A5017054737- Cardiac Arrest and Resuscitation
- Cytokine Signaling Pathways and Interactions
- Bone health and osteoporosis research
- Hip and Femur Fractures
- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- Rheumatoid Arthritis Research and Therapies
- Osteoarthritis Treatment and Mechanisms
- Sarcoma Diagnosis and Treatment
- Gout, Hyperuricemia, Uric Acid
- Adipokines, Inflammation, and Metabolic Diseases
- Nosocomial Infections in ICU
- Protease and Inhibitor Mechanisms
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Bone health and treatments
- Bone Tumor Diagnosis and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Abdominal vascular conditions and treatments
- Respiratory Support and Mechanisms
- Medicinal Plants and Neuroprotection
- Spine and Intervertebral Disc Pathology
- Bone and Joint Diseases
- Spinal Fractures and Fixation Techniques
- Musculoskeletal synovial abnormalities and treatments
- Advanced Nanomaterials in Catalysis
Chung Shan Medical University
2014-2025
Chung Shan Medical University Hospital
2014-2024
Osteoarthritis (OA) and rheumatoid arthritis (RA) are two of the most common types arthritis. Both characterized by infiltration a number proinflammatory cytokines into joint microenvironment. miRNAs play critical roles in disease processes arthritic disorders. However, little is known about effects on inflammatory cytokine production with OA RA progression. Here, we found higher levels including interleukin 1 beta (IL-1β), 6 (IL-6) tumor necrosis factor alpha (TNF-α) human synovial...
Osteoporosis is a chronic inflammatory condition that characterized by the loss of bone mineral density (BMD). The current study was undertaken to evaluate impact onion juice intake on (BMD) and in corroboration with antioxidant effects human (in vivo) as well inhibitory differentiation osteoclasts cell line vitro). For vitro studies, RAW 264.7 (osteoclast progenitor) cells were used examine anti-osteoclastogenic effect onion. In case vivo twenty-four subjects divided into two groups advised...
Angiogenesis is a critical process in the formation of new capillaries and key participant rheumatoid arthritis (RA) pathogenesis. Vascular endothelial growth factor (VEGF) stimulation progenitor cells (EPCs) facilitates angiogenesis progression RA. Phosphorylation sphingosine kinase 1 (SphK1) produces sphingosine-1-phosphate (S1P), which increases inflammatory cytokine production, although role S1P RA unclear. In this study, we evaluated impact treatment on VEGF-dependent osteoblast-like...
Osteoarthritis (OA) is a long‑term, degenerative joint disease that presents significant clinical challenges and imposes considerable financial burdens. Fibrosis closely intertwined with the pathogenesis of various diseases, including OA. Using data from GDS5401 dataset, present study determined expression levels fibrosis factor connective tissue growth (CTGF) were significantly higher in OA patients than normal individuals. The also identified CTGF elevated both compared healthy controls...
Osteosarcoma is a malignant bone tumor affecting adolescents and children. No effective treatment currently available. Asiatic acid (AA), triterpenoid compound found in Centella asiatica, possesses anti-tumor, anti-inflammatory, anti-oxidant properties various types of cells. This study aims to determine whether AA exerts antitumor effects human osteosarcoma Our results indicate that does not influence the viability, proliferative rate, or cell cycle phase cells under non-toxic conditions....
Chondrosarcoma is the second most common type of bone cancer. At present, effective clinical course action surgical resection. Cisplatin chemotherapeutic medication widely used for treatment chondrosarcoma; however, its effectiveness severely hampered by drug resistance. In current study, we compared cisplatin-resistant chondrosarcoma SW1353 cells with their parental via RNA sequencing. Our analysis revealed that glutamine metabolism highly activated in resistant but glucose not....
Pathophysiological events that modulate the progression of structural changes in osteoarthritis (OA) include monocyte adhesion and infiltration, synovial inflammation. In particular, protein intercellular molecule type 1 (ICAM-1) promotes recruitment into tissue. Visfatin is an adipocyte hormone release inflammatory cytokines during OA progression. We report visfatin enhances ICAM-1 expression human fibroblasts (OASFs) facilitates monocytes with OASFs. AMPK p38 inhibitors, as well their...
Rheumatoid arthritis (RA) is an erosive polyarthritis that can lead to severe joint destruction and painful disability if left untreated. Angiogenesis, a critical pathogenic mechanism in RA, attracts inflammatory leukocytes into the synovium, which promotes production of proinflammatory cytokines destructive proteases. Adipokines, mediators secreted by adipose tissue, also contribute pathophysiology RA. The most abundant serum adipokine adiponectin, demonstrates effects although mechanisms...
Abstract Chondrosarcoma is a malignant bone tumor that emerges from abnormalities in cartilaginous tissue and related with lung metastases. Nicotinamide phosphoribosyltransferase (NAMPT) an adipocytokine reported to enhance metastasis. Our results clinical samples the Gene Expression Omnibus data set reveal NAMPT levels are markedly higher chondrosarcoma patients than normal individuals. stimulation significantly increased lysyl oxidase (LOX) production cells. Additionally, LOX‐dependent...
The risk of invasive Candida infection (ICI) is high in patients with perforated peptic ulcer (PPU) who received laparotomy or laparoscopic surgery, but the factors and predictors morbidity outcomes remain uncertain. This study aims to identify ICI surgical critically ill PPU evaluate impact on patient's outcomes. a single-center, retrospective study, total 170 patients. Thirty-seven were present 133 absent subjects. differences pulmonary complications according candidiasis determined by...
In patients experiencing out-of-hospital cardiac arrest (OHCA), hypotension is common after return of spontaneous circulation (ROSC). Both dopamine and norepinephrine are recommended as inotropic therapeutic agents. This study aimed to determine the impact use these two medications on hypotension. a multicenter retrospective cohort study. OHCA with ROSC were divided into three groups according post resuscitation agent used for treatment in emergency department, namely, dopamine,...
Background Chronic pain and limited activities of daily living after spinal fracture may induce the occurrence major depression (MD); however, risk factors regarding medications, surgical intervention, severity are unclear. We aimed to analyze MD development fracture. Methods This was a retrospective database study, using health care Taiwan government. included 11,225 patients with new (study group), 33,675 matched without (comparison group). respectively reviewed data each participant for 3...