A5036258446- HIV Research and Treatment
- Animal Disease Management and Epidemiology
- Virus-based gene therapy research
- Zoonotic diseases and public health
- Herpesvirus Infections and Treatments
- Chromosomal and Genetic Variations
- CRISPR and Genetic Engineering
- Animal Virus Infections Studies
- Viral Infections and Vectors
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- T-cell and Retrovirus Studies
- Hepatitis B Virus Studies
- Tumors and Oncological Cases
- Genomics and Phylogenetic Studies
- Health and Medical Research Impacts
- Amphibian and Reptile Biology
- Microbial infections and disease research
- Viral gastroenteritis research and epidemiology
- Animal Behavior and Reproduction
- Histiocytic Disorders and Treatments
- Helminth infection and control
- Veterinary Practice and Education Studies
- Bird parasitology and diseases
- Travel-related health issues
City University of Hong Kong
2024-2025
Colorado State University
2015-2024
University of California, Davis
2023-2024
Veterinary Medical Teaching Hospital
2023
Collins College
2021
Florida Fish and Wildlife Conservation Commission
2018
Exogenous feline leukemia virus (FeLV) is a gammaretrovirus that results in variety of disease outcomes. Endogenous FeLV (enFeLV) replication-defective provirus found species belonging to the Felis genus, which includes domestic cat (Felis catus). There have been few studies examining interaction between enFeLV genotype and progression. We examined point-in-time viral loads, as well occurrence FeLV/enFeLV recombinants (FeLV-B), determine factors relating clinical closed breeding colony cats...
Abstract The endangered Florida panther (Puma concolor coryi) had an outbreak of infection with feline leukemia virus (FeLV) in the early 2000s that resulted deaths 3 animals. A vaccination campaign was instituted during 2003–2007 and no additional cases were recorded until 2010. During 2010–2016, six FeLV documented. We characterized genomes isolated from panthers both outbreaks compared them full-length FeLVs contemporary domestic cats. Phylogenetic analyses identified at least 2...
Abstract The outbreak and transmission of disease-causing pathogens are contributing to the unprecedented rate biodiversity decline. Recent advances in genomics have coalesced into powerful tools monitor, detect, reconstruct role impacting wildlife populations. Wildlife researchers thus uniquely positioned merge ecological evolutionary studies with genomic technologies exploit “Big Data” disease research; however, many lack training expertise required use these computationally intensive...
Sarcocystis pinnipedi is an apicomplexan protozoal parasite that was first recognized during a mass mortality event in juvenile grey seals ( Halichoerus grypus) the northwest Atlantic Ocean. Since its identification, this has been reported various pinniped species and associated with fatal necrotizing hepatitis. Little known of host range S. pinnipedi. Here we report 2 cases California sea lions Zalophus californianus) managed care died following 8-d history inappetence, vomiting, diarrhea,...
Feline leukemia virus (FeLV) is a felid retrovirus with variety of disease outcomes. Exogenous FeLV-A the subgroup almost exclusively transmitted between cats.
Feline leukemia virus (FeLV) is a gammaretrovirus with horizontally transmitted and endogenous forms. Domestic cats are the primary reservoir species, but FeLV outbreaks in endangered Florida panthers Iberian lynxes have resulted mortalities. To assess prevalence interspecific/intraspecific transmission, we conducted an extensive survey phylogenetic analysis of infection free-ranging pumas (n = 641) bobcats 212) shelter domestic 304). Samples were collected from coincident habitats across...
Feline leukemia virus (FeLV) can infect a variety of felid species. Only the primary domestic cat host and related small species harbor endogenous in their genomes. Previous studies noted negative association between copy number exogenous infection cats. This report shows that puma cells, which lack FeLV, produce more rapidly than fibroblasts following cell culture challenge. We document strong susceptibility FeLV long terminal repeat (LTR) number, similar to observations natural infections....
Abstract Feline leukemia virus (FeLV) is associated with a range of clinical signs in felid species. The primary hosts FeLV are domestic cats the Felis genus that also harbor endogenous (enFeLV) elements stably integrated their genomes. EnFeLV display 86% nucleotide identity to exogenous, horizontally transmitted (FeLV-A). Variation between enFeLV and FeLV-A primarily long terminal repeat (LTR) env regions, which potentiates generation FeLV-B recombinant subtypes during natural infection...
Endogenous retroviruses (ERVs) are increasingly implicated in host cellular processes and susceptibility to infectious agents, specifically regarding interactions with exogenous retroviral progenitors (XRVs). Exogenous feline leukemia virus (FeLV) its endogenous counterpart (enFeLV) represent a well-characterized, naturally occurring XRV-ERV dyad.
Identifying drivers of transmission-especially emerging pathogens-is a formidable challenge for proactive disease management efforts. While close social interactions can be associated with microbial sharing between individuals, and thereby imply dynamics important transmission, such associations obscured by the influences factors as shared diets or environments. Directly-transmitted viral agents, specifically those that are rapidly evolving many RNA viruses, allow high-resolution inference...
Objectives Several studies have reported that domestic cats can be naturally infected with bovine herpesvirus 4 (BHV4). Cats experimentally inoculated BHV4 developed clinical signs involving the urinary tract, leading to hypothesis natural infection may associated feline lower tract diseases. However, question of whether is common in remains equivocal. In this study, we sought determine a USA. Methods We used sensitive nested PCR protocol specific thymidine kinase gene screen free-ranging...
Abstract Endogenous retroviruses (ERV) are indicators of vertebrate evolutionary history and play important roles as homeostatic regulators. ERV long terminal repeat (LTR) elements may act cis-activating promoters or trans-activating enhancer modifying gene transcription distant from LTR insertion sites. We previously documented that endogenous feline leukemia virus (FeLV)-LTR copy number variation in individual cats tracks inversely with susceptibility to virulent FeLV disease. To evaluate...
Abstract A climbing mantella frog ( Mantella laevigata ) was presented with nodular thickened skin. Histological examination revealed dermal nodules composed of differentiated bone consistent miliary osteoma cutis, a non‐neoplastic condition where is abnormally deposited within the This first report idiopathic cutis in an amphibian.
Abstract Feline pulmonary Langerhans cell histiocytosis (FPLCH) is a rare histiocytic proliferative disease of middle‐aged to older domestic cats. cells in the terminal airways proliferate and infiltrate interstitium lesser degree, widely effacing normal parenchyma. Historically, definitive diagnosis has required postmortem evaluation where lesions have classic gross histologic morphology. Here, we present first documented antemortem FPLCH using bronchoalveolar lavage (BAL) cytology...
Abstract Identifying drivers of transmission prior to an epidemic—especially emerging pathogen—is a formidable challenge for proactive disease management efforts. We tested novel approach in the Florida panther, hypothesizing that apathogenic feline immunodeficiency virus (FIV) could predict dynamics pathogenic leukemia (FeLV). derived network using FIV whole genome sequences, and used exponential random graph models determine structuring this network. these FeLV pathways among panthers...
Issues in the fields of wildlife disease and One Health are often difficult to address by single research groups because many disciplines areas expertise required effectively solve complex problems. Although collaborations becoming increasingly prevalent professional realm, undergraduate, graduate, students merely introduced idea collaboration without fully understanding how team-based approaches function. In this report, we describe framework for a one-day workshop hosted Colorado State...
Abstract While feline leukemia virus (FeLV) has been shown to infect felid species other than the endemic domestic cat host, differences in FeLV susceptibility among not evaluated. Previous reports have noted a negative correlation between enFeLV copy number and exogenous infection outcomes cats. Since felids outside genus Felis do harbor genomes, we hypothesized absence of results more severe disease consequences lacking these genomic elements. We infected primary fibroblasts isolated from...
Abstract Endogenous retroviruses (ERVs) are increasingly recognized for biological impacts on host cell function and susceptibility to infectious agents, particularly in relation interactions with exogenous retroviral progenitors (XRVs). ERVs can simultaneously promote restrict XRV infections using different mechanisms that virus- host-specific. The majority of endogenous-exogenous have been evaluated experimental mouse or chicken systems which limited their ability extend findings naturally...