This study is the first in Saudi Arabia to explore knowledge, attitudes, and barriers of community pharmacists managing autism spectrum disorder (ASD). ASD a neurodevelopmental condition requiring multidisciplinary care, with playing pivotal role medication management patient support. Despite their accessibility, limited data exist on pharmacists’ preparedness for care Arabia. A cross-sectional was conducted among 254 Aseer region using validated questionnaire. The survey assessed knowledge...

The purpose of study was to evaluate the association between prognostic nutritional index (PNI) and all-cause mortality critically ill patients with stroke.Clinical data derived from Multiparameter Intelligent Monitoring in Intensive Care were analyzed. primary endpoint 30-day mortality; secondary endpoints 90-day one-year cause mortality. potential roles PNI analyzed by Cox proportional hazard models. independent cases smooth curve fitting.Concerning mortality, HR (95% CI) for a high...

Drug repurposing, rebranding an existing drug for a new therapeutic indication, is deemed beneficial approach quick and cost-effective discovery process by skipping preclinical, Phase 1 trials pharmacokinetic studies. Several psychotropic drugs including selective serotonin reuptake inhibitors (SSRIs) tricyclic antide-pressants (TCAs) were studied their potential application in different diseases es-pecially cancer therapy. Fluoxetine (FLX) one of the most prescribed agents from SSRIs class...

Public awareness regarding COVID-19 plays an important role in controlling the virus' spread and treating infected people. A high level of among public will help to implement preventive measures, particularly most populated regions, such as Makkah, Saudi Arabia. is infectious disease Arabian government has taken serious precautions implemented several measures. In addition, The Ministry Health (MOH) launched many campaigns provided vaccines for free.To assess Public's health knowledge toward...

Oats are represented an important source for nutrition, and it have attracted a lot of attention in recent years. In this study we produced oatmeal cookies oats was added to formula wheat by 50% 75%. Also, cinnamon treatments 3 4 5% increase nutrition value cookies, improvement sensory evaluation antioxidant properties. All the were storage at room temperature. The purposes activity cinnamon. Also determined chemical composition include (moisture content, protein, ash, total lipids, crude...

Dermoid cysts are benign tumors originating from germ cells, which can form in various locations, including the nasal area rare cases. They of unknown exact etiology, but it is suggested that due to abnormal tissue migration during early embryonic development. Nasal dermoid albeit rare, present forms such as sinuses, fistulas, or intracranially extending tracts. be asymptomatic and incidentally discovered with a visible external mass sinus either painful, infected cosmetically concerning. If...

Nuclear receptors (NRs) constitute a superfamily of ligand-activated transcription factors with paramount role in ubiquitous physiological functions such as metabolism, growth, and reproduction. Owing to their druggability, NRs are deemed attractive valid targets for medicinal chemists. Pentacyclic triterpenes (PTs) represent one the most important phytochemical classes present higher plants, where oleanolic acid (OA) is studied PTs representative owing its multitude biological activities...

Lung squamous cell carcinoma (LUSC) is one of the most common malignancies. There growing evidence that glycolysis-related genes play a critical role in tumor development, maintenance, and therapeutic response by altering metabolism thereby influencing immune microenvironment. However, overall impact on prognostic significance, microenvironment characteristics, treatment outcome patients with LUSC has not been fully elucidated. We used The Cancer Genome Atlas (TCGA) dataset to screen effects...

The genetic structure of four populations Androctonus crassicauda (Olivier, 1807) from different ecogeographical regions Saudi Arabia was studied. To detect differences among populations, the sequences cytochrome oxidase subunit I gene 21 individuals A. Arabia, and 11 Iran were utilised. nucleotide haplotype diversity constructed. results revealed a high level within all populations. A total eighteen haplotypes identified, 17 which unique. Molecular variance analysis (AMOVA) indicated...

Although incidences of gastric cancer have decreased in recent years, the disease remains a significant danger to human health. Lack early symptoms often leads delayed diagnosis cancer, so that many patients miss opportunity for surgery. Treatment advanced is limited. Immunotherapy, targeted therapy, and mRNA vaccine all emerged as potentially viable treatments cancer. However, our understanding immune microenvironment far from sufficient; now time explore this microenvironment.In study,...

Antioxidants are used to prevent oxidative changes and flavor development in oils fats. The aim of this study is evaluate the antioxidant effect adding thyme powder added on sunflower oil during frying at different temperature intervals (250 ± 1 °C). Thyme powders were ratio 0.5%, 1% 1.5%, period estimated for 2 h 250 °C. samples collected 0.5, 1, 1.5, potatoes fried each time. activity was 93.05 %, using DPPH root scanning methods. values acid, peroxide and, saponification, ​​and fatty acid...

This study conducted to evaluate the effect of additional dried moringa leaves on bread and their effects chemical biological rats fed it. Wheat flour with powder (DMLB) is used at different levels (6 9%) produce bread. We performed a sensory evaluation wheat substituted leaves, properties (approximate composition antioxidants), microbiology (total bacteria, spore-forming fungi, yeast) analysis (Triglycerides, total cholesterol, HDL LDL, ALT, AST, urea, creatinine). Therefore, histopathology...

The diagnostic and prognostic utility of circulating cell-free DNA (cfDNA) in breast cancer (BC) patients was recently reported. Here, we investigated the use cfDNA to examine microsatellite instability (MSI) loss heterozygosity (LOH) for early BC diagnosis. genomic from 41 female 40 healthy controls were quantified using NanoDrop spectrophotometry real-time PCR. stability assessed a high-resolution AmpFlSTR MiniFiler human identification kit. Significant increases plasma concentrations...

Abstract Malignancies are one of the world’s most serious health problems. Pancreatic and lung cancers two lethal types cancer, with 5-year survival rates ranging from 10 to 20%. Despite decades investigation, molecular processes selectivity Prunus armenica Bee venom as anticancer drugs still largely un-understood. The goal our study is determine expression levels ofp53 Bcl-2 mRNAs obtained human pancreatic (PANC-1) (A549) cancer cells treated , or their combinations by using MTT real time...

Lactobacillus plantarum Bu-Eg5 and rhamnosus Bu-Eg6 showed a potential probiotic role in vivo vitro preliminary unpublished work. This study demonstrated that mediated modifications of the physicochemical properties fermented skimmed cow's milk. Skim milk was inoculated with 1% (w/v) (T1), (T2) 1:1 (T3). After that, fresh control (C), T1, T2, T3 were freeze-dried (Zirbus Technology model: VaCo 5-D, S/N: COM98754, Germany). The resulting milks powders evaluated for their solubility index,...

Head and neck squamous cell carcinoma (HNSCC) is a type of tumour with relatively poor prognosis. In recent years, immune checkpoint inhibitors, such as CTLA-4 PD-1/PDL-1 have improved the treatment status advanced tumours. However, emergence drug resistance has brought difficulties to clinical treatment, new research imminent. The hypoxia-adenosine pathway, in which CD73 encoded by NT5E gene key enzyme for adenosine production, been identified an great potential. Therefore, may play...

Pancreatic cancer (PC) is considered one of the most challenging and formidable malig-nancies to treat because it usually diagnosed at terminal stage, thus characterized with a poor prognosis 5% patients living over 5 years. The late diagnosis leads lower suc-cess rate resectability, hence chemotherapy or chemoradiotherapy are only hopes for PC patients. However, available drug combinations treatment did not provide satisfactory clinical outcomes. There pressing urgent need discover new...

Choanal atresia (CA) is a rare occlusion of the posterior choanae. Unilateral cases have been reported more than bilaterally, and it's often right-sided in those patients. According to literature, mixed bony-membranous most common type. There high incidence craniofacial visceral anomalies associated with congenital choanal atresia. Therefore, investigation for an important step before surgery. We report 2 incidental finding unilateral 21- 17-year-old nasal discharge being only complaint...

Drug repurposing, rebranding an existing drug for a new therapeutic indication, is deemed beneficial approach quick and cost-effective discovery process by skipping preclinical, Phase 1 trials pharmacokinetic studies. Several psychotropic drugs, including selective serotonin reuptake inhibitors (SSRIs) tricyclic antidepressants (TCAs), were studied their potential application in different diseases, especially cancer therapy. Fluoxetine (FLX) one of the most prescribed agents from SSRIs class...

Background: Gastric cancer (GC) is considered the fifth most prevalent type of and third leading cause deaths worldwide. This in-depth investigation was performed to generate fresh concepts for clinical classification, diagnosis, prognostic evaluation GC. Methods: The data were retrieved from Gene Expression Omnibus (GEO) Cancer Genome Atlas (TCGA) databases. Unsupervised cluster analysis used divide up GC patients using pyroptosis-related differentially expressed genes (DEGs), which...

Pancreatic cancer is one of the most harmful and lethal cancers in United States. It fourth leading cause death, with only 8.5% patients surviving more than 5 years. The receptor for advanced glycation end products (RAGE) has been associated progression development pancreatic cancer. RAGE ligands, Advanced Glycation End (AGE), proteins S100 family, chromatin binding protein high-mobility group box 1 (HMGB1), have all shown to be present high levels tumors. In addition, HMGB1 secreted by...