A5001182420- Adipose Tissue and Metabolism
- Phytochemicals and Antioxidant Activities
- Metabolomics and Mass Spectrometry Studies
- Antioxidant Activity and Oxidative Stress
- Genomics and Phylogenetic Studies
- Estrogen and related hormone effects
- Bone Tissue Engineering Materials
- Muscle Physiology and Disorders
- Nitric Oxide and Endothelin Effects
- Exercise and Physiological Responses
- Advanced Proteomics Techniques and Applications
- Plant biochemistry and biosynthesis
- Microbial Community Ecology and Physiology
- Natural Antidiabetic Agents Studies
- Cardiovascular and exercise physiology
- Titanium Alloys Microstructure and Properties
- Plant Pathogens and Fungal Diseases
- Histone Deacetylase Inhibitors Research
- Mycorrhizal Fungi and Plant Interactions
- Aluminum Alloy Microstructure Properties
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipokines, Inflammation, and Metabolic Diseases
- Sirtuins and Resveratrol in Medicine
- Botanical Research and Applications
- Fibromyalgia and Chronic Fatigue Syndrome Research
Center for Scientific Research and Higher Education at Ensenada
2016-2024
University of Aberdeen
2022
Ensenada Institute of Technology
2021
University of California, San Diego
2012-2019
Indiana University School of Medicine
2015-2017
Instituto Politécnico Nacional
2012-2016
Xochicalco University
2016
Tecnológico Nacional de México
2015
Impact
1998
Impact Technology Development (United States)
1998
There is evidence implicating oxidative stress (OS) as the cause of deleterious effects aging. In this study, we evaluated capacity flavanol (−)-epicatechin (Epi) to reduce aging-induced OS and restore mitochondrial biogenesis, well as, structural functional endpoints in aged mice. Senile (S; 26-month-old) C57BL/6 male mice were randomly assigned receive either water (vehicle) or 1mg/kg Epi via oral gavage (twice daily) for 15 days. Young (Y; 6-month-old) used controls. S brain, kidney,...
We wished to examine the effects of dark chocolate on sedentary individuals' exercise capacity and underlying mechanisms.
(-)-Epicatechin increases indicators associated with mitochondrial biogenesis in endothelial cells and myocardium. We investigated nitric oxide synthase involvement on (-)-epicatechin-induced human coronary artery cultured normal-glucose high-glucose media, as well to restore of cardiac mitochondria from the effects simulated diabetes. Here, we demonstrate role proteins, transcription factors sirtuin 1 under conditions. In diabetes function, function-associated biogenesis-associated were...
Neovascularization over dental implants is an imperative requisite to achieve successful osseointegration onto implanted materials. The aim of this study was investigate the effects on in vitro angiogenesis anodized 70 nm diameter TiO2 nanotubes (NTs) Ti6Al4V alloy synthesized and disinfected by means a novel, facile, antibacterial cost-effective method using super oxidized water (SOW). We also evaluated role surface roughness chemical composition materials angiogenesis.The commercially pure...
Breastmilk is essential for neonatal development, particularly in seeding the gut microbiota and modulating maturing immune system. This proof-of-concept study explores systemic nature of colostrum influence maternal obesity on co-occurrences bioactives. Using 16S-rRNA sequencing, untargeted metabolomics, cytokines quantification, we analyzed co-occurring elements mothers with normal weight (18.5 < BMI 25) or (BMI > 30). We identified 5 different co-occurrence networks, characterized...
Objective . To evaluate the effects of ezetimibe/simvastatin (EZE/SIMV) and rosuvastatin (ROSUV) on oxidative stress (OS) markers in patients with diabetic polyneuropathy (DPN). Methods We performed a randomized, double-blind, placebo-controlled phase III clinical trial adult Type 2 Diabetes Mellitus (T2DM) DPN, as evaluated by composite scores nerve conduction studies (NCS). Seventy-four subjects T2DM were allocated 1 : to placebo, EZE/SIMV 10/20 mg, or ROSUV 20 mg for 16 weeks. All...
Titanium (Ti) and its alloys are amongst the most commonly-used biomaterials in orthopedic dental applications. The Ti-aluminum-vanadium alloy (Ti6Al4V) is widely used as a biomaterial for these applications by virtue of favorable properties, such high tensile strength, good biocompatibility excellent corrosion resistance. TiO₂ nanotube (NTs) layers formed anodization on Ti6Al4V have been shown to improve osteoblast adhesion function when compared non-anodized material. In his study, NTs...
Agaves are plants native to North America that sustain life in arid and semiarid ecosystems. Previous studies revealed cultivated of Agave tequilana had lower microbial diversity functionality than wild species. Here, we tested if synthetic communities (syncoms), based on hubs or taxa with enriched functions, could increase diversity, plant health, productivity A. tequilana. We applied 10 syncoms the phyllospheres 6-month-old field monitored their development for 2 years. Amplicon sequencing...
(−)-Epicatechin ((−)-EPI), a naturally occurring flavanol, has emerged as likely candidate for cocoa-based product reported reductions in cardiometabolic risk.
Although various studies have investigated osmoadaptations of halophilic fungi to saline conditions, only few analyzed the fungal mechanisms occurring at saturated NaCl concentrations. Halophilic Aspergillus sydowii is a model organism for study molecular adaptations filamentous hyperosmolarity. For first time multi-omics approach (i.e., transcriptomics and metabolomics) was used compare A. concentration (5.13 M NaCl) optimal salinity (1 NaCl). Analysis revealed 1,842 genes differentially...
The consumption of moderate amounts cocoa products has been associated with reductions in the incidence cardiovascular diseases. In animal studies, flavanol (-)-epicatechin (Epi) yields cardioprotection. effects may be partly due to its capacity stimulate endothelial nitric oxide synthase (eNOS). sustained activation eNOS, as observed exercise, can serve a trigger muscle angiogenesis via vascular growth factor (VEGF)–related events. Experiments were pursued examine potential Epi myocardial...
High-throughput technologies and emerging informatics tools have significantly advanced knowledge of hydrocarbon metabolism by marine microbes. However, research into microbes inhabiting deep-sea sediments (>1,000 m) is limited compared to those found in shallow waters. In this study, a nontargeted nonclassical approach was used examine the diversity bacterial taxa metabolic profiles hydrocarbon-degrading conclusion, study metabolomics chemoinformatics demonstrate that from sediment...
Petroleum-derived substances, like industrial oils and grease, are ubiquitous in our daily lives. Comprised of petroleum hydrocarbons (PH), these substances can come into contact with skin, potentially causing molecular disruptions contributing to the development chronic disease. In this pilot study, we employed mass spectrometry-based untargeted metabolomics 16S rRNA gene sequencing analyses explore effects. Superficial skin samples were collected from subjects without dermal exposure PH at...
The eggplant is a fruit rich in natural products and produced worldwide. However, its cultivation generates large amount of scarcely used agricultural residues with poor chemical characterization. This study aimed to identify quantify the metabolome determine composition select phytochemicals overall antioxidant capacity various anatomical parts plant. plant's root, leaf, stem, were analyzed by quantitative mass spectrometry-based untargeted metabolomics chemoinformatics, quantified...
We reported that (−)-epicatechin can stimulate mitochondria biogenesis and improve metabolism.