A5022431805- Cancer Mechanisms and Therapy
- Cancer-related molecular mechanisms research
- Gastric Cancer Management and Outcomes
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Colorectal Cancer Surgical Treatments
- Ferroptosis and cancer prognosis
- Metastasis and carcinoma case studies
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Abdominal Surgery and Complications
- Stoma care and complications
- Sirtuins and Resveratrol in Medicine
- Thyroid and Parathyroid Surgery
- Tea Polyphenols and Effects
- Radiation Dose and Imaging
- Toxin Mechanisms and Immunotoxins
- Gastrointestinal Tumor Research and Treatment
- Helicobacter pylori-related gastroenterology studies
- Thyroid Cancer Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Pancreatitis Pathology and Treatment
- Epigenetics and DNA Methylation
- Medical and Biological Ozone Research
- Titanium Alloys Microstructure and Properties
Shandong Provincial Hospital
2020-2024
Shandong First Medical University
2022-2024
Shandong University
2020-2024
Children's Hospital
2023
Qilu Hospital of Shandong University
2023
Shandong University of Traditional Chinese Medicine
2022
Peking University
2013-2017
Peking University People's Hospital
2014-2017
Beijing Administration Institute
2015
Qingdao University
2012-2014
Tumor growth cascade is a complicated and multistep process with numerous obstacles. Until recently, evidences have shown the involvement of microRNAs (miRNAs) in tumorigenesis tumor progression various cancers, including colorectal cancer (CRC). In this study, we explored role miR-194 its downstream pathway CRC. We acquired data through miRNA microarray profiles, showing that expression was significantly suppressed CRC tissues compared corresponding noncancerous tissues. Decreased obviously...
The progression of distant metastasis cascade is a multistep and complicated process, frequently leading to poor prognosis in cancer patients. Recently, growing evidence has indicated that deregulation microRNAs (miRNAs) contributes tumorigenesis tumor colorectal (CRC). In the present study, by comparing miRNA expression profiles CRC tissues corresponding hepatic tissues, we established downregulation miR-199b tissues. decrease was significantly correlated late TNM stage metastasis....
Recent studies have indicated the possible function of miR-217 in tumorigenesis. However, roles colorectal cancer (CRC) are still largely unknown. We examined expression and AEG-1 50 CRC tissues corresponding noncancerous by qRT-PCR. The clinical significance was analyzed. cell lines with upregulation silencing were established effects on tumor growth vitro vivo assessed. Dual-luciferase reporter gene assays also performed to investigate interaction between AEG-1. Our data demonstrated that...
Colorectal cancer (CRC) is the third most common worldwide and its treatment remains a challenge. Effective control of cell survival proliferation critical in prevention oncogenesis successful cancer. Long non-coding RNAs (lncRNAs) have emerged as primary regulators carcinogenesis. Growth arrest specific 5 (GAS5), lncRNA, known to be aberrantly expressed several types cancer, however, role GAS5 CRC unclear. In present study, mRNA expression was measured adjacent normal mucosa tissue samples...
Aberrantly expressed microRNAs (miRNAs) are frequently correlated with a variety of human cancers, including clear cell renal carcinoma (ccRCC).In this study, we determined the expression patterns miR-217 in ccRCC, and tested its effect on cancer proliferation migration.The levels were 54 ccRCC samples using Real-Time qPCR.786-O ACHN cells transfected mimics or miRNA control.Cell migration evaluated by MTT assay scratch-wound assay, respectively.We found that was down-regulated compared to...
Although genome-wide association studies have identified many risk loci associated with colorectal cancer, the molecular basis of these associations are still unclear. We aimed to infer biological insights and highlight candidate genes interest within GWAS loci. used an in silico pipeline based on functional annotation, quantitative trait mapping cis-acting gene, PubMed text-mining, protein-protein interaction studies, genetic overlaps cancer somatic mutations knockout mouse phenotypes,...
To evaluate the prognostic significance of seventh edition TNM staging classification for gastric cancer.The system cancer was adopted by American Joint Committee on Cancer/International Union Against Cancer January 1, 2010, and included major revisions.The authors analyzed data retrospectively collected patients with who underwent surgery at Affiliated Hospital Qingdao University Medical College between 2000 2008. A total 964 R0 surgical resection were included.The relative risk (RR) T...
Background Sirtuin 1 (SIRT1) has been reported to have diverse roles in various biological processes through deacetylation of histone and nonhistone proteins. However, the correlations among SIRT1 protein expression, clinicopathological parameters, survival colorectal cancer patients remain unclear. Methods expression was measured by immunohistochemistry a paraffin-embedded tissue microarray, including 120 paired normal mucosa tissues. The features, prognosis were analyzed. Results All...
Abstract Background Protective loop ileostomy is commonly performed in laparoscopic low anterior rectal resection to prevent the serious complications of anastomotic fistula. It usually created at right lower quadrant abdomen and another wound required for stoma. The study aimed evaluate outcomes specimen extraction site (SES) (AS) beside auxiliary incision. Methods A retrospective analysis was conducted on 101 eligible patients with pathologically diagnosed adenocarcinoma rectum from...
Abstract Integrative expression Quantitative Trait Loci (eQTL) analysis found that rs8180040 was significantly associated with Coiled-coil domain containing 12 ( CCDC12 ) in colon adenocarcinoma (COAD) patients. Immunohistochemical staining and western blotting confirmed highly expressed COAD tissues, which consistent RNA-Seq data from the TCGA database. Knockdown of could reduce proliferation, migration, invasion, tumorigenicity cancer cells, while exogenous overexpression had opposite...
The treatment of gastric cancer (GC) is extremely challenging; however, the specific pathogenesis GC remains unclear. Circular RNAs (CircRNAs) are non-coding that can regulate gene expression both transcriptionally and post-transcriptionally. However, little known about circRNAs important in progression GC. This study identified significantly dysregulated by analyzing patients normal control tissues. target was predicted using online bioinformatics tools verified RNA pull-down luciferase...
Genome-wide association studies of colorectal cancer (CRC) have identified two risk SNPs.The characterization these regions in diverse racial groups with different linkage disequilibrium structure would aid localizing the causal variants.Herein, fine mapping established CRC loci was carried out 1,508 cases and 1,482 controls obtained from Han Chinese population.One distinct signal at loci, where implicated rs1010208 as a functional locus.Next, candidate target genes SNP were analyzed using...
Genome-wide association studies have identified many risk loci associated with colorectal cancer. Strategies integrating biological data sets GWAS results will provide insights into the roles of single-nucleotide polymorphisms. We performed expression quantitative trait locus-based analyses using information provided in The Cancer Genome Atlas. Analysis cis-expression (eQTLs) 18 previously reported cancer resulted discovery five variants that were significantly gene expressions. trans-eQTLs...
Fibroblast growth factor receptor-like-1 (FGFRL1) is important to cell motility and links with tumorigenic potential in various types of cancers. To investigate the biological function underlying mechanism FGFRL1 rectal adenocarcinoma, we conducted this study. TCGA Oncomine databases were used analyze expression its association clinical characteristics or overall survival (OS) adenocarcinoma patients. siRNA strategy was implemented knockdown cells. CCK8, colony formation, wound healing,...
Objective To investigate the clinical significance and risk factors of hyperamylasemia after laparoscopic gastrointestinal operation.Methods In this study 200 patients undergoing surgery between March 2011 July 2012 were divided into two groups based on serum amylase level.The postoperative complications observed.Hyperamlasemia was defined as more than 110 IU/L.Factors related with selected t-test,chi-square test used for univariate analysis.Statistically significant variables multivariate...