A5036319970- Metabolism, Diabetes, and Cancer
- Peroxisome Proliferator-Activated Receptors
- Cancer, Lipids, and Metabolism
- Toxin Mechanisms and Immunotoxins
- Cancer, Stress, Anesthesia, and Immune Response
- Genetic diversity and population structure
- Vector-borne infectious diseases
- Bird parasitology and diseases
- Genomics and Phylogenetic Studies
- Histone Deacetylase Inhibitors Research
- Viral Infections and Vectors
- Inhalation and Respiratory Drug Delivery
- Synthesis and biological activity
- Genetic and phenotypic traits in livestock
- Plant and Fungal Interactions Research
- Ichthyology and Marine Biology
- Livestock and Poultry Management
- Retinoids in leukemia and cellular processes
- Antioxidant Activity and Oxidative Stress
- PI3K/AKT/mTOR signaling in cancer
- Animal Disease Management and Epidemiology
- Insect symbiosis and bacterial influences
- Carbohydrate Chemistry and Synthesis
- Forest Insect Ecology and Management
- Marine and coastal plant biology
Purdue University West Lafayette
2015-2021
University of Minnesota
2010-2019
State Street (United States)
2019
Abstract The outbreak and transmission of disease-causing pathogens are contributing to the unprecedented rate biodiversity decline. Recent advances in genomics have coalesced into powerful tools monitor, detect, reconstruct role impacting wildlife populations. Wildlife researchers thus uniquely positioned merge ecological evolutionary studies with genomic technologies exploit “Big Data” disease research; however, many lack training expertise required use these computationally intensive...
Abstract Combination treatment with pioglitazone and metformin is utilized clinically in the of type II diabetes. Treatment this drug combination reduced development aerodigestive cancers patient population. Our goal to expand into clinical lung cancer chemoprevention. We hypothesized that dietary delivery metformin/pioglitazone would prevent adenoma formation A/J mice a benzo[a]pyrene (B[a]P)-induced carcinogenesis model while modulating chemoprevention anti-inflammatory biomarkers residual...
Genetic and genomic approaches have much to offer in terms of ecology, evolution, conservation. To better understand the biology gray whale Eschrichtius robustus (Lilljeborg, 1861), we sequenced genome produced an assembly that contains ∼95% genes known be highly conserved among eukaryotes. From this assembly, annotated 22,711 identified 2,057,254 single-nucleotide polymorphisms (SNPs). Using generated a curated list candidate potentially subject strong natural selection, including...
In the arms race between hosts and parasites, genes involved in immune response are targets for natural selection. Toll-Like Receptor (TLR) play a role parasite detection as part of innate system whereas Major Histocompatibility Complex (MHC) encode proteins that display antigens vertebrate adaptive system. Thus, both gene families under selection pressure from pathogens. The bananaquit (Coereba flaveola) is passerine bird common host avian malarial parasites (Plasmodium sp. Haemoproteus...
Abstract Pioglitazone is a PPARγ agonist commonly prescribed for the clinical treatment of diabetes. We sought to expand its use lung cancer prevention in benzo[a]pyrene (B[a]P) mouse model with direct delivery via inhalation. Initially, we conducted inhalational toxicity experiments 0, 15, 50, 150, and 450 μg/kg body weight/day pioglitazone 40 A/J mice. examined animals any physical bronchoalveolar lavage fluids inflammatory cytotoxicity markers. Doses up including bw/d failed demonstrate...
Abstract Nicotinamide, the amide form of vitamin B3, and budesonide, a synthetic glucocorticoid used in treatment asthma, were evaluated to determine their individual combinational chemopreventive efficacy on benzo(a)pyrene-induced lung tumors female A/J mice. Nicotinamide fed at dietary concentration 0.75% significantly inhibited tumor multiplicity. by aerosol inhalation doses up 15 mg/kg/day did not result statistically significant reduction Finally, nicotinamide was administered with...
Genetic diversity (GD) is largely determined by effective population size, which may vary dramatically for species that differ in key aspects of their biology such as vagility. To identify evolutionary patterns associated with animal distributions and movements, we examined relationships among GD (i.e. microsatellite heterozygosity allelic richness), taxonomic class, biome migratory behaviour. Linear regression revealed mammals, reptiles, amphibians fishes had less compared to nonmigratory...
Abstract A consistent observation in studies of carcinogenesis is that some glycans are expressed differently cancer cells than normal cells. well-known example the aberrant β1–6 N-acetyl-d-glucosamine branching associated with metastasis and poor prognosis many cancers. This commentary proposes that, although not found mammalian cells, a chitin (β-1,4-linked N-acetyl-d-glucosamine) or chitin-like polysaccharide (e.g., hyaluronan) may exist as cancer-associated glycan, which can be targeted...
ABSTRACT American elm, Ulmus americana L., was cultivated widely in USA and Canada as a landscape tree, but the genome of this important species is poorly characterized. For first time, we describe sequencing assembly chloroplast genomes two elm genotypes (RV16 Am57845). The complete U. ranged from 158,935-158,993 bp. contains 127 genes, including 85 protein-coding 34 tRNA genes 8 rRNA genes. Between chloroplasts sequenced, identified 240 sequence variants (SNPs indels). To evaluate...
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<div>Abstract<p>Combination treatment with pioglitazone and metformin is utilized clinically in the of type II diabetes. Treatment this drug combination reduced development aerodigestive cancers patient population. Our goal to expand into clinical lung cancer chemoprevention. We hypothesized that dietary delivery metformin/pioglitazone would prevent adenoma formation A/J mice a benzo[<i>a</i>]pyrene (B[<i>a</i>]P)-induced carcinogenesis model while...
<div>Abstract<p>Combination treatment with pioglitazone and metformin is utilized clinically in the of type II diabetes. Treatment this drug combination reduced development aerodigestive cancers patient population. Our goal to expand into clinical lung cancer chemoprevention. We hypothesized that dietary delivery metformin/pioglitazone would prevent adenoma formation A/J mice a benzo[<i>a</i>]pyrene (B[<i>a</i>]P)-induced carcinogenesis model while...
<div>Abstract<p>Nicotinamide, the amide form of vitamin B3, and budesonide, a synthetic glucocorticoid used in treatment asthma, were evaluated to determine their individual combinational chemopreventive efficacy on benzo(<i>a</i>)pyrene-induced lung tumors female A/J mice. Nicotinamide fed at dietary concentration 0.75% significantly inhibited tumor multiplicity. by aerosol inhalation doses up 15 mg/kg/day did not result statistically significant reduction Finally,...
<p>Supplemental Figure 2</p>
<p>Supplemental Figure 1</p>
<p>Supplemental Figure 1</p>
<p>Supplemental Figure Legends</p>
<p>Supplemental Figure 2</p>
<p>Supplemental Figure Legends</p>
<div>Abstract<p>Nicotinamide, the amide form of vitamin B3, and budesonide, a synthetic glucocorticoid used in treatment asthma, were evaluated to determine their individual combinational chemopreventive efficacy on benzo(<i>a</i>)pyrene-induced lung tumors female A/J mice. Nicotinamide fed at dietary concentration 0.75% significantly inhibited tumor multiplicity. by aerosol inhalation doses up 15 mg/kg/day did not result statistically significant reduction Finally,...