A5087194097- Childhood Cancer Survivors' Quality of Life
- Bone health and treatments
- Cancer Risks and Factors
- Ocular Oncology and Treatments
- Acute Lymphoblastic Leukemia research
- Glioma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Bone Metabolism and Diseases
- Iron Metabolism and Disorders
- Neuroblastoma Research and Treatments
- Hemoglobinopathies and Related Disorders
- Pharmacological Effects and Toxicity Studies
- Ethics and Legal Issues in Pediatric Healthcare
- Blood disorders and treatments
- Metabolism, Diabetes, and Cancer
- Global Cancer Incidence and Screening
- BRCA gene mutations in cancer
- Acute Myeloid Leukemia Research
- Colorectal Cancer Screening and Detection
- Vitamin D Research Studies
- Data-Driven Disease Surveillance
- Neutropenia and Cancer Infections
- CAR-T cell therapy research
- Bone Tumor Diagnosis and Treatments
- Bone health and osteoporosis research
Essen University Hospital
2010-2025
Zentrum für Kinderheilkunde
2016-2025
University of Duisburg-Essen
2014-2024
Heidelberg University
2016
University Hospital Heidelberg
2016
Abstract Background Survivors of heritable retinoblastoma carry a high risk to develop second cancers. Eye‐preserving radiotherapy raises this risk, while the impact chemotherapy remains less defined. Procedure This population‐based study characterizes all treatment modalities on cancers incidence and type after in Germany. Data cancer 648 patients with treated between 1940 2008 at German national reference center for were analyzed identify associations treatment. Results The cumulative...
Background Familial hemophagocytic lymphohistiocytosis is a genetic disorder of lymphocyte cytotoxicity that usually presents in the first two years life and has poor prognosis unless treated by hematopoietic stem cell transplantation. Atypical courses with later onset prolonged survival have been described, but no detailed analysis immunological parameters associated typical versus atypical forms familial performed.Design Methods We analyzed disease manifestations, NK-cell T-cell...
Juvenile Paget's disease (JPD) is an extremely rare, yet painful and debilitating bone with onset occurring during early childhood. JPD can be caused by loss of function osteoprotegerin, resulting in subsequent stimulation osteoclasts via the receptor activator nuclear factor-κB (RANK) pathway. Increased turnover lack modeling lead to severe deformities, frequent fractures, short stature, hearing.The treatment for challenging has previously been based on administration either calcitonin or...
Einleitung: Die Brentuximab Vedotin (BV) vermittelte Antikörper (AK)-Behandlung (CD30) ist zur Rezidivtherapie nach autologer Stammzelltransplantation (ASCT) für das Hodgkin Lymphom (HG) zugelassen. 2/3 der Patienten entwickeln hierbei eine reversible periphere Neuropathie (PN). Myositis als mögliche NW wurde bisher nicht berichtet.
Purpose Intraocular retinoblastoma is curable, but survivors with a heritable predisposition are at high risk for second malignancies. Because malignancies associated mortality, prognostic factors malignancy influence long-term overall survival. This study investigates the impact of all types eye-preserving therapies on survival in complete German cohort patients retinoblastoma. Patients and Methods Overall survival, disease staging using international scales, time period diagnosis,...
Introduction Suspected osteopathology in chronically ill children often necessitates the assessment of bone mineral density. The most frequently used methods are dual-energy X-ray-absorption (DXA) and peripheral quantitative computed tomography (pQCT). BoneXpert software provides an automated radiogrammatic method to assess skeletal age from digitalized X-rays left hand. Furthermore, program calculates Bone Health Index (BHI), a measure cortical thickness mineralization, which is obtained...
Background: About one quarter of children affected with cancer die. For and their families, the end-of-life period is highly distressing. Aim: This study focused on how care in pediatric patients changed over a 10 years if changes palliative structures were associated quality care. Design: Over 10-year period, all oncology departments German federal state invited to participate repeated cross-sectional cohort at three time-points (2005, 2010, 2015). Departments parents whose died due 5...
Abstract Purpose The transition process from paediatric/adolescent to adult medical care settings is of utmost importance for the future health adolescents with chronic diseases and poses even more difficulties in context rare (RDs). Paediatric teams are challenged deliver adolescent-appropriate information structures. Here we present a structured pathway which patient-focused adoptable different RDs. Methods 16 years older was developed implemented as part multi-centre study 10 university...
Preeclampsia, a hypertensive disorder in pregnancy develops 2-8% of pregnancies worldwide. Winter season and vitamin D deficiency have been associated with its onset.To investigate the influence on maternal status placental metabolism.25-OH 1,25-(OH)2 were measured serum obtained during winter or summer months from 63 pregnant women at delivery (43 healthy, 20 preeclampsia). In subgroup, mRNA expression CYP24A1 (24-hydroxylase), CYP27B1 (1α-hydroxylase) VDR (vitamin receptor) quantified by...
Intraventricular cerebral hemorrhage (IVH) is one of the most severe complications premature birth, potentially leading to lifelong disability. The purpose this paper assessment evolution three relevant parameters, before and after IVH: mean arterial pressure (MAP), carbon dioxide (pCO
Ex vivo expansion of human CD34+ hematopoietic stem and progenitor cells remains a challenge due to rapid differentiation after detachment from the bone marrow niche. In this study, we assessed capacity an inducible fusion protein enable sustained ex proliferation precursors their differentiate into functional phagocytes. We fused coding sequences FK506-Binding Protein 12 (FKBP12)-derived destabilization domain (DD) myeloid/lymphoid lineage leukemia/eleven nineteen leukemia (MLL-ENL) gene...
Introduction Sickle cell anemia and thalassemia result in impaired bone health both adults youths. Children with other types of chronic hemolytic may also display health. Study Design To assess pediatric patients anemia, a cross-sectional study was conducted involving 45 different forms (i.e., 17 homozygous sickle disease 14 hereditary spherocytosis patients). Biochemical, radiographic anamnestic parameters were assessed. Results Vitamin D deficiency 25 OH-vitamin serum levels below 20 ng/ml...
Survivors of childhood cancer frequently suffer from endocrine late effects, which are, at least partly, attributed to toxic effects chemotherapy. Treatment retinoblastoma typically involves chemotherapy a very young age. The authors conducted cross-sectional study assess bone health in pediatric cohort 33 survivors (mean age: 4.4 years) who had undergone treatment an especially age 0.76 years). Of these patients, 14 unilateral and 19 bilateral retinoblastoma. Polychemotherapy consisted with...
Abstract Introduction: Juvenile Paget’s disease (JPD), an ultra-rare, debilitating bone due to loss of functional osteoprotegerin (OPG), is caused by recessive mutations in TNFRFSF11B. A genotype–phenotype correlation spanning from mild very severe forms described. Aim: This study aimed describe the complexity human phenotype OPG deficiency more detail and investigate heterozygous mutation carriers for clinical signs JPD. Patients: We investigated 3 children with JPD families Turkish,...
Childhood cancer entails a heavy burden for patients and their families. Recent advances in overall survival rates have increasingly brought long-term quality of life into focus. Animal-assisted activities (AAAs) long been hypothesized to alleviate the on pediatric peers hospital setting. However, use inpatient oncology has sensitive issue mainly due fear infections, resulting lack studies. This study presents data feasibility, safety, efficacy AAAs from single German center.
We report a 26-month-old female who developed port-site metastases of neuroblastoma following minimally invasive thoracoscopic interventions. After diagnosis an intrathoracic low-risk and 6 months observation, she respiratory problems. She subsequently underwent total resection locally progressive tumor via thoracoscopy. Six later, local relapse subcutaneous within the thoracic wall. These were most likely iatrogenic. excision metastases, residual responded well to salvage chemotherapy. The...
Background: Impaired bone health is a late effect of childhood malignancies which can be difficult to detect in juvenile survivors. It may, however, lead compromised quality life, or even permanent disability later life due osteoporosis, pain fractures if left untreated. Acute lymphoblastic leukemia (ALL) the most frequent malignancy with an over 85% five-year survival. ALL and its treatment cause alterations adults, but little information on status survivors available. Objective: To report...
Abstract Biallelic germline mutations in BRCA2 occur the Fanconi anemia (FA)-D1 subtype of rare pediatric disorder, FA, characterized clinically by severe congenital abnormalities and a very high propensity to develop malignancies early life. Clinical genetic data from 96 FA-D1 patients with biallelic were collected used new cancer risk prediction score system based on specific BRCA2. This takes into account location frameshift/stop missense relative exon 11 BRCA2, which encodes major sites...
Little is known regarding bone marrow (BM) cellularity, CD34+ fraction, and CFU-GM colony formation in relation to age whether healthy children require a reference range distinct from adults. We therefore analyzed series of single BM aspirates 45 who were evaluated as potential donors. Thirty-three these subsequently donated BM. quantified the nucleated cell count, fraction cells, number colonies harvests. Single displayed mean count 31.3 × 106 cells/mL, 1.17% forming 66.6 CFU-GM/105 cells....
Animal models have shown that the skeletal hormone osteocalcin stimulates testicular testosterone synthesis. To assess whether might be a useful marker to detect pubertal development disorders, we examined plasma concentrations in children and adolescents with without disorders of development.Osteocalcin were investigated total 244 patients endocrine (122 males, mean age: 11.87+3.77 years), including precocious puberty constitutional delay puberty.Osteocalcin highest among advanced...
Metamizole is a widely prescribed NSAID with excellent analgesic and antipyretic properties. Although very effective, it banned in some countries because of the risk for severe agranulocytosis. We here describe three patients metamizole-associated Patient #1 suffered from agranulocytosis tonsillitis followed by sepsis Streptococcus pneumoniae Epstein–Barr virus reactivation. Her dizygotic twin sister (patient #2) also after surgical intervention. #3 initially had developed neutropenia...