Abstract Background At present, individualized interventions can be given to patients with a clear etiology of pregnancy loss improve the subsequent outcomes, but current reproductive status patient cannot changed. The aim this study was investigate association between female and subsequence outcome in prior (PL). Methods A prospective, dynamic population cohort carried out at Second Hospital Lanzhou University. From September 2019 February 2022, total 1955 women least one previous PL were...

The aim of this study is to construct a nomogram for predicting subsequent early pregnancy loss in women with history loss, which may increase well-being and the capacity managing reproductive options. We conducted retrospective analysis medical records from at Reproductive Medicine Center Lanzhou University Second Hospital between January 2019 December 2022. A cohort 718 patients was selected study. structured our data into training set 575 cases (80% cohort) test 143 (20%). To identify...

Abstract Problem Studies on subsequent pregnancy loss prediction models specific for recurrent (RPL) patients are very limited. This study aims to develop a risk predictive model based the immunological parameters in northwest Chinese RPL patients. Method of Totally 357 recruited from Lanzhou University Second Hospital were included this retrospective study. Univariate analysis was performed with outcomes live birth or loss. Subsequently, least absolute shrinkage and selection operator...

Establishing prediction models of pregnancy outcomes for recurrent loss women at specific gestational weeks will provide patients and physicians with more precise information, ultimately leading to time cost savings associated unnecessary revisits. Therefore, our aim was develop a model first trimester in RPL patients. We used ultrasound indices during the combination demographic characteristics commonly serum markers. The independent risk factors each week were as follows: age P fifth week;...

Abstract The aim of this study was to investigate the subsequent early pregnancy outcomes in women positive for non-criteria antiphospholipid antibodies (NC-aPLs) before pregnancy. A total 273 patients who had experienced sporadic or recurrent loss and been screened 13 NC-aPLs at preconception were recruited from September 2019 February 2022. Serum levels measured by ELISA using specific kits. primary outcome loss, secondary biochemical pregnancy, clinically confirmed ongoing Among these...

Self-management is crucial in managing recurrent pregnancy loss (RPL). This study explored the knowledge, attitudes, and practices (KAP) of patients with RPL toward RPL. cross-sectional was conducted among between January 2023 June at Second Hospital Lanzhou University. Participants' demographic characteristics KAP were determined using a self-designed questionnaire (Cronbach's α = 0.818). Structural equation modeling (SEM) used to observe correlations different factors. analyzed 497 valid...

Although tumor necrosis factor-alpha inhibitor (TNFi) treatment may improve pregnancy outcomes in unexplained recurrent miscarriage (URM) patients, evidence for its efficacy and safety is still insufficient. The goal of this study was to evaluate the TNFi on patients with URM. This retrospective conducted at a single institution China, involving 121 treated URM from 2019 2022. Patients enrolled were divided into group (receiving heparin therapy) control therapy). outcome variables 24-week...

This real-world study aimed to assess the clinical efficacy and safety of intravenous immunoglobulin (IVIG) in treating unexplained recurrent pregnancy loss (uRPL) patients. A total 238 patients with uRPL were enrolled this retrospective study. According treatment, assigned into treatment group (n=184, receiving IVIG+low molecular weight heparin [LMWH]) control (n=54, only LMWH). The primary outcome was live birth rates (LBR) after 24 weeks gestation. In addition, we performed subgroup...

Abstract Background Insulin resistance (IR), hyperuricemia (HUA), and recurrent pregnancy loss (RPL) elevate the risk of cardiovascular disease metabolic disorders, while also impacting reproductive health. The relationship between IR, HUA, RPL has not been thoroughly investigated. This study investigates four IR surrogates HUA in patients. Methods Data from a real‐world on China were analyzed using multivariable regression to determine triglyceride glucose (TyG) index, glucose‐body mass...

Abstract Background In assisted reproductive technology (ART), repeated implantation failure is bound to have a higher potential risk when compared first successful clinical pregnancy in ART. However, few studies comprehensively analyzed the influence of pre-ART cycle related factors on repeat failure. Therefore, our aim was identify influencing for RIF and explore different new cutoff values before Methods This retrospective cohort study 1581 patients successfully collected with ART Qinghai...

<title>Abstract</title> Background Granulocyte colony-stimulating factor (G-CSF) administration increased ovarian preantral follicles in animal models with diminished reserve. We retrospectively investigated whether G-CSF priming on superovulation initiation day assisted reproductive technology (ART) improved egg maturation and embryonic development patients poor Methods In this retrospective clinical case study, 174 aged 20 to 45 years were divided into a test group(40 each) control group...

Abstract Decreased estradiol (E2) levels are associated with early miscarriage (EM), but the relationship between decreased times of E2 and EM has not been reported. We aimed to investigate average (ADTE) EM. Women a history were retrospectively recruited from Reproductive Center Lanzhou University Second Hospital (Lanzhou, China) September 2019 February 2022. Based on pregnancy outcome, they divided into ongoing group ( n = 359) 104). In addition, subgroup analyses performed for number...

Abstract Problem To evaluate the correlation between antiannexin A5 antibodies (aAnxA5) multiples of median (MOM) and subsequent pregnancy outcomes in women with recurrent miscarriage (RM). Methods Totally, 310 RM were included this study grouped into tertiles according to their MOM preconception aAnxA5 circulating levels determined by ELISA. The effect on was performed using multiple logistic regression. early (before 10 weeks gestation), late (between 24 weeks), ongoing (beyond live birth...

Abstract Background Abnormal fetal tissue chromosome karyotypes are one of the important pathogenic factors for spontaneous abortion (SA). To analyze characteristics chromosomal karyotype in 778 women with a history SA and its relationship clinical features. Methods A retrospective study collected maternal age, body mass index (BMI), gestational weeks at miscarriage, number previous pregnancy losses CNV-seq data couples from Lanzhou University Second Hospital October 2019 to December 2023,...

Abstract Background For women who have experienced recurrent pregnancy loss (RPL), it is crucial not only to treat them but also evaluate the risk of recurrence. The study aimed develop a predictive model predict subsequent early (EPL) in with RPL based on preconception data. Methods A prospective, dynamic population cohort was carried out at Second Hospital Lanzhou University. From September 2019 December 2022, total 1050 non-pregnant were participated. By 2023, 605 had outcomes and...

Abstract This study aims to explore the link between dietary habits and adverse pregnancy outcomes (APOs), including preterm birth (PB), preeclampsia (PE), gestational diabetes mellitus (GDM), fetal growth restriction (FGR), spontaneous abortion (SA) through two‐sample Mendelian randomization (MR). We accessed publicly available genome‐wide association studies' (GWAS) summary statistics for APOs, respectively. used five MR methods synthesize estimates across genetic instruments. To ensure...

Approximately 17.5% of couples reproductive age have experienced infertility. Women with a poor ovarian response (POR) must undergo in vitro fertilisation (IVF) and embryo transfer to achieve pregnancy. However, studies reported gonadotropin stimulation women undergoing IVF-ET. Results from animal experiments suggest that granulocyte colony-stimulating factor (G-CSF) has curative effect by protecting function, reducing follicle loss delaying premature failure rats caused chemotherapy....