A5045151641- Histone Deacetylase Inhibitors Research
- interferon and immune responses
- Chromatin Remodeling and Cancer
- Cancer-related gene regulation
- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Cancer Mechanisms and Therapy
- Synthesis of Tetrazole Derivatives
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Toxin Mechanisms and Immunotoxins
- Cellular Mechanics and Interactions
- Plant Virus Research Studies
- Insect symbiosis and bacterial influences
- Vector-borne infectious diseases
- Heat shock proteins research
- Signaling Pathways in Disease
- Protein Kinase Regulation and GTPase Signaling
- Calcium signaling and nucleotide metabolism
- High Altitude and Hypoxia
- Hippo pathway signaling and YAP/TAZ
- Mosquito-borne diseases and control
- Muscle Physiology and Disorders
- Plant-derived Lignans Synthesis and Bioactivity
Centre National de la Recherche Scientifique
2001-2024
Epigénétique et Destin Cellulaire
2009-2024
Université Paris Cité
2009-2024
Inserm
2002-2023
Sorbonne Paris Cité
2011-2019
Délégation Paris 7
2012-2013
Université de Bourgogne
2011
Institut Cochin
2011
Délégation Paris 5
2011
The Honourable Society of Lincoln's Inn
2007-2009
Abstract Upregulation of the matrix metalloproteinase (MMP)–9 plays a central role in tumor progression and metastasis by stimulating cell migration, invasion, angiogenesis. To gain insights into MMP-9 expression, we investigated its epigenetic control reversible model cancer that is initiated infection with intracellular Theileria parasites. Gene induction parasite was associated trimethylation histone H3K4 (H3K4me3) at promoter. Notably, found methyltransferase SMYD3 only upregulated upon...
The intracellular parasite Theileria is the only eukaryote known to transform its mammalian host cells. We investigated mechanisms involved in parasite-induced transformation phenotypes. Tumour progression a multistep process, yet 'oncogene addiction' implies that cancer cell growth and survival can be impaired by inactivating single gene, offering rationale for targeted molecular therapies. Furthermore, feedback loops often act as key regulatory hubs tumorigenesis. searched microRNAs...
Intracellular pathogens develop elaborate mechanisms to survive within the hostile environments of host cells. Theileria parasites infect bovine leukocytes and cause devastating diseases in cattle developing countries. spp. have evolved sophisticated strategies hijack leukocytes, inducing proliferative invasive phenotypes characteristic cell transformation. secrete proteins into recruit induce oncogenic signaling for parasite survival. It is unknown how evade defense mechanisms, such as...
Abstract hSNF5/INI1, which encodes a component of the ATP-dependent chromatin remodeling hSWI-SNF complex, is tumor suppressor gene mutated in malignant rhabdoid tumors. We have developed tetracycline-based hSNF5/INI1-inducible system hSNF5/INI1-deficient cell line and studied time course variation 22,000 genes/expressed sequence tags upon hSNF5/INI1 induction. A total 482 responsive genes were identified further clustered into 9 groups coregulated genes. Among with early strong inductions,...
Plants are an invaluable source of potential new anti-cancer drugs. Here, we investigated the cytotoxic activity acetonic extract Buxus sempervirens on five breast cancer cell lines, MCF7, MCF10CA1a and T47D, three aggressive triple positive BT-20 MDA-MB-435, which negative lines. As a control, MCF10A, spontaneously immortalized but non-tumoral line has been used. The showed towards all studied lines with IC50 ranging from 7.74 µg/ml to 12.5 µg/ml. Most importantly, plant was less toxic...
Abstract Metabolic reprogramming is an important feature of host–pathogen interactions and a hallmark tumorigenesis. The intracellular apicomplexa parasite Theileria induces Warburg-like effect in host leukocytes by hijacking signaling machineries, epigenetic regulators transcriptional programs to create transformed cell state. molecular mechanisms underlying transformation are unclear. Here we show that parasite-encoded prolyl-isomerase, TaPin1, stabilizes pyruvate kinase isoform M2 (PKM2)...
Mechanical cues from the cellular microenvironment are converted into biochemical signals controlling diverse cell behaviours, including growth and differentiation. But it is still unclear how mechanotransduction ultimately affects nuclear readouts, genome function transcriptional programs. Key signaling pathways transcription factors can be activated, relocalize to nucleus, upon mechanosensing. Here, we tested hypothesis that epigenetic regulators, such as methyltransferase enzymes, might...
Abstract The coordinated expression of myogenic regulatory factors, including MyoD and myogenin, orchestrates the steps skeletal muscle development, from myoblast proliferation cell-cycle exit, to fusion myotubes maturation. Yet, it remains unclear how key transcription factors epigenetic enzymes cooperate guide differentiation. Proteins SMYD (SET MYND domain-containing) methyltransferase family participate in cardiac myogenesis during development zebrafish, Drosophila mice. Here, we show...
OPINION article Front. Cell Dev. Biol., 17 March 2020Sec. Growth and Division Volume 8 - 2020 | https://doi.org/10.3389/fcell.2020.00134
Abstract Theileria parasites are responsible for devastating cattle diseases, causing major economic losses across Africa and Asia. spp. stand apart from other apicomplexa by their ability to transform host leukocytes into immortalized, hyperproliferating, invasive cells that rapidly kill infected animals. The emergence of resistance the theilericidal drug Buparvaquone raises need new anti- drugs. We developed a microscopy-based screen reposition drugs open-access Medicines Malaria Venture...
Abstract Abscission is the final stage of cytokinesis, which cleaves intercellular bridge (ICB) connecting two daughter cells. requires tight control recruitment and polymerization Endosomal Protein Complex Required for Transport-III (ESCRT-III) components. We explore role post-translational modifications in regulating ESCRT dynamics. discover that SMYD2 methylates lysine 6 residue human CHMP2B, a key ESCRT-III component, at ICB, impacting dynamic relocation CHMP2B to sites abscission....
ABSTRACT The coordinated expression of myogenic regulatory factors, including MyoD and myogenin, orchestrates the steps skeletal muscle development, from myoblast proliferation cell-cycle exit, to fusion myotubes maturation. Yet, it remains unclear how key transcription factors epigenetic enzymes cooperate guide differentiation. Proteins SMYD (SET MYND domain-containing) methyltransferase family participate in cardiac myogenesis during development zebrafish, Drosophila mice. Here, we show...
Mechanical cues from the cellular microenvironment are converted into biochemical signals controlling diverse cell behaviours, including growth and differentiation. But it is still unclear how mechanotransduction ultimately affects nuclear readouts, genome function transcriptional programs. Key signaling pathways transcription factors can be activated, relocalize to nucleus, upon mechanosensing. Here, we tested hypothesis that epigenetic regulators, such as methyltransferase enzymes, might...
<div>Abstract<p><i>hSNF5/INI1</i>, which encodes a component of the ATP-dependent chromatin remodeling hSWI-SNF complex, is tumor suppressor gene mutated in malignant rhabdoid tumors. We have developed tetracycline-based hSNF5/INI1-inducible system <i>hSNF5/INI1</i>-deficient cell line and studied time course variation 22,000 genes/expressed sequence tags upon hSNF5/INI1 induction. A total 482 responsive genes were identified further clustered into 9...
<div>Abstract<p><i>hSNF5/INI1</i>, which encodes a component of the ATP-dependent chromatin remodeling hSWI-SNF complex, is tumor suppressor gene mutated in malignant rhabdoid tumors. We have developed tetracycline-based hSNF5/INI1-inducible system <i>hSNF5/INI1</i>-deficient cell line and studied time course variation 22,000 genes/expressed sequence tags upon hSNF5/INI1 induction. A total 482 responsive genes were identified further clustered into 9...
Supplementary Figure 1 from The Tumor Suppressor hSNF5/INI1 Modulates Cell Growth and Actin Cytoskeleton Organization