A5033646723- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Epigenetics and DNA Methylation
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- RNA modifications and cancer
- Pancreatic function and diabetes
- RNA Interference and Gene Delivery
- Aortic Disease and Treatment Approaches
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- 3D Printing in Biomedical Research
- Metabolism and Genetic Disorders
- Immune Response and Inflammation
- Mitochondrial Function and Pathology
- Extracellular vesicles in disease
- Tissue Engineering and Regenerative Medicine
- Genetics and Neurodevelopmental Disorders
- Adipose Tissue and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Aortic aneurysm repair treatments
- Connective tissue disorders research
- Circular RNAs in diseases
- Neurogenesis and neuroplasticity mechanisms
University of Lausanne
2022-2024
Universidad Autónoma de Madrid
2017-2021
Centro de Biología Molecular Severo Ochoa
2017-2021
Consejo Superior de Investigaciones Científicas
2020-2021
Research Institute Hospital 12 de Octubre
2016-2021
Hospital Universitario 12 De Octubre
2018
The effect of immunometabolism on age-associated diseases remains uncertain. In this work, we show that T cells with dysfunctional mitochondria owing to mitochondrial transcription factor A (TFAM) deficiency act as accelerators senescence. mice, these instigate multiple aging-related features, including metabolic, cognitive, physical, and cardiovascular alterations, which together result in premature death. cell metabolic failure induces the accumulation circulating cytokines, resembles...
Marfan syndrome (MFS) is an autosomal dominant disorder of the connective tissue caused by mutations in
Different microRNAs (miRNAs), including miR-29 family, may play a role in the development of heart failure (HF), but underlying molecular mechanisms HF pathogenesis remain unclear. We aimed at characterizing mice deficient order to address functional relevance this family miRNAs cardiovascular system and its contribution disease. In work, we show that miR-29a/b1 develop vascular remodeling systemic hypertension, as well with preserved ejection fraction (HFpEF) characterized by myocardial...
Aging is the major risk factor for most human diseases and represents a socio-economical challenge modern societies. Despite its importance, process of aging remains poorly understood. Epigenetic dysregulation has been proposed as key driver process. Modifications in transcriptional networks chromatin structure might be central to age-related functional decline. A prevalent feature described during overall reduction heterochromatin, specifically marked by loss repressive histone...
Unlike aged somatic cells, which exhibit a decline in molecular fidelity and eventually reach state of replicative senescence, pluripotent stem cells can indefinitely replenish themselves while retaining full homeostatic capacity. The conferment beneficial-pluripotency related traits via
Summary In vivo reprogramming through the forced expression of Oct4, Sox2, Klf4, and c-Myc (OSKM) has demonstrated great potential for reversing age-associated phenotypes, as combination these transcription factors actively promote cell regeneration rejuvenation in various tissues organs. However, continuous OSKM raised safety concerns due to loss identity, decrease body weight, premature death. Although cyclic short-term or targeted can mitigate some detrimental effects mice, systemic wild...
SUMMARY The induction of cellular reprogramming by forced expression the transcription factors OCT4, SOX2, KLF4, and C-MYC (OSKM) has been shown to allow dedifferentiation somatic cells ameliorate age-associated phenotypes in multiple tissues organs. Yet date, benefits vivo are limited occurrence detrimental side-effects. Here, using complementary genetic approaches, we demonstrated that continuous leads hepatic intestinal dysfunction resulting decreased body weight premature death. By...
Abstract Unlike aged somatic cells, which exhibit a decline in molecular fidelity and eventually reach state of replicative senescence, pluripotent stem cells can indefinitely replenish themselves while retaining full homeostatic capacity. The conferment beneficial-pluripotency related traits via vivo partial cellular reprogramming (IVPR) significantly extends lifespan restores aging phenotypes mouse models. Although the phases are well characterized, details rejuvenation processes poorly...
Abstract Age-associated neurodegenerative disorders represent significant challenges due to progressive neuronal decline and limited treatments. In aged mice, partial reprogramming, characterized by pulsed expression of reprogramming factors, has shown promise in improving function various tissues, but its impact on the aging brain remains poorly understood. Here we investigated vivo mature neurons dentate gyrus young mice. Using two different approaches – a neuron-specific transgenic...
<title>Abstract</title> Aging is the major risk factor for most human diseases and represents a socio-economical challenge modern societies. Despite its importance, process of aging remains poorly understood. Epigenetic dysregulation has been proposed as key driver process. Alterations in transcriptional networks chromatin structure might be central to age-related functional decline. A prevalent feature described during overall reduction heterochromatin, specifically marked by loss...