The serum levels of interferon (IFN) in 58 patients with Behçet's disease were significantly higher than those 79 normal controls (P less 0.0001). average IFN titer was 51.4 +/- 9.3 IU/ml the and 5.9 1.1 controls. then divided into two groups according to stage ocular disease. Forty-six convalescent had (61.3 11.2 IU/ml) did 12 exacerbation (13.2 3.0 IU/ml). Moreover, kinetics level circulation seven showed a significant decrease stage. activity sera from destroyed by acid treatment heating...

The bioavailability of orally administrated cyclosporine A (CsA) is poor and variable in liver transplantation recipients. Little information available about the effect ischemia-reperfusion (I/R) injury, which associated with transplantation, on intestinal first-pass metabolism CsA. In present study, we investigated pharmacokinetics CsA after I/R assessed via CYP3A P-glycoprotein (P-gp) its metabolism. When alone was orally, area under concentration-time curve (AUC) rats significantly...

Adenosine modulates a wide variety of biological processes via adenosine receptors. In the exocrine pancreas, regulates transepithelial anion secretion in duct cells and is considered to play role acini-to-duct signaling. To identify functional receptors Cl− channels important for secretion, we herein performed experiments on Capan-1, human pancreatic cell line, using open-circuit Ussing chamber gramicidin-perforated patch-clamp techniques. The luminal addition increased negative potential...

1. The block of the inwardly rectifying K+ channel by intracellular Ca2+ was studied in guinea-pig ventricular cells. 2. Single-channel currents through were recorded inside-out configuration at 150 mM external and internal K+. Internal Ca2+, a concentration 0.4-10 microM, induced subconductance levels with one-third two-thirds unitary amplitude outward without affecting inward currents. 3. Occupancy each sublevel estimated from histogram which showed four equally spaced peaks presence Ca2+....

Currents through the inwardly, rectifying K channel were studied under whole-cell clamp of collagenase-treated single ventricular cells guinea-pigs. The inwardly was fully activated by hyperpolarizing membrane from equilibrium potential for K+ (EK) 30-40mV. Following depolarization above EK, a decaying outward current elicited. Prolongation prepulse increased amplitude current, with time course similar to increase inward during prepulse. Time-dependent changes in both and currents could be...

Abstract The carbonyl stretching vibrations of the title compounds were studied using DFT calculations at B3LYP/6-311G** level and IR spectra in terms intramolecular hydrogen bond (H-bond). Two types H-bond systems examined: type I which H-atom OH group points towards to neighboring oxygen atom, II away. results show that 2-hydroxy-1,4-naphthoquinone (1), 3-chloro-2-hydroxy-1,4-naphthoquinone (2), 3-bromo-2-hydroxy-1,4-naphthoquinone (3), 2-hydroxy-3-iodo-1,4-naphthoquinone (4) CCl4, are...

The electrophysiological effects of 0.2 mg/kg intravenously administered verapamil (mean plasma level, 51.3 ng/ml) were evaluated using intracardiac recordings and electrical stimulation in 10 patients with the concealed or manifest Wolff-Parkinson-White syndrome. Verapamil produced a minimal effect on both antegrade retrograde effective refractory periods accessory pathway conduction time over pathway, but significantly lengthened intranodal as well functional atrioventricular (AV) node....

In recent years, dried nori with a high protein content has been commercialized as tasty produce. Although free amino acids have examined taste components of nori, the constituting and their roles not identified. Therefore, we carried out sensory evaluations to identify taste-active determine in taste. The main extractive were Ala, Glu, Asp. addition these components, Tau was also abundant. These four accounted for 85% acids. ATP-related compound IMP. Together, five compounds identified...

The intracellular potassium content of perfused rat heart was measured by potassium-39 nuclear magnetic resonance (NMR) spectroscopy at 33 degrees C with an inversion recovery technique based on the fact that spin-lattice relaxation time (T1) (8.3 msec 8.45 T) is much faster than extracellular (68 msec). Intracellular decreased to 60.2 +/- 4.3% control level (mean SEM, n = 6) 40 minutes from start metabolic inhibition (2 mM cyanide, 0 glucose). Removal cyanide restored 94.2 3.9% 30 restart...

To evaluate the influence of proteinuria on renal Doppler sonographic (US) measurements in patients with chronic kidney disease (CKD) or without diabetes mellitus (DM).Renal resistance index (RI), pulsatility (PI), and maximum length were measured by US 113 suffering from CKD DM (non-DM patients) 120 diabetic nephropathy (DM patients). Other data collected sex, age, body mass index, blood pressure, estimated glomerular filtration rate, urinary protein level, medical history. The effect RI PI...

Green-plant membrane is a phytonutrient present in green leafy vegetables at high concentration. Postprandial increases blood triglyceride levels result insulin resistance and type 2 diabetes. Additionally, dietary life eating order also affect postprandial hypertriglyceridemia. In this study, the effects of once-daily intake green-plant with oil on hypertriglyceridemia were investigated vitro vivo. vitro, bound hydrophobic bile acids but did not inhibit pancreatic lipase activity. Following...

Pharmacological effects on anti-diuresis, anti-ulceration, anti-dementia and learning function of 50% ethanolic extract (AO-ext) from Alpiniae Fructus (fruit Alpinia oxyphylla) removed seedvessel were investigated in order to prove the evidence efficacy ancient herbal literature. AO-ext showed increase animals. And also, exhibited increasing effect serum 11-hydroxycorticosteroid (11-OHCS) level above-described experimental animals intact hypophysectomized rats.

The pancreatic duct epithelium secretes the HCO3--rich juice. HCO3- transport across luminal membrane has been proposed to be mediated by SLC26A Cl--HCO3- exchangers. To examine electrophysiological properties of exchangers, we directly measured conductance in interlobular cells from guinea pigs using an inside-out patch-clamp technique. Intracellular increased with a half-maximal effective concentration value approximately 30 mM. selectivity sequence based on permeability ratios was SCN-...

Abstract Background Phenobarbital (PB) is commonly used as elixir and powder formulations in pediatric care. Its dose adjustment performed based on individual drug concentration monitoring. Few studies have comprehensively analyzed the variation factors for serum PB concentration. In this study, we retrospectively investigated that influence assessed impacts of dosage formulation administration route. Methods This retrospective cohort study covered clinical data from January 2007 to...

The electrophsiological effects of nicardipine-HCl, a new calcium antagonist and potent vasodilator, were studied in the isolated sinoatrial (SA) atrioventricular (AV) nodes rabbit an oxygenated Tyrode solution at 35°C using intracellular microelectrode technique. Nicardipine-HCl decreased spontaneous rate SA node prolonged sinus recovery time, dose-dependently. effective refractory period (ERP) functional (FRP) AV conduction time (A-H interval) also by nicardipine-HCl dose-dependent manner....

D-Aspartate, aspartate racemase activity, and D-aspartate oxidase activity were detected in tissues from several types of starfish. Aspartate male testes Patiria pectinifera was significantly elevated the summer months breeding season compared with spring months. We also gonad index found that individuals a ≥6% four-fold higher than <6%. The ratio D-form to total approximately 25% <6% this increased 40% ≥6%. However, such changes not observed female ovaries. Administration into starfish...

The ductal system of the exocrine pancreas produces HCO(3)(-)-rich fluid in response to secretin and other stimuli. HCO(3)(-) efflux across luminal membrane is mediated by a Cl(-)-HCO(3)(-) exchanger operating parallel with cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel. Basolateral K(+) channels provide an exit pathway for play vital role maintaining potential, which crucial component driving force anion secretion. Measurements potential intracellular...