A5088742042- Systemic Lupus Erythematosus Research
- Renal Diseases and Glomerulopathies
- Renal and related cancers
- Genetic and Kidney Cyst Diseases
- Vasculitis and related conditions
- Vitamin D Research Studies
- Immune Cell Function and Interaction
- Autoimmune and Inflammatory Disorders Research
- Neurogenetic and Muscular Disorders Research
- Pediatric Urology and Nephrology Studies
- Muscle and Compartmental Disorders
- Cell Adhesion Molecules Research
- Medical Imaging and Pathology Studies
- Alkaline Phosphatase Research Studies
- T-cell and B-cell Immunology
- Connective tissue disorders research
- Mechanisms of cancer metastasis
- Chronic Kidney Disease and Diabetes
- Inflammatory Myopathies and Dermatomyositis
- Parathyroid Disorders and Treatments
- Cholesterol and Lipid Metabolism
- Cytokine Signaling Pathways and Interactions
- Adrenal Hormones and Disorders
- Sports injuries and prevention
- Inflammasome and immune disorders
Second Hospital of Hebei Medical University
2011-2024
Hebei Medical University
2008-2024
Background Nephronophthisis-related ciliopathies (NPHP-RC) account for the majority of cases monogenetically caused end-stage renal disease (ESRD) in children. Exploring correlation between phenotype and genotype NPHP-RC is helpful early diagnosis management. We investigated spectra a Chinese multicentre cohort. Methods Crosss-ectional longitudinal data 60 patients from 57 families with pathogenic gene mutations distributed 22 regions China were collected into unified, anonymous database....
Abstract Objective The aim of this study is to identify whether low lupus disease activity status (LLDAS) and clinical remission (CR) belimumab plus standard care (SoC) therapy are achievable goals in childhood-onset SLE (cSLE). Methods This multicentre, one arm pre-post intervention was conducted at 15 centres China. primary end point describe the proportion patients who achieved LLDAS CR after 3, 6 12 months treatment with SoC therapy. A multiple regression model used impute missing data....
In the present study, effect and mechanism of periostin on renal proliferation extracellular matrix accumulation lupus mice were investigated. MRL /lpr mice, known as revealed to show enhanced periostin, proliferating cell nuclear antigen (PCNA), in kidney accompanied by increased serum platelet-derived growth factor (PDGF). Again, cultured mouse mesangial cells (MMCs) treated with PDGF, then PCNA secreted fibronectin detected. The results showed that intracellular respectively 2.691 2.308...
Background T helper 17 (Th17) cells and regulatory (Treg) are known to play a crucial role in the pathogenesis of systemic lupus erythematosus (SLE). Improving balance between Treg Th17 can be promising new therapeutic target SLE patients. Vitamin D has significant impact on immune inflammatory process involved this process. The purpose study is investigate relationship Th17, Treg, cytokines, serum 25 hydroxyvitamin [25(OH)D] patients with initial-onset childhood SLE. Methods A total 82...
Vitamin D deficiency is common in patients with systemic lupus erythematosus (SLE) and may affect their disease activity severity.This study aims to assess the vitamin status initial-onset SLE during childhood its association clinical laboratory markers of activity.This a retrospective that includes 168 109 healthy children as controls. Clinical data were recorded. The area under curve (AUC) method was used evaluate efficacy double-stranded deoxyribonucleic acid (dsDNA), lower 25(OH)D...
Purpuric nephritis is the most common secondary glomerular disease in childhood. Its prevalence children has been steadily rising recent years.To explore characteristics and pathogenesis of changes peripheral blood lymphocyte subsets immune function with Henoch-Schonlein purpura nephritis.The study included 104 purpura, divided into (HSPN) group (68 cases) non-nephritis (NHSPN) (36 cases), 15 normal children. The rate-scatter turbidimetric method was utilized to determine immunoglobulins...
Objective: To identify the gene mutation of Stormorken syndrome and review published Stromal Interaction Molecule 1 (STIM1) phenotype. Methods: We described clinical molecular aspects a Chinese female with by laboratory tests, muscle biopsies, genetic analysis. used this information to summarize all sites reported in literature. also reviewed features cases gain function mutations STIM1. Results: A 12-year-old presented skin purpura lower limbs stroke-like episodes. Muscle biopsy microscopic...
Abstract Background This study investigates the clinical characteristics and outcomes of pediatric patients with rheumatic diseases infected COVID-19 in China. Methods We conducted a retrospective analysis who contracted COVID-19. Data were collected via comprehensive questionnaire 14-day follow-up. Multivariable logistic regression was used to assess severe outcomes, network analyses evaluated symptom correlations. Results A total 1070 cases collected. Fever (88.05%) cough (62.75%) most...
Background: To observe the changes of autophagy-related protein levels in peripheral blood lymphocytes before and after sirolimus treatment children with systemic lupus erythematosus (SLE). Methods: Children SLE were randomly divided into two groups, 28 traditional group group. Fifteen healthy who same period collected as normal control Clinical laboratory indexes, percentage routine lymphocytes, complement C3, C4, serum Anti-dsDNA SLEDAI detected. Results: At 3 6 months treatment, compared...
Objective To observe the morphologic changes and expression of suppressor cytokine signaling-1/3(SOCS-1/3) in renal tubular epithelial cells induced by high glucose(HG) to investigate their significance. Methods The cell line(HKCs) cultured vitro were divided into blank control group,HG group,and Janus kinase 2 inhibitor AG490 group.HKC group was for 8 hours 5.5 mmol/L glucose,and other two groups 300.0 glucose or glucose+10 μmol/L 2,4,6,12,24,48 hours(n=6).The morphology ultrastructure...
To improve the understanding of clinical phenotypes and genetic characteristics nephronophthisis (NPHP) related syndromes in children.A retrospective analysis was performed on medical data eight children with NPHP who were diagnosed treated Department Pediatrics Second Hospital Hebei Medical University, from January 2018 to November 2022. The testing results analyzed.Among these children, there five boys three girls, an age onset ranging 15 months 12 years. All 8 exhibited different degrees...
1例主诉为身高增长缓慢4年余，发现肾功能异常1 d患儿，有慢性肾功能不全，视网膜色素变性，指骨锥形骨骺，股骨近端轻度的放射学异常，身材矮小及胸廓异常改变等临床特征，结合高通量二代测序技术，明确诊断为Mainzer-Saldino综合征，由IFT140基因复合杂合变异引起，为2个未报道的新发变异。.
Abstract Background: This study aimed to investigate the clinical and pathological characteristics profile of temporal changes in glomerular diseases 2403 paediatric renal biopsies from 1999 2019. Methods: Renal performed on children aged ≤18 years between 2019 were analysed at our centre. We histological characteristics, distribution with various presentations, pattern kidney disease during period. Results: The most common primary was IgA nephropathy (IgAN) (24.3%), followed by minimal...
Abstract Background: This study aimed to investigate the clinical and pathological characteristics changes in glomerular diseases 2403 pediatric renal biopsies from 1999 2019. Methods: Renal performed on children aged ≤18 years between 2019 were analysed at our center. We histological characteristics, distribution of with various presentations, disease patterns during period. Results: The most common primary was IgA nephropathy (IgAN) (24.3%), followed by minimal change (MCD) (15.3%)...