A5100416926- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- Multicomponent Synthesis of Heterocycles
- Synthesis and biological activity
- Glycosylation and Glycoproteins Research
- Reproductive System and Pregnancy
- Radiomics and Machine Learning in Medical Imaging
- Reproductive Physiology in Livestock
- Synthesis of Organic Compounds
- Metalloenzymes and iron-sulfur proteins
- Advanced Breast Cancer Therapies
- Advanced Photocatalysis Techniques
- RNA Interference and Gene Delivery
- Bacteriophages and microbial interactions
- Advanced biosensing and bioanalysis techniques
- Metal-Catalyzed Oxygenation Mechanisms
- Synthesis of heterocyclic compounds
- 2D Materials and Applications
- Photosynthetic Processes and Mechanisms
- Membrane Separation Technologies
- Pregnancy and preeclampsia studies
- Disaster Management and Resilience
- Electrospun Nanofibers in Biomedical Applications
- Carbon and Quantum Dots Applications
- Mesenchymal stem cell research
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2024
Guangzhou University of Chinese Medicine
2020-2024
Incyte (United States)
2019-2023
Sichuan University
2022
Dali University
2014-2021
West China Medical Center of Sichuan University
2021
Forschungszentrum Jülich
2021
Hohai University
2020
Chinese PLA General Hospital
2018
The Ohio State University
2012-2014
The glutathione-coordinated [2Fe-2S] cluster is demonstrated to be a viable and likely substrate for physiological iron-sulfur transport by Atm1p, mitochondrial ABC export protein. Flow cytometry colorimetric assays demonstrate quantitative methodology study of metal translocation proteins their proteoliposome products.
Abstract Stem cell transplantation is a promising therapeutic strategy for myocardial infarction. However, transplanted cells face low survival rates due to oxidative stress and the inflammatory microenvironment in ischemic heart tissue. Melatonin has been used as powerful endogenous antioxidant protect from injury. melatonin cannot play long-lasting effect against hostile microenvironment. Nano drug delivery carriers have ability loaded degradation physiological environments controlled...
Assembly and stabilization of a glutathione-complexed [2Fe-2S] cluster is promoted by aggregation glutathione. The core selects the tetramer species from collection equilibrating solution aggregate species, in turn stabilized toward hydrolytic degradation. Studies glutathione derivatives, combination with mass spectrometric Mössbauer investigations provide insight on reaction intermediates during formation [2Fe-2S](GS)4(2-).
Enhanced blue fluorescent carbon nitride quantum dots (g-C3N4QDs) were synthesized by a simple solvothermal "tailoring" process from bulk g-C3N4 and analyzed various characterization methods. The as-obtained g-C3N4QDs successfully applied in the determination of tetracycline (TC) with good linear relationship range 0.23-202.70 μM. proposed sensor shows excellent stability, repeatability, high selectivity outstanding sensitivity to TC low detection limit 0.19 fluorescence quenching mechanism...
Human ferredoxin-1 (hFd1) and human ferredoxin-2 (hFd2) share high sequence similarity but serve on distinct cellular pathways. A unique conformational change is observed when holo hFd2 warmed to physiological temperatures, or higher. Enzymatic studies show that this causes the increase of affinity between adrenodoxin reductase. No such was for hFd1, which may contribute functions hFd1 under conditions.
Objective . Evidence regarding the relationship between vitamin A and HPV infection was limited. Therefore, this study is designed to investigate whether independently related in 13412 American women from NHANES for seven cycles. Methods The present a cross-sectional study. total of eligible participants who had available tests intake data were registered NHANE database 2003 2016. targeted independent variable dependent measured at baseline infection, respectively. We analyzed association...
Research exploring the link between immune cell profiles and development of endometritis remains scant. This gap necessitates further study to decode complex interrelations influencing this condition. In analysis, we leveraged two-sample Mendelian randomization examine causal ties phenotypes cells incidence endometritis. Our evaluation hinged on data from 3757 participants hailing Sardinia, focusing a diverse array 731 phenotypes, cross-referenced with sourced UK Biobank. To ensure rigor,...
<title>Abstract</title> <bold>Background:</bold> Research exploring the link between immune cell profiles and development of endometritis remains scant. This gap necessitates further study to decode complex interrelations influencing this condition. <bold>Methods:</bold> In analysis, we leveraged two-sample Mendelian randomization examine causal ties phenotypes cells incidence endometritis. Our evaluation hinged on data from 3,757 participants hailing Sardinia, focusing a diverse array 731...
Abstract Blocking the PD-(L)1 immune checkpoint axis with therapeutic antibodies against either receptor or ligand has proven to be an effective treatment modality for multiple cancer histologies. We describe identification and characterization of novel small molecule antagonists that function by inducing dimerization subsequent internalization PD-L1 protein, effectively depleting from cell membrane preventing PD-1 activation on T cells. Compound-dependent was characterized using several...
Supplementary Figure from Characterization of INCB086550: A Potent and Novel Small-Molecule PD-L1 Inhibitor
Abstract C 18 H N 2 O 5 , monoclinic, P 1 / n a = 8.605(5) Å, b 8.496(4) c 23.771(5) β 95.853(19)°, V 1728.7(12) Å 3 Z 4, R gt ( F ) 0.0461, wR ref 0.1309, T 296 K.
Abstract Monoclonal antibodies against PD-L1 or PD-1 have been approved for the treatment of multiple tumor histologies by virtue their ability to restore T cell effector function, increase proliferation and enhance infiltration tumor-reactive cells. A small molecule approach PD-(L)1 axis blockade may offer distinct benefits over use monoclonal including improved tissue penetration, titratability, absence immunogenicity, ease administration, potential fixed dose oral-oral therapeutic...
Abstract C 16 H 13 ClN 2 O , monoclinic, 2/ c (no. 15), a = 13.7576(10) Å, b 11.0534(5) 19.6232(14) β 107.776(8)°, V 2841.6(3) Å 3 Z 8, R gt ( F ) 0.0407, wR ref 0.1105, T 293(2) K.