A5041763919- Fibromyalgia and Chronic Fatigue Syndrome Research
- Olfactory and Sensory Function Studies
- Psychosomatic Disorders and Their Treatments
- Mental Health Research Topics
- Autism Spectrum Disorder Research
- Neural dynamics and brain function
- Spatial Cognition and Navigation
- Multisensory perception and integration
- Stress Responses and Cortisol
- Bipolar Disorder and Treatment
- Schizophrenia research and treatment
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Functional Brain Connectivity Studies
- Memory and Neural Mechanisms
- Musculoskeletal pain and rehabilitation
- Neurological disorders and treatments
- Advanced MRI Techniques and Applications
- Neural and Behavioral Psychology Studies
- Neuroscience and Neuropharmacology Research
- Neurobiology and Insect Physiology Research
- Color perception and design
- Empathy and Medical Education
- Treatment of Major Depression
- Mental Health and Psychiatry
- Biochemical Analysis and Sensing Techniques
Newcastle University
2011-2019
Newcastle Hospitals - Campus for Ageing and Vitality
2014-2019
Cellular Therapeutics (United Kingdom)
2016-2018
The Neurosciences Foundation
2016
UF Health Shands Hospital
2015
Cumbria Northumberland Tyne and Wear NHS Foundation Trust
2015
Jülich Aachen Research Alliance
2008-2014
RWTH Aachen University
2008-2014
Brain (Germany)
2010-2012
Forschungszentrum Jülich
2012
Insights from both lesion and neuroimaging studies increasingly substantiate the view that human cerebellum not only serves motor control but also supports various cognitive processes. Higher functions like working memory or executive have been associated with phylogenetically younger parts of cerebellum, crus I II. Functional connectivity corroborate this notion as activation correlates activity in numerous areas cerebral cortex. Moreover, these cerebrocerebellar loops were shown to be...
Facial expressions, prosody, and speech content constitute channels by which information is exchanged. Little known about the simultaneous differential contribution of these to empathy when they provide emotionality or neutrality. Especially neutralised has gained little attention with regards influencing perception other emotional cues.Participants were presented video clips actors telling short-stories. One condition conveyed in all while conditions either provided neutral content, facial...
Object recognition benefits maximally from multimodal sensory input when stimulus presentation is noisy, or degraded. Whether this advantage can be attributed specifically to the extent of overlap in object-related information, rather, object-unspecific enhancement due mere presence additional stimulation, remains unclear. Further, cortical processing differences driving increased multisensory integration (MSI) for degraded compared with clear information remain poorly understood. Here, two...
Investigate global and regional grey white matter volumes in patients with Chronic Fatigue Syndrome (CFS) using magnetic resonance imaging (MRI) recent voxel-based morphometry (VBM) methods. Forty-two CFS thirty healthy volunteers were scanned on a 3-Tesla MRI scanner. Anatomical scans segmented, normalized submitted to VBM analysis randomisation Group differences identified overall segment voxel-wise spatially (GM) (WM) segments. Accounting for total intracranial volume, had larger GM...
Background. Attentional impairment is a core cognitive feature of major depressive disorder (MDD) and bipolar (BD). However, little known the characteristics response time (RT) distributions from attentional tasks. This crucial to furthering our understanding profile extent intra-individual variability (IIV) in mood disorders. Method. A computerized sustained attention task was administered 138 healthy controls 158 patients with disorder: 86 euthymic BD, 33 depressed BD 39 medication-free...
Cognitive task demands in one sensory modality (T1) can have beneficial effects on a secondary (T2) different modality, due to reduced top-down control needed inhibit the task, as well crossmodal spread of attention. This contrasts findings cognitive load compromising modality's processing. We manipulated within (visual) and studied consequences (auditory) 15 healthy participants underwent simultaneous EEG-fMRI experiment. Data from 8 were obtained outside scanner for validation purposes....
Humans tend to have a positive self-evaluation (PSE). To what extent self-perception is interacting with valenced self-related memories debated. The underlying neural substrates are not adequately explained yet. explore the cerebral correlates of PSE and its influence on memory, 24 healthy subjects were asked during fMRI decide in two conditions whether presented negative personality traits characterized their own selves (self-evaluation) or an intimate other (other-evaluation). A lexical...
Objectives To explore cognitive performance in chronic fatigue syndrome (CFS) examining two cohorts. establish findings associated with CFS and those related to co-morbid depression or autonomic dysfunction. Methods Identification recruitment of participants was identical both phases, all patients fulfilled Fukuda criteria. In Phase 1 (n = 48) we explored function a heterogeneous cohort patients, investigating links depressive symptoms (HADS). phase 2 51 & n 20 controls) major were excluded...
Autistic spectrum disorder (ASD) is diagnosed on the basis of impairment in reciprocal social interaction and language, rigidity behavior. This brief paper describes development an experimental intervention for preschool children newly with ASD. The rationale this hypothesis that failure to attend cues very early life, itself, may bear a large share responsibility core communicative deficits. intervention, therefore, uses eye-tracking monitor trigger rewards attention facial expression...
Empathy is a basic human ability, and patients with schizophrenia show dysfunctional empathic abilities on the behavioural neural level.These dysfunctions may precede onset of illness; thus, it seems mandatory to examine in individuals at clinical high risk for psychosis.Using functional magnetic resonance imaging, we measured 15 psychosis (CHR group) compared their empathy performance healthy volunteers schizophrenia.Behavioural data analysis indicated no significant deficit CHR group....
Background Childhood maltreatment is one of the strongest predictors adulthood depression and alterations to circulating levels inflammatory markers putative mechanism mediating risk or resilience. Aims To determine effects childhood on 41 in healthy individuals those with a major depressive disorder (MDD) diagnosis. Method We investigated association two groups, 164 patients MDD 301 controls, using multiplex electrochemiluminescence methods applied blood serum. Results was not associated...
Background Navigation based on chemosensory information is one of the most important skills in animal kingdom. Studies odor localization suggest that humans have lost this ability. However, experimental approaches used so far were limited to explicit judgements, which might ignore a residual ability for directional smelling an implicit level without conscious appraisal. Methods A novel cueing paradigm was developed order determine whether exists. Participants performed visual two-alternative...
Objectives To explore potential mechanisms that underpin the cardiac abnormalities seen in chronic fatigue syndrome (CFS) using non-invasive impedance, red cell mass and plasma volume measurements. Methods Cardiac MR (MR) examinations were performed 3 T Philips Intera Achieva scanner (Best, NL) participants with CFS (Fukuda; n=47) matched case-by-case controls. Total (TV), (RCV) (PV) measurements (41 10 controls) indicator dilution technique simultaneous 51-chromium labelling of blood cells...
Importance Chronic fatigue syndrome (CFS) is characterised by a constellation of symptoms diagnosed with number different polythetic criteria. Heterogeneity across these diagnostic criteria likely to be confounding research into the as-yet-unknown pathophysiology underlying this stigmatised and debilitating condition may diagnose disease spectrum significant implications for clinical management. No studies date have objectively investigated possibility using validated measure CFS...
Due to the unique neural projections of olfactory system, odours have ability directly influence affective processes. Furthermore, it has been shown that emotional states can various non-emotional cognitive tasks, such as memory and planning. However, link between processes is still not fully understood. The present study used pathway induce a negative state in humans investigate its effect on inhibitory control performance standard, single-trial manual Stroop colour-word interference task....
Symptoms of orthostatic intolerance (OI) are common in Chronic Fatigue Syndrome (CFS) and similar disorders. These symptoms may relate to individual differences intracranial compliance cerebral blood perfusion. The present study used phase-contrast, quantitative flow magnetic resonance imaging (MRI) determine based on arterial inflow, venous outflow cerebrospinal fluid along the spinal canal into out cranial cavity. Flow-sensitive Alternating Inversion Recovery (FAIR) Arterial Spin Labelling...