A5060605323- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Adipokines, Inflammation, and Metabolic Diseases
- Vehicle emissions and performance
- Endoplasmic Reticulum Stress and Disease
- Toxic Organic Pollutants Impact
- Peroxisome Proliferator-Activated Receptors
- Diabetes and associated disorders
- Atmospheric chemistry and aerosols
- Air Quality and Health Impacts
- Metabolism, Diabetes, and Cancer
- Liver physiology and pathology
- Metabolomics and Mass Spectrometry Studies
- Liver Disease Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Technology and Human Factors in Education and Health
- Advanced Control and Stabilization in Aerospace Systems
- Machine Learning in Bioinformatics
- Hormonal Regulation and Hypertension
- IL-33, ST2, and ILC Pathways
- Cardiac Health and Mental Health
- Aviation Industry Analysis and Trends
- Traffic control and management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Air Traffic Management and Optimization
Central South University
2009-2022
Second Xiangya Hospital of Central South University
2010-2022
Xiamen University
2011-2014
Diabetes Australia
2014
National Clinical Research
2014
National Student Clearinghouse Research Center
2014
ILC2s are present in adipose tissue and play a critical role regulating thermogenesis. However, the mechanisms underlying activation of adipose-resident remain poorly defined. Here, we show that IL-33, potent ILC2 activator, stimulates phosphorylation AMPK at Thr172 via TAK1 primary ILC2s, which provides feedback mechanism to inhibit IL-33-induced NF-κB IL-13 production. Treating with adiponectin or an receptor agonist (AdipoRon) activated decreased IL-33-NF-κB signaling. AdipoRon also...
A dynamically regulated microenvironment, which is mediated by crosstalk between adipocytes and neighboring cells, critical for adipose tissue homeostasis function. However, information on key molecules and/or signaling pathways regulating the remains limited. In this study, we identify adipocyte miRNA-182-5p (miR-182-5p) as a crucial antiobesity molecule that stimulated beige fat thermogenesis promoting macrophages. miR-182-5p was highly enriched in thermogenic adipocytes, its expression...
The growth factor receptor bound protein GRB10 is an imprinted gene product and a key negative regulator of the insulin, IGF1 mTORC1 signaling pathways. highly expressed in mouse fetal liver but almost completely silenced adult mice, suggesting potential detrimental role this function. Here we show that Grb10 could be reactivated by acute endoplasmic reticulum stress (ER stress) such as tunicamycin or short-term high-fat diet (HFD) challenge, concurrently with increased unfolded response...
Hepatic insulin resistance and hepatosteatosis in diet-induced obesity are associated with various metabolic diseases, yet the underlying mechanisms remain to be fully elucidated. Here we show that expression levels of disulfide-bond A oxidoreductase-like protein (DsbA-L) significantly reduced liver obese mice humans. Liver-specific knockout or adenovirus-mediated overexpression DsbA-L exacerbates alleviates, respectively, high-fat diet–induced mitochondrial dysfunction, hepatosteatosis,...
Abstract A unique feature of the liver is its high regenerative capacity, which essential to maintain homeostasis. However, key regulators regeneration (LR) remain ill-defined. Here, we identify hepatic miR-182-5p as a regulator LR. Suppressing miR-182-5p, whose expression significantly induced in mice post two-thirds partial hepatectomy (PH), abrogates PH-induced LR mice. In contrast, liver-specific overexpression promotes with PH. Overexpression failed promote proliferation hepatocytes,...
Type 2 immune response has been shown to facilitate cold-induced thermogenesis and browning of white fat. However, whether alternatively activated macrophages produce catecholamine substantially promote adaptive in adipose tissue remains controversial. Here, we show that tyrosine hydroxylase (TyrH), a rate-limiting enzyme biosynthesis, was expressed phosphorylated adipose-resident macrophages. In addition, the plasma level adrenaline increased by cold stress mice, treatment with stimulated...
Aim Patients with depression have a high prevalence of developing dyslipidemia. In this study, we aim to investigate the difference serum lipids, including total cholesterol (TCH), high-density lipoprotein (HDL-C), low-density (LDL-C), and triglycerides (TG), between depressed patients healthy controls. Sex differences in lipids their psychological correlations were also included.Methods The study included 56 controls (males/females = 26/30) 110 first-diagnosed drug-naïve outpatients 35/75)....
Decreased functional β-cell mass is the hallmark of diabetes, but cause this metabolic defect remains elusive. Here, we show that levels growth factor receptor-bound protein 10 (GRB10), a negative regulator insulin and mTORC1 signaling, are markedly induced in islets diabetic mice high glucose-treated insulinoma cell line INS-1 cells. β-cell-specific knockout Grb10 increased improved function. Grb10-deficient β-cells exhibit enhanced signaling reduced dedifferentiation, which could be...
Objective To investigate the protective effects and potential mechanisms of TZD upon pancreatic β-cells. Methods Apoptosis was induced in vitro by interleukin-1β (IL-1β) interferon-γ (IFN-γ). After treatment with resiglitazoue(RSG)/ pioglitazone (PIG) at final concentrations 1 μmol/L, 10 20 μmol/L respectively, apoptotic rate NIT-1 cells determined Hoechest33342 staining Annexin V-FITC/PI flow cytometry respectively. Caspase-3 specific activity assay insulin secretion measured ELISA. Results...
This paper aims to study the eye fixation and movements of air traffic control (ATC) controllers while working.Based on establishment experimental platform simulation, every behavior feature movement was recorded under different difficulty levels experiments.With geographic coordinates controlled area being converted their corresponding screen coordinates, could be divided into six zones by means clustering analysis.The percentage points per unit in Zones 1 2 is dramatically greater than...