A5036134055- Monoclonal and Polyclonal Antibodies Research
- Cell Adhesion Molecules Research
- Glycosylation and Glycoproteins Research
- Advanced biosensing and bioanalysis techniques
- Immunotherapy and Immune Responses
- Aquaculture disease management and microbiota
- Cellular Mechanics and Interactions
- Antibiotic Resistance in Bacteria
- Iron Metabolism and Disorders
- Erythropoietin and Anemia Treatment
- Escherichia coli research studies
- Antimicrobial Peptides and Activities
- Biosimilars and Bioanalytical Methods
- Insect Resistance and Genetics
- Environmental Toxicology and Ecotoxicology
- Bacteriophages and microbial interactions
- Biosensors and Analytical Detection
- Biochemical and Structural Characterization
- Toxin Mechanisms and Immunotoxins
- Vibrio bacteria research studies
- Insect and Pesticide Research
Institut Pasteur de Tunis
2018-2025
Tunis El Manar University
2020-2025
Tunis University
2022
The extracellular matrix (ECM) molecule Tenascin-C (TNC) is well-known to promote tumor progression by multiple mechanisms. However, reliable TNC detection in tissues of banks remains limited. Therefore, we generated dromedary single-domain nanobodies Nb3 and Nb4 highly specific for human (hTNC) characterized the interaction with several approaches including ELISA, western blot, isothermal fluorescence titration negative electron microscopic imaging. Our results revealed binding both...
Scorpion envenoming is a severe health problem in many regions causing significant clinical toxic effects and fatalities. In the Middle East/North Africa (MENA) region, Buthidae scorpion stings are responsible for devastating outcomes human. The only available specific immunotherapeutic treatment based on IgG fragments of animal origin. To overcome limitations classical immunotherapy, we have demonstrated vivo efficacy NbF12-10 bispecific nanobody at preclinical level. Nanobodies were...
New Delhi Metallo-β-lactamase-1 (NDM-1) is the most prevalent type of metallo-β-lactamase, able to hydrolyze almost all antibiotics β-lactam group, leading multidrug-resistant bacteria. To date, there are no clinically relevant inhibitors fight NDM-1. The use dromedary polyclonal antibody against NDM-1 represents a promising new class molecules with inhibitory activity. In current study, immunoreactivities Immunoglobulin G (IgG) isotypes containing heavy-chain and conventional antibodies...
The injudicious usage of antibiotics during infections caused by Gram-negative bacteria leads to the emergence β-lactamases. Among them, NDM-1 enzyme poses a serious threat human health. Developing new or inhibiting β-lactamases might become essential reduce and prevent bacterial infections. Nanobodies (Nbs), smallest antigen-binding single-domain fragments derived from Camelidae heavy-chain-only antibodies, targeting enzymes, are innovative alternatives develop effective inhibitors....
Integrated pest management based on the use of biopesticides is largely applied. Experimental bioassays are critical to assess biopesticide biosafety at ecotoxicological level. In this study, we investigated effects new
The potency of a recombinant human erythropoietin (rhEPO) pharmaceutical preparation was evaluated by the normocythaemic mice bioassay using standardized and randomized protocol European Pharmacopeia 5.0. Eight-week-old B6D2F1/c received single daily injections test solutions (EPOTIN erythropoietin, batch preparation) at different concentrations. Erythropoietin biological reference product (batch 3.3) used as standard. suitability recorded according to gender age. blood sampling performed 4...