A5055109483- Cancer-related molecular mechanisms research
- Geochemistry and Geologic Mapping
- Cancer, Hypoxia, and Metabolism
- Geochemistry and Geochronology of Asian Mineral Deposits
- Geological and Geochemical Analysis
- Nitric Oxide and Endothelin Effects
- Drug Transport and Resistance Mechanisms
- Medicinal Plant Pharmacodynamics Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Analytical Chemistry and Chromatography
- Esophageal Cancer Research and Treatment
- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Ubiquitin and proteasome pathways
- Chemical Thermodynamics and Molecular Structure
- Angiogenesis and VEGF in Cancer
- Circular RNAs in diseases
- Cancer-related Molecular Pathways
- Eicosanoids and Hypertension Pharmacology
- Genetic Associations and Epidemiology
- RNA modifications and cancer
- Multiple Myeloma Research and Treatments
- Histone Deacetylase Inhibitors Research
- Infectious Encephalopathies and Encephalitis
- Caveolin-1 and cellular processes
Guangzhou University of Chinese Medicine
2022
Kangda College of Nanjing Medical University
2021
The First People’s Hospital of Lianyungang
2021
Nanjing Medical University
2021
Cangzhou Central Hospital
2020
Tianjin First Center Hospital
2020
Tianjin Medical University
2020
University of Oxford
2009-2019
Second Hospital of Shanxi Medical University
2019
Shanxi Medical University
2019
The availability of bromodomain and extra-terminal inhibitors (BETi) has enabled translational epigenetic studies in cancer. BET proteins regulate transcription by selectively recognizing acetylated lysine residues on chromatin. BETi compete with this process leading to both downregulation upregulation gene expression. Hypoxia enables progression triple negative breast cancer (TNBC), the most aggressive form cancer, partly driving metabolic adaptation, angiogenesis metastasis through...
Delta-like ligand 4 (Dll4) is a Notch that upregulated by hypoxia and vascular endothelial growth factor-A (VEGF-A) reported to have role in tumor angiogenesis. Evidence from xenograft studies suggests inhibiting Dll4–Notch signalling may overcome resistance anti-VEGF therapy. The aim of this study was characterise the expression Dll4 colon cancer assess whether it associated with markers prognosis. In all, 177 cancers were represented tissue microarrays. Immunohistochemistry performed using...
Cholangiocarcinoma (CCA) is the second most common primary malignant hepatobiliary cancer worldwide. The circular RNA (circRNA) Cdr1as has been found to play critical roles in various cancers. However, relationship between circRNA and CCA still ambiguous. aim of this study was explore expression level further investigate clinicopathological prognostic value Cdr1as.We investigated 54 paired tumor adjacent normal tissues patients by using quantitative Real-time PCR, evaluated relevance...
Tumour cells can use strategies that make them resistant to nutrient deprivation outcompete their neighbours. A key integrator of the cell's responses starvation and other stresses is amino-acid-dependent mechanistic target rapamycin complex 1 (mTORC1). Activation mTORC1 on late endosomes lysosomes facilitated by amino-acid transporters within solute-linked carrier 36 (SLC36) SLC38 families. Here, we analyse functions SLC36 family member, SLC36A4, otherwise known as proton-assisted...
Preeclampsia is one of the leading causes maternal and perinatal deaths. This study mainly explored mechanism long non-coding RNA (lncRNA) CCAT1 expression in placenta preeclampsia patients its effect on progression preeclampsia.We used quantitative reverse transcription PCR (qRT‑PCR) to detect lncRNA 40 normal pregnancy samples. relationship with clinicopathological parameters was statistically analyzed. The specific small interfering (si-CCAT1) plasmid (pcDNA-CCAT1) targeting were...
Wilms' tumor (WT) is the most common malignant renal in children. MicroRNAs (MiRNAs) function progression of various cancers. Recent reports have reported that miR-140-5p and miR-92a-3p are dysregulated WT tissues, but potential mechanisms two miRNAs modulating still poorly understood.Quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) was conducted to detect expression levels miR-140-5p, miR-92a-3p, fibroblast growth factor receptor substrate 2 (FRS2) tissues cells, as well matched...
Objective We attempted to clarify the regulatory mechanism of UCA1/miR-331-3p/IL6R on cell progression in multiple myeloma (MM). Patients and methods The expression UCA1, miR-331-3p, IL6R tumor tissues cells was measured by qRT-PCR. Cell Counting Kit-8 (CCK-8) conducted detect proliferation, flow cytometry assay applied examine apoptosis. Protein L6R, p-JAK2, p-STAT3, c-Myc, CyclinD1, Bcl-2, Bax detected Western blot assay. interaction among determined Luciferase reporter system. Murine...
Oesophageal squamous cell carcinoma (SCC) causes the highest number of cancer deaths in some regions Northern China. Previously, we narrowed down a critical region at 9q33-34, identified to be associated with tumour-suppressive function deleted oesophageal 1 (DEC1) SCC. We generated DEC1 antibody and constructed tissue microarrays (TMAs) utilising specimens from Henan, high-risk for SCC, investigate importance expression this cancer. Tissue microarray immunohistochemical staining reveals...
OBJECTIVE: To explore the relationship between endothelial nitric oxide synthase (eNOS) activity, insulin resistance and macrovascular disease in patients with acute myocardial infarction (AMI). METHODS: AMI were grouped according to presence (group A, n = 49) or absence B, 48) of disease. A healthy control group was also recruited C, 43). eNOS activity (NO), endothelin-1 (ET-1), fasting plasma glucose levels compared across groups. The homeostasis model assessment (HOMA—IR) calculated each...
Structural and metabolic abnormalities in the hippocampus have been associated with pathophysiological mechanism of central nervous system involvement primary Sjögren syndrome (pSS). Nevertheless, how hippocampal function is altered pSS remains unknown. The purpose our study to investigate alterations functional connectivity (FC) by using resting-state magnetic resonance imaging (rs-fMRI). Thirty-eight patients 38 age- education level-matched healthy controls (HCs) underwent examination....
OBJECTIVE The aim of this study was to explore the role microRNA-411 in diabetic retinopathy (DR) and further understand its mechanism action. MATERIALS AND METHODS A rat model diabetes (20 DM group) a normal control group established. changes blood glucose body weight were compared between two groups. At same time, expression Roundabout 4 (ROBO4) groups rats detected. biological prediction potential binding sites ROBO4 verified by Dual-Luciferase reporter gene assay, regulatory relationship...
PTENP1, a long noncoding RNA, has previously been reported to be involved in tumorigenesis and cancer progression. The relationship between PTENP1 susceptibility tumors is reported, while, an association of with the risk oral squamous cell carcinoma (OSCC) Chinese population lacked. This research designed investigate OSCC.In this research, TaqMan technology was used test genotype 342 OSCC patients 711 healthy controls, so as analyze polymorphisms (rs7853346 rs865005 rs10971638) carcinoma.The...
Tumour necrosis factor (TNF) is a multi-functional cytokine with profound and diverse effects on physiology pathology. Identifying the molecular determinants underlying functions pathogenic of TNF key to understanding its mechanisms action identifying new therapeutic opportunities based this important molecule. Previously, we showed that some evolutionarily conserved peptides derived from could induce cell death (e.g. apoptosis and/or necrosis), feature immune defence shared by many...
The aim of this study was to explore the influences sevoflurane inhalation therapy on circulation function and pulmonary fibrosis in rats with arterial hypertension (PAH) nuclear factor-κB (NF-κB) signaling pathway.A total 30 adult male Sprague-Dawley were randomly divided into three groups, including control group (CTL group, n=10), PAH (n=10), + (n=10) using a random number table. Subsequently, artery right ventricular systolic pressure (RVSP) hypertrophy index (RVHI) measured. Rats...
Pelizaeus-Merzbacher disease (PMD) is a rare X-linked recessive disorder characterized by nystagmus, impaired motor development, ataxia, and progressive spasticity.Genetically defective or altered levels of proteolipid protein (PLP1) gapjunction alpha 12 gene have been found to be common cause.Here we report on two large Han Chinese families affected with this disease.The probands both had produced sons featuring cerebral palsy that never correctly diagnosed.Y. Lv et al. 2036PMD was...