research and epidemiology
- Cancer and biochemical research
- Ginseng Biological Effects and Applications
- Flavonoids in Medical Research
- Molecular Sensors and Ion Detection
Beijing University of Agriculture
2015-2025
China Agricultural University
2016-2025
Peking University
2020-2021
University of Göttingen
2017
Nanjing Agricultural University
2017
Bacteria infected cells acting as "Trojan horses" not only protect bacteria from antibiotic therapies and immune clearance, but also increase the dissemination of pathogens initial sites infection. Antibiotics are hard insufficient to treat such hidden internalized bacteria, especially multidrug-resistant (MDR) bacteria. Herein, aggregation-induced emission luminogens (AIEgens) N,N-diphenyl-4-(7-(pyridin-4-yl) benzo [c] [1,2,5] thiadiazol-4-yl) aniline functionalized with 1-bromoethane...
Abstract Antibiotic therapy and host cells frequently fail to eliminate invasive bacterial pathogens due the emergence of antibiotic resistance, resulting in relapse recurrence infections. Bacteria evolve various strategies persist survive epithelial cells, a front‐line barrier tissues counteracting invasion; however, it remains unclear how bacteria hijack cellular responses promote cytoplasmic survival under therapy. Here, is demonstrated that extracellular show behavior both vivo vitro...
Bacillus cereus is an opportunistic foodborne agent causing food poisoning and many infectious diseases. The heat-stable emetic toxin cereulide one of the most prevalent toxins produced by pathogenic B. cereus, resulting in symptoms such as emesis liver failure. In present work, toxicity toxicokinetics from isolate (CAU45) raw milk were evaluated. production was tested a cytotoxicity test enzyme immunoassay, confirmed presence ces (cereulide synthetase) gene ultra-performance liquid...
Bacillus cereus is an important opportunistic foodborne pathogen. In the present work, a total of 306 milk and environmental samples were collected from 10 local dairy farms in Beijing, China. Of 92 B. cereus-like isolates, 88 4 belonged to thuringiensis, respectively. The prevalence isolates bedding, feces, feed, liquid manure raw was 93.3%, 78.9%, 41.2%, 100.0% 9.8%, Three main toxin genes nhe, hbl ces detected with rates 100.0%, 78.3% 1.1%, but no strain harbored cytK1 production Nhe, Hbl...
Cells living in geometrically confined microenvironments are ubiquitous various physiological processes, e.g., wound closure. However, it remains unclear whether and how spatially geometric constraints on host cells regulate bacteria-host interactions. Here, we reveal that interactions between bacteria constrained cell monolayers exhibit strong spatial heterogeneity, tend to adhere these near the outer edges of monolayers. The bacterial adhesion force micropatterned is up 75 nN, which ~3...
Bacillus cereus is an opportunistic pathogen that often causes foodborne infectious diseases and food poisoning. Non-hemolytic enterotoxin (Nhe) the major toxin found in almost all enteropathogenic B. thuringiensis isolates. However, little known about cellular response after Nhe triggered pore formation on cell membrane. Here, we demonstrate induced cycle arrest at G0 /G1 phase provoked apoptosis Vero cells, most likely associated with mitogen-activated protein kinase (MAPK) death receptor...
Gut microbiota is critical as either the maker of risk or contributor therapy on bacterial infection. Both traditional Chinese medicine compound, Pulsatilla Decoction (PD) and antibiotic, Levofloxacin Hydrochloride (LVX) have antibacterial activity. However, how changes gut after PD LVX treatment hitherto not explicated. Herein, we aim to compare Escherichia coli induced Results showed that exhibited a valid therapeutic approach for E. infection, which also an intestinal protection had less...
The rapid emergence of bacterial coinfection caused by cytosolic bacteria has become a huge threat to public health worldwide. Past efforts have been devoted discover the broad-spectrum antibiotics, while antibiotic resistance encourages development antibacterial agents. In essence, virulence is factor in tolerance. However, discovery and new drugs special antitoxin much more difficult era. Herein, we hypothesize that hemolytic activity can serve as screening principle select combat from...
Migration of neutrophils across endothelial barriers to capture and eliminate bacteria is served as the first line innate immunity. Bacterial virulence factors damage endothelium produce inflammatory cytokines interacts with neutrophils. However, mechanisms that behind endothelial-neutrophil interaction impact on bactericidal activity remain unclear. Therefore, we aimed find target proteins cells triggered transendothelial Herein, built infected models rats co-cultural system (Transwell)...
Natural plant herbs have many active compounds to prevent poultry diseases and improve products. However, most are supplied for human medicine. Thus, economic sustainable development purposes, the dregs of
The emergence and dissemination of bacterial infections is paralyzing our public health systems worldwide. Worse still, there are no effective antibiotics against toxins, which facilitate the infection. Natural herbs that target toxins may be a better choice for therapy infectious diseases. However, most natural drugs present unknown compositions unclear mechanisms. Here we demonstrated Chinese herb Paeoniae Radix aqueous extract (PRAE) could suppress alpha-toxin (α-toxin) Staphylococcus...
The endothelial barrier plays a critical role in immune defense against bacterial infection. Efficient interactions between neutrophils and cells facilitate the activation of both cell types. However, neutrophil can have dual effects, promoting clearance on one hand while triggering inflammation other. In this review, we provide detailed overview cellular progression when encounter bacteria, focusing specifically neutrophil–endothelial or dysfunction. By elucidating underlying mechanisms...
Mechanical properties of tumor cytoskeleton are extremely vital for any phases cancer, especially in invasion and metastasis. However, current category anticancer drugs, the cytoskeleton-targeting drugs limited its role progression is unclear. Here, we present mechanical characteristics stiffness tightly regulated by cancer including actin filaments microtubule during initiation, growth metastasis, review natural that target cytoskeleton. We define dynamics as mechanisms drug, summary plant,...
Abstract Background Gallibacterium anatis , is a gram-negative coccoba-cillus that belong to the family of Pasteurellaceae . It historically considered an opportunistic pathogen intensively reared poultry and domestic birds. main cause salpingitis, ovaritis peritonitis. G. infection lead egg yield quality laying hens will be reduced after infection. has seriously affected overall productivity world industry caused economic losses in industry. Case presentation Herein, we reported this can...