A5076147920- Cardiovascular Issues in Pregnancy
- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Congenital Diaphragmatic Hernia Studies
- Cardiac tumors and thrombi
- Pregnancy and preeclampsia studies
- Cardiac Valve Diseases and Treatments
- Pulmonary Hypertension Research and Treatments
- Neuroendocrine regulation and behavior
- Nicotinic Acetylcholine Receptors Study
- Trauma Management and Diagnosis
- Congenital Anomalies and Fetal Surgery
- Tracheal and airway disorders
- Health disparities and outcomes
- Mercury impact and mitigation studies
- Noise Effects and Management
- Maternal and fetal healthcare
- RNA modifications and cancer
- Cardiac Arrhythmias and Treatments
- Heavy Metal Exposure and Toxicity
- Urban Green Space and Health
- Maternal Mental Health During Pregnancy and Postpartum
- Obstructive Sleep Apnea Research
- Climate Change and Health Impacts
- Biotin and Related Studies
Guangdong Academy of Medical Sciences
2017-2024
Guangdong Provincial People's Hospital
2020-2024
Southern Medical University
2023-2024
Karamay Central Hospital
2024
Guangdong General Hospital
2017-2019
Sina (China)
2010
Peking Union Medical College Hospital
2003
Chinese Academy of Medical Sciences & Peking Union Medical College
2003
Prenatal exposure to toxic trace elements, including heavy metals, is an important public health concern. Few studies have assessed if individual and multiple elements simultaneously affect cardiac development. The current study evaluated the association between maternal blood lead (Pb), cadmium (Cd), chromium (Cr), copper (Cu), mercury (Hg), selenium (Se) levels congenital heart defects (CHDs) in offspring. This hospital-based case-control included 112 case 107 control infants. Maternal...
Accumulating evidence suggests that environmental pollutants may contribute to the occurrence of congenital heart defects (CHDs). However, no previous studies have evaluated impact perfluoroalkyl substances (PFAS), persistent pollutants, on CHDs. This exploratory study aimed generate testable hypotheses association between gestational PFAS and risk A nested case-control was conducted in a cohort 11,578 newborns. Exposure odds ratios were compared 158 CHD cases non-malformed controls...
Objective: Congenital heart diseases (CHDs) are associated with an extremely heavy global disease burden as the most common category of birth defects. Genetic and environmental factors have been identified risk CHDs previously. However, high volume clinical indicators never considered when predicting CHDs. This study aimed to predict occurrence by considering thousands variables from self-reported questionnaires routinely collected laboratory data using machine learning algorithms. Methods:...
Insomnia is common during pregnancy but the prevalence and risk factors of insomnia in Chinese women not well studied. This study aimed to examine its pregnancy. In this cross sectional study, 436 pregnant with Severity Index (ISI) ≥ 8 were clinically assessed using criteria based on combination DSM-IV (Diagnostic Statistical Manual-4th Edition) ICD-10 (International Classification Dieases, 10th Edition). Beck Depression Inventory (BDI), State-Trait Anxiety (STAI), Dysfunctional Beliefs...
Studies focused on pregnant women with congenital heart disease (CHD)-associated pulmonary hypertension (PH) are scarce and limited by small sample sizes single-center design. This study sought to describe the pregnancy outcomes in CHD without PH.
Microbiota especially Bifidobacterium play an important role in adjusting and maintaining homeostatic balance within the infant intestine. The aim of this study was to elucidate relationship between maternal gut microbiota identify species that may transfer from mother over first 42 days infant's life. Nineteen mother-infant-pair fecal samples were collected diversity composition total bacterial communities analyzed via 16S rDNA bifidobacterial groEL gene high throughput sequencing. results...
Certain pregnant women suffer from cardiac pathology,and a few of them need operations under cardiopulmonary bypass during pregnancy. Feto-neonatal and maternal outcomes have not been sufficiently described.We conducted retrospective review 22 cases undergoing pregnancy in our hospital Jan.2014 to Mar.2019.All patients were alive after treatment. The types disorders included congenital heart defects, rheumatic disease,infective endocarditis,aortic dissection, obstruction and/or thrombosis...
Importance The association of folate supplementation with congenital heart disease (CHD) prevention is controversial. Objective To examine the maternal serum levels at early to midpregnancy CHD risk in offspring. Design, Setting, and Participants This case-control study recruited participants from one China’s largest cardiac referral centers between 2015 2018. cases non-CHD controls were matched according age a ratio 1:4. Data analyzed May August 2023. Exposures Maternal folate, vitamin B 12...
Proximity to greenness has shown protective effects on coronary heart diseases by limiting exposure environmental hazards, encouraging physical activity, and reducing mental stress. However, no studies have previously evaluated the impacts of congenital defects (CHDs). We examined association between maternal residential risks CHDs.We conducted a case-control study (8042 children with major CHDs 6887 controls without malformations) in 21 cities Southern China, 2004 - 2016. cases were...
This study aimed to investigate the role and regulatory mechanism of small nucleolar RNA host gene 6 (SNHG6), a long noncoding RNA, in formation ventricular septal defect (VSD). The expression SNHG6 fetal cardiac tissues with VSD, mouse heart embryo development differentiation P19 cells into cardiomyocytes were determined. Moreover, effect aberrant on cell proliferation, cycle, apoptosis was further analyzed explore affecting myocardial development. Furthermore, between miR-101 as well...
Abstract Background Left atrial myxoma during pregnancy is rare. We present three cases in order to aid the management. Case Presentation Three of left were presented this article. patients all received multidisciplinary team work and acquired good outcomes. The case 1 had no symptoms delivered before traditional cardiac surgery. 2 3 undergone totally endoscopic minimally invasive surgery pregnancy. maintained term gave birth a healthy baby via vaginal delivery. No relapse tumor was...
Abstract Smoke exposure during pregnancy has detrimental effects upon numerous fetal and neonatal outcomes. Nicotine (the main component of tobacco) been suggested to affect placental development. During development, efficient invasion by trophoblasts is required for establishment the fetus–maternal circulation. In this study we explored regulation trophoblast nicotine. An immortalized first trimester extravillous cell line (HTR-8/SVneo cells) was used all experiments, which were treated...
Abstract Background While the maternal risk factors on congenital heart defects (CHDs) have often been assessed, paternal contribution to CHDs, especially joint effects of CHDs remain unknown. This study examined major impacts alcohol consumption and its interaction (on multiplicative additive scales) with socioeconomic status (SES) environmental exposures in China. Methods A population‐based case–control involving 4,726 singleton cases controls (without any malformation matched hospital,...
Pulmonary stenosis (PS) is a congenital heart disease characterized by dynamic or fixed anatomic obstruction of blood flow from the right ventricle to pulmonary arterial vasculature. In present study, extracellular vesicle long RNAs (EVLRs) pregnant females who had healthy infants PS were analyzed RNA sequencing, and their diagnostic potential for during pregnancy was evaluated. A method selection genes that could be considered as informative prediction based on vesicles (EVs) using...
The aim of this study was to explore perinatal and early postnatal outcomes in fetuses with prenatally diagnosed d-transposition the great arteries impacts standardised prenatal consultation.All prospectively enrolled at South China cardiac centre from 2011 2015. Standardised consultation introduced 2013 comprehensive measures were implemented, such as establishing fetal CHD Outpatient Consultation Service, performing standard according specifications, a multidisciplinary team senior...
Objectives: Two cases who underwent fetal pulmonary valvuloplasty (FPV) for atresia with intact ventricular septum (PA-IVS) or critical stenosis (CPS-IVS) successfully were reported. The aim of the report was to explore criteria case selection, technical essentials FPV, and postpartum outcome fetus. Methods: One PA-IVS other CPS-IVS enrolled in September 2016 February 2017 Guangdong General Hospital, both diagnosed severe right dysplasia tricuspid regurgitation by echocardiogram. Parameters...
Abstract Background Perioperative management and cardiac surgery in pregnant women with anti-phospholipid syndrome combined heart valve disease have been rarely reported. Case presentation We describe a case of transcatheter mitral valve-in-valve replacement woman bioprosthetic failure at 18 weeks’ gestation. The patient underwent cesarean section delivery 34 weeks gestation, resulting the birth healthy baby. Conclusions Transapical resulted safe maternal infant outcomes failure. success...
A totally endoscopic minimally invasive approach is widely used for cardiac valve surgery in normal adults. However, during pregnancy rarely reported. In addition to traditional median thoracotomy, approaches can now be pregnant patients. We describe our experience with (TECVS) pregnancy, which safe both mothers and fetuses.
To summarize the characteristics of pregnant women with critical congenital heart disease, and to explore continuous, integrated, multidisciplinary management for this segment population.
INTRODUCTION The incidence of fetal cardiac tumor was about 0.14% as determined by echocardiography.[1] It extremely difficult to deal with the fetus when severe circulatory instability induced a in womb. reported that ex utero intrapartum treatment (EXIT) procedure solved problems airway or pulmonary lesion during delivery avoid hypoxia after birth.[2] goal EXIT is maintain placental circulation while steps are taken optimize transition baby from neonatal life. This study introduced...