A5048899508- Silkworms and Sericulture Research
- Insect and Arachnid Ecology and Behavior
- Neurobiology and Insect Physiology Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Insect Resistance and Genetics
- Breast Cancer Treatment Studies
- CRISPR and Genetic Engineering
- Silk-based biomaterials and applications
- Breast Lesions and Carcinomas
- Viral Infectious Diseases and Gene Expression in Insects
- Insect symbiosis and bacterial influences
- Invertebrate Immune Response Mechanisms
- Insect Utilization and Effects
- Animal Genetics and Reproduction
- Animal Behavior and Reproduction
- Cardiac Health and Mental Health
- Chromosomal and Genetic Variations
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Plant Virus Research Studies
- Heart Rate Variability and Autonomic Control
- Renal cell carcinoma treatment
- Respiratory Support and Mechanisms
- Chronic Lymphocytic Leukemia Research
- Renal and related cancers
Shanghai Jiao Tong University
2024
Center for Excellence in Molecular Plant Sciences
2017-2023
University of Chinese Academy of Sciences
2020-2023
Chinese Academy of Sciences
2017-2023
University of Oxford
2017-2023
Shanghai Institutes for Biological Sciences
2017-2021
University of Kansas
2021
Northwestern Polytechnical University
2017-2018
University of Birmingham
2006-2017
University of Exeter
2011
Abstract Sperm, which have a vital role in sexual reproduction the animal kingdom, can display heteromorphism some species. The regulation of sperm dichotomy remains longstanding puzzle even though phenomenon has been widely documented for over century. Here we use Bombyx mori as model to study form dimorphism (eupyrene and apyrene sperm), is nearly universal among Lepidoptera. We demonstrate that B. Sex-lethal ( BmSxl ) crucial development, poly(A)-specific ribonuclease-like...
In lepidopteran insects, dichotomous spermatogenesis produces eupyrene spermatozoa, which are nucleated, and apyrene anucleated. Both sperm morphs essential for fertilization, as fertilize the egg, is necessary migration of sperm. Drosophila , Prmt5 acts a type II arginine methyltransferase that catalyzes symmetrical dimethylation residues in RNA helicase Vasa. critical regulation spermatogenesis, but Vasa not. To date, functional genetic studies model Bombyx mori has been limited. this...
MicroRNAs (miRNAs) are important regulators of nearly all aspects biological processes in eukaryotes. During the biogenesis miRNAs, RNase III enzyme Dicer double-strand precursor miRNAs into mature and promotes assembly RNA-induced silencing complexes (RISCs). has been reported to participate a wide range physiological processes, including development immunity, some insect species. However, roles lepidopterans remain poorly understood. In this study, we investigated function Bombyx mori...
ABSTRACT microRNAs (miRNA) are small non-coding RNAs that modulate the myriad biological activities by targeting genes, and many studies showed miRNAs played a pivotal role in insect development. Here, we find Bm-miRNA (miR-34) controls larval growth wing morphology BmE74 BmCPG4. Overexpression of miR-34 whole body caused smaller size, partially displays deformed wings venation defects adults. Ablation transgenic CRISPR/Cas9 technology resulted severe developmental delay during stage....
Sperm deliver the male complement of DNA to ovum, and thus play a key role in sexual reproduction. Accordingly, spermatogenesis has outstanding significance fields as disparate infertility treatments pest-control, making it broadly interesting important focus for molecular genetics research wide range species. Here we investigate model lepidopteran insect Bombyx mori (silkworm moth), with particular on gene PMFBP1 (polyamine modulated factor 1 binding protein 1). In humans mouse, is...
Sex determination pathways are astoundingly diverse in insects. For instance, the silk moth Bombyx mori uniquely use various components of piRNA pathway to produce Fem signal for specification female fate. In this study, we identified BmGTSF1 as a novel factor which participates B . sex determination. We found that BmGtsf1 has distinct expression pattern compared Drosophila and mouse. CRISPR/Cas9 induced mutation resulted partial reversal genotypically animals by shifting downstream targets...
Insect courtship and mating depend on integration of olfactory, visual, tactile cues. Compared to other insects, Bombyx mori, the domesticated silkworm, has relatively simple sexual behaviors as it cannot fly. Here by using CRISPR/Cas9 electrophysiological techniques we found that are regulated in male silk moths mutating genes sex determination cascade belonging two conserved pathways. Loss Bmdsx gene expression significantly reduced peripheral perception major pheromone component bombykol...