A5061918348- Fungal Biology and Applications
- Asthma and respiratory diseases
- Plant biochemistry and biosynthesis
- Antifungal resistance and susceptibility
- Microbial Natural Products and Biosynthesis
- Plant-Microbe Interactions and Immunity
- Traumatic Brain Injury Research
- Respiratory and Cough-Related Research
- Neonatal Respiratory Health Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Synthesis and Biological Evaluation
- Allergic Rhinitis and Sensitization
- Mycorrhizal Fungi and Plant Interactions
- Psychosomatic Disorders and Their Treatments
- Respiratory viral infections research
- IL-33, ST2, and ILC Pathways
- Probiotics and Fermented Foods
- Restraint-Related Deaths
- Plant Pathogens and Fungal Diseases
- Pediatric health and respiratory diseases
- Fungal and yeast genetics research
University of Wisconsin–Madison
2020-2024
Newcastle University
2017
North Dakota State University
2014
Abstract Filamentous fungi differentiate along complex developmental programs directed by abiotic and biotic signals. Currently, intrinsic signals that govern fungal development remain largely unknown. Here we show an endogenously produced secreted oxylipin, 5,8-diHODE, induces cellular differentiation, including lateral branching in pathogenic Aspergillus fumigatus flavus , appressorium formation the rice blast pathogen Magnaporthe grisea . The response is specific to a subset of oxylipins...
Filamentous fungi produce numerous uncharacterized natural products (NPs) that are often challenging to characterize because of cryptic expression in laboratory conditions. Previously, we have successfully isolated novel NPs by expressing fungal artificial chromosomes (FACs) from a variety species into
Background Aspergillus fumigatus is a well-known opportunistic pathogen that causes range of diseases including the often-fatal disease, invasive pulmonary aspergillosis (IPA), in immunocompromised populations. The severity IPA dependent on both host- and pathogen-derived signaling molecules mediate host immunity fungal growth. Oxylipins are bioactive oxygenated fatty acids known to influence immune response developmental programs. synthesizes 8-HODE 5,8-diHODE have structural similarities...
In studying the development of tolerance to common hospital cleaners (Oxivir® and CaviCide™) in clinical isolate stocks emerging, multidrug-resistant yeast pathogen Candida auris, we selected for a cleaner-tolerant subpopulation more nosocomial pathogen, glabrata. Through purification each species subsequent competition other analyses, determined that C. glabrata is capable readily dominating mixed populations auris when exposed cleaners. This result suggests exposure antimicrobial compounds...
Abstract Filamentous fungi produce numerous uncharacterized natural products (NPs) that are often challenging to characterize due cryptic expression in laboratory conditions. Previously, we have successfully isolated novel NPs by expressing fungal artificial chromosomes (FACs) from a variety of species into Aspergillus nidulans . Here, demonstrate new twist FAC utility wherein heterologous Pseudogymnoascus destructans A. altered endogenous terpene biosynthetic pathways. In contrast wildtype,...